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PF4 encodes a member of the CXC chemokine family. Zusätzlich bieten wir Ihnen Platelet Factor 4 Antikörper (168) und Platelet Factor 4 Kits (107) und viele weitere Produktgruppen zu diesem Protein an.
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PF4 was produced by Ly6G+CD11b (zeige ITGAM Proteine)+ immature myeloid cells in the early stage premetastatic lungs, and decreased during metastatic progression.
The CXCL4 monomer acts as the minimal active unit for interacting with CXCR3 (zeige CXCR3 Proteine) N-Terminal Sulfated (zeige SULF1 Proteine) Peptide, and sulfation of N-terminal tyrosine residues on the receptor is important for binding.
These findings support PF4 as a cancer-enhancing endocrine signal that controls discrete aspects of bone marrow hematopoiesis and tumor microenvironment.
data support that increased levels of circulating CXCL4 may contribute to immune dysregulation through the modulation of dendritic cell differentiation
Endometrial CXCL4 mRNA concentrations were significantly increased during menstruation. In women with heavy menstrual bleeding, CXCL4 was reduced in endothelial cells during the menstrual phase compared with women with normal menstrual bleeding. These data implicate CXCL4 in endometrial repair after menses.
Two haplotype blocks, one upstream to the coding region of UGT2A1 (rs146712414, P = 9.1 x 10(-5); odds ratio [OR], 1.34; 95% confidence interval [CI], 1.16-1.56) and one downstream of the genes PF4/PPBP/CXCL5 (rs1595009, P = 1.3 x 10(-4); OR, 1.32; 95% CI, 1.15-1.52), were associated with AgP.
These data demonstrate that the CXCR2 (zeige CXCR2 Proteine) network and CXCL4 play a role in the maintenance of normal HSC (zeige FUT1 Proteine)/HPC cell fates, including survival and self-renewal.
The major aim of this review article was to evaluate the role of CXCL4 in hematological malignancies, promotion of HSC (zeige FUT1 Proteine) quiescence as well as BM niche cells.
binding of PF4 to perlecan (zeige HSPG2 Proteine) was found to inhibit both FGF2 (zeige FGF2 Proteine) signaling and platelet activation
CXCL4 plays an important role in pancreatic inflammation
These results indicate that CXCL4 is a novel Ni-binding protein that augments Ni allergy at the elicitation and sensitization phases. This is the first study to demonstrate that the Ni-binding protein augments Ni allergy in vivo.
Platelet-derived CXCL7 (zeige PPBP Proteine) and CXCL4 contribute to the pathogenesis of acute lung injury.
Platelet secretion of CXCL4 is Rac1-dependent and regulates neutrophil infiltration and tissue damage in septic lung damage
PF4 has a complex intramedullary life cycle with important implications in megakaryopoiesis and hematopoietic stem cell replication not seen with other tested alpha granule proteins.
Heparin enhances antigen uptake and activation of the initial steps in the cellular immune response to PF4-containing complexes.
Data indicate that platelet factor 4 (PF4) is involved directly in liver innate immune response against ischaemia-reperfusion injury (IRI) by regulating Th17 cell differentiation.
CXCL4 regulates hematopoietic stem cell cell cycle activity.
This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function.
platelet factor 4 (chemokine (C-X-C motif) ligand 4)
, C-X-C motif chemokine 4
, chemokine (C-X-C motif) ligand 4