Mannose Receptor, C Type 2 Proteine (MRC2)

MRC2 encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. Zusätzlich bieten wir Ihnen MRC2 Antikörper (77) und MRC2 Kits (31) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
Ratte MRC2 MRC2 498011 Q4TU93
MRC2 9902 Q9UBG0
MRC2 17534 Q64449
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Top MRC2 Proteine auf antikoerper-online.de

Showing 6 out of 9 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 70 bis 75 Tage
$11,428.37
Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$13,984.89
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$814.00
Details
Escherichia coli (E. coli) Human T7 tag,His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$733.00
Details
Escherichia coli (E. coli) Maus Unkonjugiert   100 μg Anmelden zum Anzeigen 11 bis 18 Tage
$582.75
Details

MRC2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, , , ,
Mouse (Murine) ,
,

Weitere Proteine zu Mannose Receptor, C Type 2 (MRC2) Interaktionspartnern

Cow (Bovine) Mannose Receptor, C Type 2 (MRC2) Interaktionspartner

  1. A second loss-of-function mutation in the bovine mannose receptor C (MRC2) gene causes illegitimate receptor oligomerization, which is predicted to impair function of the MRC2 encoded protein, Endo180.

  2. The positional identification of a 2-bp deletion in the open reading frame of the MRC2 receptor causing the recessive Crooked (zeige LRP6 Proteine) Tail Syndrome in cattle, isdescribed.

Human Mannose Receptor, C Type 2 (MRC2) Interaktionspartner

  1. Endo180 knockdown in pancreatic stellate cells (PSCs) attenuated the invasive abilities of PSCs and co-cultured pancreatic cancer cells, and decreased the expression level of phosphorylated myosin light chain 2 (MLC2 (zeige MYL12B Proteine)).

  2. results provide a molecular mechanism to support the structural flexibility of uPARAP, and shed light on the structural flexibility of other members of the MR family

  3. A model of the ligand-binding region of uPARAP was obtained by molecular replacement.

  4. The positive correlation between suPLAUR expression and body mass index, suggests that leukocyte recruitment in obese tissue may be regulated, at least in part, through the splicing of the PLAUR (zeige PLAUR Proteine) transcript.

  5. Our findings identify sarcoma cell-resident uPARAP/Endo180 as a central player in the bone degeneration of advanced osteosarcoma

  6. Study identifies the interaction between lectin domain in Endo180 and CD147 as an Epithelial-to-mesenchymal transition suppressor and indicates that stabilization of this molecular complex improves prostate cancer survival rates.

  7. AGE-dependent modification of the basal lamina induces invasive behaviour in non-transformed prostate epithelial cells via Endo180 pathway linked to cancer progression.

  8. MRC2 is downregulated by UVA irradiation and reduces collagen internalization; this can be recovered by all-trans retinoic acid

  9. Our findings correlate for the first time impaired collagen uptake via Endo180 with the pericellular accumulation of collagen fragments during photoaging.

  10. TGFbeta1 (zeige TGFB1 Proteine)-Endo180-dependent collagen deposition is dysregulated at the tumour-stromal interface in bone metastasis.

Mouse (Murine) Mannose Receptor, C Type 2 (MRC2) Interaktionspartner

  1. Findings show that under in vivo conditions, uPARAP does not play a role in the phagocytic uptake of collagen fibrils by fibroblasts.

  2. Our findings identify sarcoma cell-resident uPARAP/Endo180 as a central player in the bone degeneration of advanced osteosarcoma

  3. AGE-dependent modification of the basal lamina induces invasive behaviour in non-transformed prostate epithelial cells via Endo180 pathway linked to cancer progression.

  4. uPARAP function in cutaneous wound repair

  5. Both uPARAP and MMP-2 (zeige MMP2 Proteine) take part in matrix turnover processes important for bone growth.

  6. Genetic ablation of the Mrc2 impaired the intracellular collagen degradation pathway.

  7. This function of uPARAP/Endo180 defines a novel role of intracellular collagen turnover in fibrosis protection.

  8. uPARAP is highly expressed in the murine lung, and loss of uPARAP leads to differences in lung mechanics, lung permeability, and collagen content after injury

  9. data establish an important fibrosis-attenuating role for Mrc2-expressing renal interstitial cells and suggest the involvement of a lysosomal collagen turnover pathway

  10. A novel functional role of collagen glycosylation: interaction with the endocytic collagen receptor (zeige ITGA2 Proteine) uparap/ENDO180.

MRC2 Protein Überblick

Protein Überblick

This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands. Expression of this gene may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic bone disease.

Genbezeichner und Symbole assoziert mit MRC2

  • mannose receptor C type 2 (MRC2)
  • mannose receptor, C type 2 (mrc2)
  • mannose receptor C type 2 (mrc2)
  • mannose receptor, C type 2 (Mrc2)
  • CD280 Protein
  • CLEC13E Protein
  • ENDO180 Protein
  • mKIAA0709 Protein
  • MRC2 Protein
  • uPARAP Protein

Bezeichner auf Proteinebene für MRC2

mannose receptor, C type 2 , C-type mannose receptor 2 , C-type mannose receptor 2-like , collagen-binding factor Endo180 , endocytic receptor 180 , macrophage mannose receptor 2 , C-type lectin domain family 13 member E , UPAR-associated protein , endocytic receptor (macrophage mannose receptor family) , urokinase-type plasminogen activator receptor-associated protein , lectin lambda , novel lectin

GENE ID SPEZIES
454788 Pan troglodytes
529049 Bos taurus
100004793 Danio rerio
100036697 Xenopus (Silurana) tropicalis
100406333 Callithrix jacchus
100541638 Meleagris gallopavo
498011 Rattus norvegicus
9902 Homo sapiens
17534 Mus musculus
100688560 Canis lupus familiaris
100516106 Sus scrofa
419950 Gallus gallus
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