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Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Zusätzlich bieten wir Ihnen Mitochondrially Encoded NADH Dehydrogenase 4 Antikörper (5) und viele weitere Produktgruppen zu diesem Protein an.
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This review focuses on the role of mitochondrial genes in causing LHON and therapeutics available for treating the disease. A systematic search has been adopted in various databases using the keywords "LHON," "mitochondria," "ND1," "ND4," "ND6," and "therapy" and the following review on mitochondrial genetics.
A missense mutation, m.11778G>A (p.R340H), in the ND4 gene was identified in eight patients and three asymptomatic carriers, even though the incidence of this has been considered low in Chinese population.
MT-ND4 and MT-TL1 (zeige TNFSF15 Proteine) genetic variation might be associated with male infertility in Chinese patients.
this paper identified m.11240C4T in ND4 as a novel mitochondrial disease-related mtDNA mutation in Leigh syndrome.
We identified a genetic association between the MT-ND4 11719 A/G polymorphism and Ulcerative Colitis in the subgroup of males. The male-specific association indicates differences between males and females concerning the impact of mitochondrial gene polymorphisms on the development of Ulcerative Colitis.
The molecular study of a family with one member with Leber hereditary optic neuropathy found the mitochondrial mutation m.11778G>A in MT-ND4.
the ND4 gene is the hot spot for mutations associated with Leber's hereditary optic neuropathy
Three mutations were significantly related to the presence of epilepsy. These mutations were found at the 8502, 11994, and 13,231 bp of mtDNA, which resulted in amino acid changes at the MT-ATP-8 (zeige MT-ATP8 Proteine), MT-ND4 and MT-ND5 (zeige MT-ND5 Proteine) genes.
Expression of WT human ND4 in cells with the G11778A mutation in ND4 led to restoration of defective ATP synthesis.
altered activity of complex III modulates the phenotypic manifestation of Leber's hereditary optic neuropathy-associated ND4 G11778A mutation
Cybrid mice showed normal respiratory function whether or not their mtDNA possessed the A11181G mutation of the mt-Nd4 gene, suggesting that the this mutation is not responsible for respiration defects found in SAMP8 mice.
Data indicate that SLOW GROWTH 4 (SLO4) is a mitochondrial pentatricopeptide repeat (PPR) protein that is involved in editing NADH dehydrogenase subunit 4 (nad4), possibly required for the efficient splicing of NADH dehydrogenase subunit 2 (nad2) intron1.
The data supports a model for MTSF1 functioning in which its association with the last nucleotides of the nad4 3' untranslated region stabilizes nad4 mRNA.
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
NADH dehydrogenase subunit 4