Matrix Metallopeptidase 13 (Collagenase 3) Proteine (MMP13)

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Zusätzlich bieten wir Ihnen Matrix Metallopeptidase 13 (Collagenase 3) Antikörper (289) und Matrix Metallopeptidase 13 (Collagenase 3) Kits (145) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
MMP13 4322 P45452
MMP13 17386 P33435
MMP13 171052  
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Showing 10 out of 41 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$4,744.22
Details
Escherichia coli (E. coli) Human Unkonjugiert 10 μg Anmelden zum Anzeigen 6 bis 7 Tage
$465.95
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Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$4,744.22
Details
Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$688.00
Details
Escherichia coli (E. coli) Maus His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$752.00
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Escherichia coli (E. coli) Ratte His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$778.00
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Escherichia coli (E. coli) Kaninchen His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$826.00
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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HEK-293 Cells Ratte His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$1,520.00
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Insect cells (Sf9) Human Unkonjugiert 10 μg Anmelden zum Anzeigen 2 bis 3 Tage
$345.00
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MMP13 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, ,
Mouse (Murine)

Rat (Rattus) , ,

Weitere Proteine zu Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) Interaktionspartnern

Human Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) Interaktionspartner

  1. Transfection of cells with either miR (zeige MLXIP Proteine)-100 or miR (zeige MLXIP Proteine)-125b negated the induction of MMP13 release. Additionally, AR activation induced a morphological alteration of MDA-MB-453 cells, which was blocked by miR (zeige MLXIP Proteine)-125b only.

  2. ATM (zeige ATM Proteine) could be activated by lung cancer-associated TNF-alpha (zeige TNF Proteine), up-regulate MMP-13 expression and thereby augment tumor metastasis

  3. The Sp1 (zeige PSG1 Proteine)-mediaded allelic regulation of MMP13 expression by an esophageal squamous cell carcinoma susceptibility SNP rs2252070 has been demonstrated.

  4. MMP-13 IRS (zeige IARS Proteine) represents a suitable method to assess pathologic grade of precancerous and cancerous colorectal lesions. MMP-13 has been identified as an excellent marker of high grade IEN and CRC (zeige CALR Proteine), and may thus be applied for prognostic stratification.

  5. These findings suggest that using MMP-13 inhibitors in diffuse group might contribute to the control of tumor growth

  6. The present results suggested that Icariin may have a chondroprotective effect, exerted through the inhibition of MMP1 (zeige MMP1 Proteine), MMP3 (zeige MMP3 Proteine) and MMP13 via MAPK (zeige MAPK1 Proteine) pathways. Therefore, Icariin may have potential as a novel therapeutic strategy for the treatment of osteoarthritis.

  7. MMP-13 may play a role on physiological turnover of cartilage extracellular matrix and that LRP1 (zeige LRP1 Proteine) is a key modulator of extracellular levels of MMP-13 and its internalization is independent of the levels of ADAMTS-4 (zeige ADAMTS4 Proteine), -5 and TIMP-3 (zeige TIMP3 Proteine).

  8. proteolysis of collagen-rich natural extracellular matrix (ECM (zeige MMRN1 Proteine)), performed uniquely by individual homologous proteases, leads to distinct events that eventually affect overall ECM (zeige MMRN1 Proteine) morphology, viscoelastic properties, and molecular composition.

  9. A strong association between the -77 MMP-13 polymorphism and posterior tibial tendinopathy insufficiency.

  10. Data show that AJUBA (zeige AJUBA Proteine) upregulated MMP10 (zeige MMP10 Proteine) and MMP13 expression in esophageal squamous cell carcinoma (ESCC).

Mouse (Murine) Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) Interaktionspartner

  1. that MMP-13 is a central protease in infarct development and cortical remodeling during post-stroke neurorepair

  2. the phenotype seen in the Hdac4 (zeige HDAC5 Proteine)(-/-) mice is partially derived from elevation in MMP-13 and may be due to a bone remodeling disorder caused by overexpression of this enzyme.

