Nucleolar Protein 3 (Apoptosis Repressor with CARD Domain) Proteine (NOL3)

NOL3 encodes an anti-apoptotic protein that has been shown to down-regulate the enzyme activities of caspase 2, caspase 8 and tumor protein p53.

alle Proteine anzeigen Gen GeneID UniProt
Human NOL3 NOL3 8996 O60936
Maus NOL3 NOL3 78688 Q9D1X0
Ratte NOL3 NOL3 85383 Q62881
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Showing 8 out of 12 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$5,960.83
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Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$5,960.83
Details
Escherichia coli (E. coli) Human His tag   50 μg Anmelden zum Anzeigen 4 Days
$385.00
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Escherichia coli (E. coli) Human His tag Validation with Western Blot 10 μg Anmelden zum Anzeigen 8 bis 11 Tage
$394.90
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$547.80
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 15 bis 19 Tage
$400.00
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Escherichia coli (E. coli) Human GST tag   10 μg Anmelden zum Anzeigen 15 bis 16 Tage
$225.00
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Weitere Proteine zu Nucleolar Protein 3 (Apoptosis Repressor with CARD Domain) (NOL3) Interaktionspartnern

Human Nucleolar Protein 3 (Apoptosis Repressor with CARD Domain) (NOL3) Interaktionspartner

  1. Results show that in response to DNA damage, p53 (zeige TP53 Proteine) total levels increase proportionally to the strength of the damage; however, p53 (zeige TP53 Proteine) tetramers are formed at a constant rate under the control of ARC protein.

  2. role of apoptosis repressor with a CARD domain (ARC) in the therapeutic resistance of renal cell carcinoma (zeige MOK Proteine)

  3. a novel genetic primary myelofibrosis-like mouse model and identify a tumor suppressor role for NOL3 in the pathogenesis of myeloid malignancies.

  4. Increased ARC expression is associated with liver metastasis of colorectal cancer.

  5. RUNX3 (zeige RUNX3 Proteine), miR (zeige MLXIP Proteine)-185 and ARC regulate the sensitivity of gastric cancer cells to chemotherapy.

  6. ARC is regulated via BIRC2 (zeige BIRC2 Proteine)/MAP3K14 (zeige MAP3K14 Proteine) signalling and its overexpression in AML (zeige RUNX1 Proteine) or MSCs can function as a resistant factor to birinapant-induced leukaemia cell death.

  7. high expression of ARC plays an important role in the pathogenesis of nasopharyngeal carcinoma and leads to X-radiation and cisplatin resistance in nasopharyngeal carcinoma.

  8. ARC is a previously unrecognized inhibitor of apoptosis in beta-cells and that its protective effects are mediated through suppression of the ER stress response pathway.

  9. This study utilized unbiased, genome-wide approaches to identify a NOL3 mutation that likely causes Familial cortical myoclonus.

  10. HIF-1alpha (zeige HIF1A Proteine) directly bound to hypoxia-responsive element located at -419 to -414 of ARC gene, which is essential for HIF-1 (zeige HIF1A Proteine)-induced expression.

Mouse (Murine) Nucleolar Protein 3 (Apoptosis Repressor with CARD Domain) (NOL3) Interaktionspartner

  1. Data suggest that reduced levels of apoptosis repressor with caspase recruitment domain protein (ARC) might correlate with neomycin-induced hair cells (HCs (zeige HLCS Proteine)) loss.

  2. Although mice lacking Men1 developed insulinomas as expected, elimination of ARC in this context did not significantly alter tumor load. Cellular rates of proliferation and death in these tumors were also not perturbed in the absence of ARC.

  3. interaction of ARC with TNF (zeige TNF Proteine) receptor 1 Interferes with recruitment of RIP1 (zeige RALBP1 Proteine), a critical mediator of TNFalpha (zeige TNF Proteine)-induced regulated necrosis.

  4. Arc deficiency in dystrophic muscle exacerbates disease pathogenesis due to a Bax (zeige BAX Proteine)-mediated sensitization of mitochondria-dependent death mechanisms

  5. ARC is a previously unrecognized inhibitor of apoptosis in beta-cells and that its protective effects are mediated through suppression of the ER stress response pathway.

  6. Data show that ARC promotes breast carcinogenesis by driving primary tumor growth, invasion, and metastasis as well as by promoting chemoresistance in invasive cells.

  7. ARC, previously unlinked to pulmonary hypertension, is a critical determinant of vascular remodeling in this syndrome.

  8. On biomechanical stress induced by aortic banding, ARC-deficient mice developed accelerated cardiomyopathy, which was characterized by reduced contractile function, cardiac enlargement, and myocardial fibrosis

  9. catalase (zeige CAT Proteine), CK2 (zeige CSNK2A1 Proteine), and ARC constitute an anti-hypertrophic pathway in the heart.

  10. endogenous nociceptin differentially modulates diet preference depending on macronutrient content and homeostatic state, independently of the motivating, rewarding or orosensory properties of food, but may involve metabolic or postingestive processes.

Nucleolar Protein 3 (Apoptosis Repressor with CARD Domain) (NOL3) Protein Überblick

Protein Überblick

This gene encodes an anti-apoptotic protein that has been shown to down-regulate the enzyme activities of caspase 2, caspase 8 and tumor protein p53. Multiple transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit NOL3

  • nucleolar protein 3 (NOL3)
  • nucleolar protein 3 (apoptosis repressor with CARD domain) (Nol3)
  • nucleolar protein 3 (Nol3)
  • nucleolar protein 3 (apoptosis repressor with CARD domain) (NOL3)
  • Arc Protein
  • B430311C09Rik Protein
  • FCM Protein
  • MYC Protein
  • MYP Protein
  • NOP Protein
  • Nop30 Protein

Bezeichner auf Proteinebene für NOL3

muscle-enriched cytoplasmic protein , nucleolar protein 3 , nucleolar protein of 30 kDa , apoptosis repressor with CARD

GENE ID SPEZIES
8996 Homo sapiens
78688 Mus musculus
85383 Rattus norvegicus
611249 Canis lupus familiaris
515777 Bos taurus
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