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Promotes formation and maturation of oligodendrocytes, especially within the brain.
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Olig1 has a critical function in regulation of postnatal neural progenitor cell production in response to Noggin (zeige NOG Proteine).
This study demonstrated that increased expression of mRNA of OLIG1 in ventral prefrontal white matter in major depressive disorder.
Olig1 is a Smad (zeige SMAD1 Proteine) cofactor involved in TGF-beta (zeige TGFB1 Proteine)-induced cell motility
This study review OLIG1 have developmental functions in patterning, neuron subtype specification and the formation of oligodendrocytes and play the role in the postnatal brain during repair processes and in neurological disease states.
Olig1 was not expressed in freshly isolated oligodendrocytes, but is expressed from the beginning of process extension until membrane maintenance.
analysis of conserved and non-conserved functional elements at the Olig1 and Olig2 (zeige OLIG2 Proteine) locus
Olig1 and Olig2 (zeige OLIG2 Proteine) transcription factors in the human central nervous system are important not only for differentiation of the oligodendrocyte lineage, but they may also have a role in neural cell specification.
identified novel coding variants in the Olig1 gene, including a trinucleotide repeat, but found no evidence to support the hypothesis that genetic variation in Olig1 influences susceptibility to multiple sclerosis
Mutations in OLIG1 and OLIG2 (zeige OLIG2 Proteine) are not likely to be associated with this subgroup of hypomyelinating disorders.
OLIG1 protein expression significantly correlates with overall survival in non-small cell lung cancer patients
found that many of the Olig2 (zeige OLIG2 Proteine)-bound sites were associated with genes with biological processes corresponding to OL differentiation (Nkx2.2 (zeige Nkx2-2 Proteine), Nkx6.2, and Sip1 (zeige ZEB2 Proteine)), myelination and ensheathment (Mbp (zeige MBP Proteine), Cldn11 (zeige CLDN11 Proteine), and Mobp (zeige MOBP Proteine)), as well as cell cycle and cytoskeletal regulation
the dynamic interplay between HMGNs and H1 in chromatin epigenetically regulates the expression of OLIG1&2, thereby affecting oligodendrocyte development and myelination, and mouse behavior.
Olig1 begins to be expressed at the ventral domain of the otocyst at embryonic day (E) 9.5, and Olig1 expression in the epithelium of the developing inner ear persists to E15.5.
These studies establish that acetylation of Olig1 regulates its chromatin dissociation and subsequent translocation to the cytoplasm and is required for its function in oligodendrocyte maturation.
The current study demonstrates a unique role for Olig1 in promoting oligodendrocyte progenitor cell commitment, differentiation, and subsequent myelination primarily in brain, but not spinal cord.
Our findings support the original conclusion that Olig1 plays a minor and non-essential role in oligodendrocyte development.
The results of this study establish Olig1 as an essential repressor of Dlx1/2 and interneuron production in developing mammalian brain.
Our results suggest a novel role for a phosphorylated cytosolic Olig1 in membrane expansion and maturation of oligodendrocytes.
Promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube (By similarity).
oligodendrocyte transcription factor 1
, basic domain, helix-loop-helix protein, class B, 6
, class B basic helix-loop-helix protein 6
, class E basic helix-loop-helix protein 21
, oligodendrocyte lineage transcription factor 1
, oligodendrocyte-specific bHLH transcription factor 1
, Olg-1 bHLH protein