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NSMAF encodes a WD-repeat protein that binds the cytoplasmic sphingomyelinase activation domain of the 55kD tumor necrosis factor receptor.
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The interaction of FAN with receptor for activated C-kinase 1 (RACK1 (zeige GNB2L1 Antikörper)) appears to be dependent on the folding of the WD repeats into a secondary structure, because no linear binding motifs are identified in the WD-repeat region of FAN.
sphingolipid activator proteins like domain may stabilize the fold of acid sphingomyelinase (zeige SMPD1 Antikörper)
Regulation of NSMAF by TNF-alpha (zeige TNF Antikörper) involves PRKCD (zeige PKCd Antikörper) in lung epithelial cells.
FAN through promoting melanoma cellular motility and tumour invasiveness is critical for the tumour-promoting action of tumor necrosis factor (zeige TNF Antikörper).
FAN is not implicated in the development of methionine and choline deficient diet-induced non-alcoholic steatohepatitis.
the role of FAN and IL-6 (zeige IL6 Antikörper) in the inflammatory response initiated by endotoxin, implicating TNFalpha (zeige TNF Antikörper)
FAN mediates activation of N-SMase as well as regulation of lysosome size by signaling pathways that operate independent from activation/membrane recruitment of PKC.
The results of this study suggest that PH-mediated plasma membrane targeting of FAN is critically involved in tumor necrosis factor (zeige TNF Antikörper)-induced Cdc42 (zeige CDC42 Antikörper) activation and cytoskeleton reorganization.
This is the first report to demonstrate that TNFalpha (zeige TNF Antikörper)-induced sickness behavior is fully mediated by TNF-R1 (zeige TNFRSF1A Antikörper) and that the adaptor protein FAN is a necessary intracellular intermediate for sickness behavior
these results indicate the involvement of FAN in TNF (zeige TNF Antikörper)-induced gene expression and leukocyte recruitment, contributing to the establishment of the specific immune response.
This gene encodes a WD-repeat protein that binds the cytoplasmic sphingomyelinase activation domain of the 55kD tumor necrosis factor receptor. This protein is required for TNF-mediated activation of neutral sphingomyelinase and may play a role in regulating TNF-induced cellular responses such as inflammation. Alternative splicing results in multiple transcript variants.
, factor associated with N-SMase activation
, factor associated with neutral sphingomyelinase activation