  3. MEF2C (zeige MEF2C Proteine) is necessary for Mmp13 gene expression at the transcriptional level and participates in PTH (zeige PTH Proteine)-stimulated Mmp13 gene expression by increased binding to c-FOS at the AP-1 (zeige JUN Proteine) site in the Mmp13 promoter.

  4. data reveal a novel involvement of MMP-13 in regulating dendritic cell (DC) immunobiology through moderating MHC-I surface presentation, endocytosis and cytokine/chemokine (zeige CCL1 Proteine) secretion; furthermore, the reduced MHC-I surface presentation by DCs resulted in a poor CD8 (zeige CD8A Proteine)(+) T-cell response in vitro; MMP-13 might be a promising target for therapeutic intervention in inflammatory diseases

  5. The progressive process of articular cartilage degeneration was significantly delayed in the knee joints of Ddr2 (zeige DDR2 Proteine)-deficient mice in comparison to their control littermates. Articular cartilage damage in the knee joints of the mice was associated with increased expression profiles of both Ddr2 (zeige DDR2 Proteine) and matrix metalloproteinase 13.

  6. Postnatal chondrocyte-specific deletion of Hdac3 (zeige HDAC3 Proteine) with an inducible Col2a1 (zeige COL2A1 Proteine)-Cre caused premature production of pErk1/2 and Mmp13 in the growth plate.

  7. Mmp13 is selectively regulated of by 1,25-Dihydroxyvitamin D3, PTH (zeige PTH Proteine), and Osterix (zeige SP7 Proteine) through distal enhancers.

  8. Our study contributes to the understanding of the role of HIF1alpha (zeige HIF1A Proteine) in OA and highlights the HIF1alpha (zeige HIF1A Proteine)-beta-catenin (zeige CTNNB1 Proteine) interaction, thus providing new insights into the impact of hypoxia in articular cartilage.

  9. Matrix metalloproteinases (MMP) are effectors of hippocampal neuroplasticity in the adult central nervous system and that the MMP-1 (zeige MMP1 Proteine)/protease-activated receptor-1 (zeige F2R Proteine) axis may play a role in neurogenesis following physiological and/or pathological stimuli.

  10. IL-1Ra (zeige IL1RN Proteine) is associated with MMP-13 expression and has a novel function in such regulation without interference of the IL-1 (zeige IL1A Proteine) signaling cascade.

Cow (Bovine) Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) Interaktionspartner

  1. p38 (zeige MAPK14 Proteine) phosphorylation and MMP13 expression are regulated by Rho/ROCK activation, and support the potential novel pathway that Rho/ROCK is in the upper part of the mechanical stress-induced matrix degeneration cascade in cartilage.

  2. These data identify atypical PKC isozymes as STAT and ERK activators that mediate c-fos and collagenase expression.

  3. MMP-13 treatment of fresh articular cartilage results in cleaved fibromodulin (zeige FMOD Proteine) fragments

  4. increased in bovine preovulatory follicles following the gonadotropin surge but no up-regulation of MMP-1 (zeige MMP1 Proteine) and MMP-13 (follicular apex (zeige APEX1 Proteine) vs. base) for the preovulatory collagenolysis required for follicle rupture

  5. involvement of p38 MAP kinase (zeige MAPK14 Proteine) in the hyaluronan oligosaccharide induction of MMP-13

  6. MMP-13 and collagenase have roles in chondrocyte hypertrophy induced by type II collagen (zeige COL2A1 Proteine)

  7. At high but naturally occurring concentrations the collagen peptide CB12-II induced an increase in the expressions of MMP-13 and cleavage of type II collagen (zeige COL2A1 Proteine) by collagenase in the mid zone and also in the superficial zone.

Xenopus laevis Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) Interaktionspartner

  1. XCL3 and XCL4 can be differentially induced by prolactin (zeige PRL Proteine) and thyroid hormone (zeige PTH Proteine)(3)

Zebrafish Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) Interaktionspartner

  1. MeHg impairs tail development at least partially by activation of the tissue remodeling proteases Mmp9 (zeige MMP9 Proteine) and Mmp13.

