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May determine the distinct specification program of class A neurons in the dorsal part of the spinal cord and suppress specification of class B neurons.. Zusätzlich bieten wir Ihnen Oligodendrocyte Transcription Factor 3 Antikörper (48) und viele weitere Produktgruppen zu diesem Protein an.
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olig4 expression is expanded in prdm1a (zeige PRDM1 Proteine) mutants and olig4 knockdown can rescue the reduced or abrogated neural crest and Rohon-Beard neuron phenotype in prdm1a (zeige PRDM1 Proteine) mutants
olig3 has an essential proneural activity in the dorsal spinal cord and cooperates with the Delta/Notch (zeige NOTCH1 Proteine) regulatory loop to establish the boundary between the neural crest and the lateral neural plate.
SNP within the OLIG3/TNFAIP3 (zeige TNFAIP3 Proteine) locus (rs6920220) was associated with being less likely to maintain MTX (zeige MTX1 Proteine) monotherapy
Olig3 plays different roles in regulating the development of dorsal and ventral spinal cord
Olig3 is specifically and transiently expressed in different types of progenitors of embryonic central nervous system and then disappears in the course of development
Olig3 expression distinguishes the two major classes of progenitors in the dorsal spinal cord and determines the distinct specification program of class A neurons.
dorsal Olig3 cells contribute to dorsal midline cells and commissural interneurons at intermediate and ventral levels
Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signals act upstream of Olig3 in the specification of dI2 and dI3 neurons.
Olig3 is specifically expressed in dorsal progenitor 1 domains of neural progenitor cells in the caudal hindbrain and regulates the fates of these neural progenitor cells.
The fate of class A neurons was not correctly determined in Olig3 mutants. As a consequence, the nucleus of the solitary tract did not form, and precerebellar nuclei, such as the inferior olivary nucleus, were absent or small.
May determine the distinct specification program of class A neurons in the dorsal part of the spinal cord and suppress specification of class B neurons.
, oligodendrocyte transcription factor 3
, class B basic helix-loop-helix protein 7
, class E basic helix-loop-helix protein 20
, basic helix-loop-helix domain-containing class B protein 7
, oligodendrocyte-specific bHLH transcription factor 3
, oligodendrocyte transcription factor 2
, bHLH transcription factor Olig2
, oligodendrocyte lineage transcription factor 2