N-Acylsphingosine Amidohydrolase (Non-Lysosomal Ceramidase) 2 Proteine (ASAH2)

Ceramidases (EC 3.5.1.23), such as ASAH2, catalyze hydrolysis of the N-acyl linkage of ceramide, a second messenger in a variety of cellular events, to produce sphingosine. Zusätzlich bieten wir Ihnen ASAH2 Antikörper (60) und ASAH2 Kits (5) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
ASAH2 56624 Q9NR71
Ratte ASAH2 ASAH2 114104 Q91XT9
ASAH2 54447 Q9JHE3
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Showing 4 out of 8 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Human Cells Maus His tag 10 μg Anmelden zum Anzeigen 20 bis 21 Tage
$206.80
Details
Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 60 bis 65 Tage
$10,888.92
Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 60 bis 65 Tage
$7,639.51
Details
Escherichia coli (E. coli) Human Unkonjugiert   100 μg Anmelden zum Anzeigen 11 bis 18 Tage
$582.75
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ASAH2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
,
Mouse (Murine) ,
,

Weitere Proteine zu N-Acylsphingosine Amidohydrolase (Non-Lysosomal Ceramidase) 2 (ASAH2) Interaktionspartnern

Human N-Acylsphingosine Amidohydrolase (Non-Lysosomal Ceramidase) 2 (ASAH2) Interaktionspartner

  1. The structural basis for ceramide recognition and hydrolysis by human neutral ceramidase has been uncovered.

  2. These results demonstrate for the first time that adiponectin inhibits TNFalpha (zeige TNF Proteine)-induced inflammatory response via Cav1 (zeige CAV1 Proteine)-mediated ceramidase recruitment and activation in an AdipoR1 (zeige ADIPOR1 Proteine)-dependent fashion.

  3. cloned a 3000 bp region upstream of the translational start site of the nCDase gene

  4. c-Jun/AP-1 (zeige JUN Proteine) signaling may, in part, regulate serum-induced nCDase gene transcription

  5. Both acidic ceramidase (aCDase) and neutral ceramidase (nCDase) activities declined after low- and high-UVB, but returned to normal only in low-UVB cells

  6. Blocking acid ceramidase (zeige ASAH1 Proteine) but not sphingosine kinase activity in alveolar macrophages led to decreased ERK (zeige EPHB2 Proteine) and Akt (zeige AKT1 Proteine) activity and induction of cell death.

  7. Neutral ceramidase is localized mainly in plasma membranes.

  8. the present study identified a novel amidase (zeige GATA1 Proteine) sequence containing a critical serine residue that may function as a nucleophile in the hydrolytic attack on the amide bond present in ceramide

  9. Important for the generation of sphgosine 1 phosphqte (S1P (zeige MBTPS1 Proteine)) and S1P (zeige MBTPS1 Proteine)-mediated cell proliferation and survival.

  10. the purification and characterization of neutral ceramidase from human ileostomy content, using octanoyl-[(14)C]sphingosine as substrate

Mouse (Murine) N-Acylsphingosine Amidohydrolase (Non-Lysosomal Ceramidase) 2 (ASAH2) Interaktionspartner

  1. These results suggest that neutral ceramidase is a mediator of necroptosis and might be a novel therapeutic target for protection from ischaemic injury.

  2. Knocking down NCDase reduced sphingosine accumulation in mitochondria and preserved COX (zeige CPOX Proteine) activity after the brain injury.

  3. Neutral ceramidase deficiency increases inflammation in a mouse model of inflammatory bowel disease.

  4. Novel pathway of ceramide production in mitochondria: thioesterase (zeige FASN Proteine) and neutral ceramidase produce ceramide from sphingosine and acyl-CoA (zeige GNPAT Proteine).

  5. the predicted HNF-4alpha binding site identified in the Asah2 promoter is functional

  6. molecular cloning of the mouse neutral ceramidase gene and its promoter analysis

  7. Neutral ceramidase secreted by endothelial cells is released in part associated with caveolin-1 (zeige CAV1 Proteine).

  8. the Asah2-encoded neutral ceramidase is a key enzyme for the catabolism of dietary sphingolipids and regulates the levels of bioactive sphingolipid metabolites in the intestinal tract

  9. This enzyme is decreased in the small intestine in CFTR (zeige CFTR Proteine) transgenic mice with a deletion in CFTR (zeige CFTR Proteine)>

ASAH2 Protein Überblick

Protein Überblick

Ceramidases (EC 3.5.1.23), such as ASAH2, catalyze hydrolysis of the N-acyl linkage of ceramide, a second messenger in a variety of cellular events, to produce sphingosine. Sphingosine exerts both mitogenic and apoptosis-inducing activities, and its phosphorylated form functions as an intra- and intercellular second messenger (see MIM 603730) (Mitsutake et al., 2001

Genbezeichner und Symbole assoziert mit ASAH2

  • N-acylsphingosine amidohydrolase 2 (ASAH2)
  • N-acylsphingosine amidohydrolase 2 (Asah2)
  • AI585898 Protein
  • BCDase Protein
  • HNAC1 Protein
  • LCDase Protein
  • N-CDase Protein
  • NCDase Protein

Bezeichner auf Proteinebene für ASAH2

N-acylsphingosine amidohydrolase 2 , acylsphingosine deacylase 2 , mitochondrial ceramidase , neutral ceramidase , neutral/alkaline ceramidase , non-lysosomal ceramidase , N-CDase , NCDase

GENE ID SPEZIES
56624 Homo sapiens
114104 Rattus norvegicus
486461 Canis lupus familiaris
54447 Mus musculus
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