  2. Zebra fish embryogenesis requires MMP-13 and dexamethasone and hydrocortisone modulate the expression of this gene, leading to increased activity and potentially contributing to subsequent dysmorphogenesis.

  3. JNK (zeige MAPK8 Proteine)-Mmp13 signaling pathway plays an essential role in regulating the innate immune cell migration in response to severe injury in vivo

Rabbit Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) Interaktionspartner

  1. These results suggest that PEP-1-SIRT2 (zeige SIRT2 Proteine) promotes matrix metalloproteinases-induced dedifferentiation via ERK (zeige MAPK1 Proteine) signaling in articular chondrocytes.

  2. chitosan-pDNA nanoparticles encoding shRNA targeting MMP-3 (zeige MMP3 Proteine) and -13 had great potential in silencing the dedifferentiation-related genes for regenerating prolonged and endurable cartilage.

  3. Leptin (zeige LEP Proteine) can induce MMP-13 and have a synergistic induction effect on NO with TNF-alpha (zeige TNF Proteine) in rabbit articular chondrocytes in vitro.

Horse (Equine) Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) Interaktionspartner

  1. The DNA microarray analysis for matrix metalloproteinase (MMP)-related mRNA expression in equine superficial digital flexor tendinitis indicated that mRNA level of MMP-13 was apparently up-regulated in the tendinitis as compared to normal tendon.

Pig (Porcine) Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) Interaktionspartner

  1. TNF-alpha (zeige TNF Proteine) induced MMP-13 expression by condylar cells might be involved in the degradation of the juvenile condyle.

Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) Protein Überblick

Protein Überblick

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.

Genbezeichner und Symbole assoziert mit MMP13

  • matrix metallopeptidase 13 (MMP13)
  • matrix metallopeptidase 13 (Mmp13)
  • matrix metalloproteinase 7 (MGC68994)
  • matrix metallopeptidase 13a (mmp13a)
  • matrix metallopeptidase 13 (collagenase 3) like S homeolog (mmp13l.S)
  • matrix metallopeptidase 13 (collagenase 3) (mmp13)
  • matrix metalloproteinase 13 (LOC100136348)
  • matrix metallopeptidase 12 (MMP12)
  • matrix metalloproteinase 13 (mmp13)
  • matrix metallopeptidase 13 (mmp13)
  • matrix metallopeptidase 13 (collagenase 3) like L homeolog (mmp13l.L)
  • cb1034 Protein
  • Clg Protein
  • CLG3 Protein
  • gene A Protein
  • MANDP1 Protein
  • MGC108008 Protein
  • MMP-13 Protein
  • Mmp1 Protein
  • MMP13 Protein
  • xcl3 Protein
  • xCol Protein

Bezeichner auf Proteinebene für MMP13

MMP-13 , collagenase 3 , matrix metalloproteinase 13 (collagenase 3) , Collagenase-3 , collagenase-1 , interstitial collagenase , matrix metalloproteinase 13 , matrix metalloproteinase-13 , UMRCASE , collagenase-3 , MMPLg , MMPLh , gene 11 , matrix metallopeptidase 13 (collagenase 3) , gene A , collagenase 3-like

GENE ID SPEZIES
4322 Homo sapiens
17386 Mus musculus
171052 Rattus norvegicus
281914 Bos taurus
379552 Xenopus laevis
387293 Danio rerio
398056 Xenopus laevis
443113 Ovis aries
451513 Pan troglodytes
493679 Felis catus
613098 Xenopus (Silurana) tropicalis
703980 Macaca mulatta
100008685 Oryctolagus cuniculus
100009711 Equus caballus
100012553 Monodelphis domestica
100136348 Salmo salar
100396943 Callithrix jacchus
100462632 Pongo abelii
100526826 Ictalurus punctatus
100552256 Anolis carolinensis
100584961 Nomascus leucogenys
397346 Sus scrofa
397823 Xenopus laevis
395683 Gallus gallus
403763 Canis lupus familiaris
100731756 Cavia porcellus
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