Mannosyl (Beta-1,4-)-Glycoprotein beta-1,4-N-Acetylglucosaminyltransferase Proteine (MGAT3)

There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. Zusätzlich bieten wir Ihnen MGAT3 Antikörper (69) und MGAT3 Kits (12) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
MGAT3 17309  
MGAT3 4248 Q09327
Ratte MGAT3 MGAT3 29582 Q02527
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 50 bis 55 Tage
$7,626.01
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Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 50 bis 55 Tage
$5,355.45
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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MGAT3 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)
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Human ,
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Weitere Proteine zu Mannosyl (Beta-1,4-)-Glycoprotein beta-1,4-N-Acetylglucosaminyltransferase (MGAT3) Interaktionspartnern

Mouse (Murine) Mannosyl (Beta-1,4-)-Glycoprotein beta-1,4-N-Acetylglucosaminyltransferase (MGAT3) Interaktionspartner

  1. The MGAT3 and bisected complex N-glycans retard mouse mammary tumor progression; identification of key galectins that promote mammary tumor progression in mice is not straightforward because the galectin genes are expressed; and high levels of MGAT3.

  2. data suggest that Fut8 (zeige FUT8 Proteine)(-/-) mice adapted to oxidative stress, both ex vivo and in vivo, by inducing various genes including GnT-III, which may compensate for the loss of core fucose functions

  3. Mgat3 glycogene expression and GnT-III-mediated glycosylation, specifically on E-cadherin (zeige CDH1 Proteine), is a novel and major component of the Epithelial-Mesenchymal-Transition and the reverted process, Mesenchymal-Epithelial-Transition mechanism.

  4. Roles of N-acetylglucosaminyltransferase III in epithelial-to-mesenchymal transition induced by transforming growth factor beta1 (TGF-beta1 (zeige TGFB1 Proteine)) in epithelial cell lines

  5. GnT-III expression may be precisely regulated by the interplay of E-cadherin (zeige CDH1 Proteine)-catenin complex-mediated cell-cell adhesion and Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signaling

  6. upregulation of GnT-III in AD brains may represent an adaptive response to protect them from additional beta-amyloid production

  7. mice homozygous for the Mgat3T37 mutation that express truncated GlcNAc-TIII from two mutant alleles suffer neurological and other consequences

  8. beta1,4-N-acetylglucosaminyltransferase III inhibits the function of alpha5beta1 integrin

  9. An E-cadherin (zeige CDH1 Proteine)-dependent pathway plays a critical role in regulation of GnT-III expression; changes in GnT-III expression presumably contribute to intracellular signaling transduction during tissue development and homeostasis.

Human Mannosyl (Beta-1,4-)-Glycoprotein beta-1,4-N-Acetylglucosaminyltransferase (MGAT3) Interaktionspartner

  1. Novel insights into the epigenetic regulation of MGAT3/bisecting GlcNAc and demonstrate the importance of N-glycosylation in cancer progression.

  2. Data suggest that GNT-III expression regulates levels/activation of the heavily glycosylated Notch (zeige NOTCH1 Proteine) receptor involved in normal and malignant cell development; suppression of GNT-III in epithelial ovarian carcinoma cell lines results in down-regulation of Notch (zeige NOTCH1 Proteine) signaling that is more potent than pharmacologic blockage of Notch (zeige NOTCH1 Proteine) activation.

  3. MGAT3 expressed in cells stimulates lipid droplet growth. These findings provide additional evidence that MGAT3 likely functions as a triacylglycerol synthase in cells.

  4. Core-fucosylated tetra-antennary structures were decreased in quantity likely as a result of hypomethylated MGAT3 gene promoter followed by increased expression of this gene

  5. High expression of alpha2,6-sialylation on the cell surface could affect the anti-migratory role of GnT-III, which provides an insight into the mechanistic roles of GnT-III in tumor metastasis.

  6. Mgat3 plays an important role in early spontaneous miscarriage in humans.

  7. MGAT3 protein and gene expression in in uveal and cutaneous melanoma cells

  8. HS5 cells had significantly enhanced levels of bisecting N-glycans (catalyzed by MGAT3 whereas HS27a cells had enhanced levels of Galbeta1,4GlcNAc.

  9. GnT-III determines E-cadherin (zeige CDH1 Proteine)-mediated tumor suppression, and GnT-V (zeige MGAT5 Proteine) regulates E-cadherin (zeige CDH1 Proteine)-mediated tumor invasion.

  10. Roles of N-acetylglucosaminyltransferase III in epithelial-to-mesenchymal transition induced by transforming growth factor beta1 (TGF-beta1 (zeige TGFB1 Proteine)) in epithelial cell lines

MGAT3 Protein Überblick

Protein Überblick

There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. The enzyme encoded by this gene transfers a GlcNAc residue to the beta-linked mannose of the trimannosyl core of N-linked oligosaccharides and produces a bisecting GlcNAc. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Genbezeichner und Symbole assoziert mit MGAT3

  • mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase (MGAT3)
  • mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase a (mgat3a)
  • mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase L homeolog (mgat3.L)
  • mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase (mgat3)
  • mannoside acetylglucosaminyltransferase 3 (Mgat3)
  • mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase (Mgat3)
  • 1110038J12Rik Protein
  • AI848272 Protein
  • GNT-III Protein
  • GNT3 Protein
  • mgat3 Protein
  • zgc:112067 Protein

Bezeichner auf Proteinebene für MGAT3

beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase , mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase , beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like , N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III , glcNAc-T III , GlcNAc-T III , N-acetylglucosaminyltransferase III , GNT-III , mannoside acetyl glucosaminyltransferase 3

GENE ID SPEZIES
418013 Gallus gallus
470218 Pan troglodytes
481244 Canis lupus familiaris
520087 Bos taurus
553676 Danio rerio
703643 Macaca mulatta
100055333 Equus caballus
100090777 Ornithorhynchus anatinus
100381104 Xenopus laevis
100401747 Callithrix jacchus
100461728 Pongo abelii
100492491 Xenopus (Silurana) tropicalis
17309 Mus musculus
4248 Homo sapiens
29582 Rattus norvegicus
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