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The protein encoded by NXT1 is located in the nuclear envelope. Zusätzlich bieten wir Ihnen NXT1 Antikörper (33) und viele weitere Produktgruppen zu diesem Protein an.
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in Drosophila primary spermatocytes, the transcription factor used to activate expression of a transcript, rather than the RNA sequence itself or the core transcription machinery, determines whether this expression requires Nxt1
Here, the authors identify cellular nuclear transport factor 2 (NTF2 (zeige NUTF2 Proteine))-like export protein 1 (NXT1) as a novel binding partner of nucleoprotein (NP) that stimulates NP-mediated nuclear export via the CRM1 (zeige XPO1 Proteine)-dependent pathway.
Complementary structural, biochemical and cellular techniques indicated that the formation of a symmetric RNA binding platform generated by dimerization of NXF1 (zeige NXF1 Proteine):NXT1 facilitates the recognition of CTE-RNA and promotes its nuclear export
regulation of tumor necrosis factor-alpha (zeige TNF Proteine) mRNA nucleocytoplasmic transport by ERK (zeige EPHB2 Proteine) map kinases requires TAP-NxT1 binding and the AU-rich element
The protein encoded by this gene is located in the nuclear envelope. It has protein similarity to nuclear transport factor 2. This protein functions as a nuclear export factor in both RAN (Ras-related nuclear protein)- and CRM1 (required for chromosome region maintenance)-dependent pathways. It is found to stimulate the export of U1 snRNA in RAN- and CRM1-dependent pathways and the export of tRNA and mRNA in a CRM1-independent pathway. The encoded protein heterodimerizes with Tap protein and may regulate the ability of Tap protein to mediate nuclear mRNA export. The use of alternate polyadenylation sites has been found for this gene.
, NTF2-related export protein 1
, NTX2-like export factor1
, NUTF-like export factor 1
, protein p15