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Ceramidases (EC 220.127.116.11), such as ASAH2, catalyze hydrolysis of the N-acyl linkage of ceramide, a second messenger in a variety of cellular events, to produce sphingosine. Zusätzlich bieten wir Ihnen ASAH2 Antikörper (60) und ASAH2 Kits (5) und viele weitere Produktgruppen zu diesem Protein an.
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The structural basis for ceramide recognition and hydrolysis by human neutral ceramidase has been uncovered.
These results demonstrate for the first time that adiponectin inhibits TNFalpha (zeige TNF Proteine)-induced inflammatory response via Cav1 (zeige CAV1 Proteine)-mediated ceramidase recruitment and activation in an AdipoR1 (zeige ADIPOR1 Proteine)-dependent fashion.
cloned a 3000 bp region upstream of the translational start site of the nCDase gene
c-Jun/AP-1 (zeige JUN Proteine) signaling may, in part, regulate serum-induced nCDase gene transcription
Both acidic ceramidase (aCDase) and neutral ceramidase (nCDase) activities declined after low- and high-UVB, but returned to normal only in low-UVB cells
Blocking acid ceramidase (zeige ASAH1 Proteine) but not sphingosine kinase activity in alveolar macrophages led to decreased ERK (zeige EPHB2 Proteine) and Akt (zeige AKT1 Proteine) activity and induction of cell death.
Neutral ceramidase is localized mainly in plasma membranes.
the present study identified a novel amidase (zeige GATA1 Proteine) sequence containing a critical serine residue that may function as a nucleophile in the hydrolytic attack on the amide bond present in ceramide
Important for the generation of sphgosine 1 phosphqte (S1P (zeige MBTPS1 Proteine)) and S1P (zeige MBTPS1 Proteine)-mediated cell proliferation and survival.
the purification and characterization of neutral ceramidase from human ileostomy content, using octanoyl-[(14)C]sphingosine as substrate
These results suggest that neutral ceramidase is a mediator of necroptosis and might be a novel therapeutic target for protection from ischaemic injury.
Knocking down NCDase reduced sphingosine accumulation in mitochondria and preserved COX (zeige CPOX Proteine) activity after the brain injury.
Neutral ceramidase deficiency increases inflammation in a mouse model of inflammatory bowel disease.
Novel pathway of ceramide production in mitochondria: thioesterase (zeige FASN Proteine) and neutral ceramidase produce ceramide from sphingosine and acyl-CoA (zeige GNPAT Proteine).
the predicted HNF-4alpha binding site identified in the Asah2 promoter is functional
molecular cloning of the mouse neutral ceramidase gene and its promoter analysis
Neutral ceramidase secreted by endothelial cells is released in part associated with caveolin-1 (zeige CAV1 Proteine).
the Asah2-encoded neutral ceramidase is a key enzyme for the catabolism of dietary sphingolipids and regulates the levels of bioactive sphingolipid metabolites in the intestinal tract
This enzyme is decreased in the small intestine in CFTR (zeige CFTR Proteine) transgenic mice with a deletion in CFTR (zeige CFTR Proteine)>
Ceramidases (EC 18.104.22.168), such as ASAH2, catalyze hydrolysis of the N-acyl linkage of ceramide, a second messenger in a variety of cellular events, to produce sphingosine. Sphingosine exerts both mitogenic and apoptosis-inducing activities, and its phosphorylated form functions as an intra- and intercellular second messenger (see MIM 603730) (Mitsutake et al., 2001
N-acylsphingosine amidohydrolase 2
, acylsphingosine deacylase 2
, mitochondrial ceramidase
, neutral ceramidase
, neutral/alkaline ceramidase
, non-lysosomal ceramidase