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MIIP encodes a protein that interacts with the oncogene protein insulin-like growth factor binding protein 2 and may function as an inhibitor of cell migration and invasion. Zusätzlich bieten wir Ihnen MIIP Antikörper (38) und MIIP Kits (6) und viele weitere Produktgruppen zu diesem Protein an.
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Data show that protein kinase C epsilon (PKCepsilon (zeige PRKCE Proteine)) phosphorylates migration and invasion inhibitory protein (MIIP) at Ser303 and promotes its binding to RelA/p65 (zeige NFkBP65 Proteine), facilitating colorectal cancer metastasis.
MIIP may function as a tumor suppressor gene for endometrial carcinoma. MIIP attenuates Rac1 signaling through a protein interaction network, and loss of this regulator may contribute to EC metastasis.
MIIP haploinsufficiency induces chromosomal instability and promotes tumour progression in colorectal cancer.
MIIP expression in esophageal squamous-cell carcinoma tissues was increased significantly in comparison with the paired paracancerous normal epithelia and was associated with cell differentiation. Patients with low MIIP expression had improved overall and disease-free survival. MIIP expression was an independent prognostic factor in ESCC OS and DFS (zeige FST Proteine).
MIIP attenuates mitotic transition and increases mitotic catastrophe, thereby inhibiting glioma development and progression.
Data show a novel mechanism by which IIp45 inhibits cell motility through inhibition of HDAC6 (zeige HDAC6 Proteine).
Results suggest MIIP K167E as a functional genetic marker of breast cancer development and prognosis.
identified a gene, invasion inhibitory protein 45 (IIp45), whose protein product bound to IGFBP-2 through the thyroglobulin (zeige TG Proteine)-RGD region of the C terminus of IGFBP-2
IIp45 gene is inactivated by a tumor-specific alternative splicing that generates an aberrant and unstable IIp45 isoform in infiltrative gliomas.
This gene encodes a protein that interacts with the oncogene protein insulin-like growth factor binding protein 2 and may function as an inhibitor of cell migration and invasion. This protein also interacts with the cell division protein 20 and may be involved in regulating mitotic progression. This protein may function as a tumor suppressor by inhibiting the growth or certain cancers.
, invasion-inhibitory protein 45
, migration and invasion-inhibitory protein
, invasion inhibitory protein 45
, IGFBP-2-Binding Protein, IIp45