MAP/microtubule Affinity-Regulating Kinase 4 Proteine (MARK4)

MARK4 encodes a member of the microtubule affinity-regulating kinase family. Zusätzlich bieten wir Ihnen MARK4 Antikörper (128) und und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
MARK4 57787 Q96L34
MARK4 232944 Q8CIP4
Ratte MARK4 MARK4 680407  
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Showing 6 out of 6 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$13,984.89
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$13,984.89
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
Details
Insektenzellen Human GST tag 5 μg Anmelden zum Anzeigen 11 bis 12 Tage
$515.20
Details
Baculovirus infected Insect Cells Human GST tag   5 μg Anmelden zum Anzeigen 10 bis 12 Tage
$352.75
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Insektenzellen Human GST tag   10 μg Anmelden zum Anzeigen 3 bis 4 Tage
$310.00
Details

MARK4 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
,
Mouse (Murine)

Weitere Proteine zu MAP/microtubule Affinity-Regulating Kinase 4 (MARK4) Interaktionspartnern

Human MAP/microtubule Affinity-Regulating Kinase 4 (MARK4) Interaktionspartner

  1. data demonstrate that miR (zeige MLXIP Proteine)-515-5p dramatically inhibits cell migration by directly down-regulating MARK4 expression in two different cancer types

  2. Our results show that MARK4 acts as a negative regulator of the Hippo kinase cassette to promote YAP (zeige YAP1 Proteine)/TAZ (zeige TAZ Proteine) activity and that loss of MARK4 restrains the tumorigenic properties of breast cancer cells.

  3. Atypical PKC (zeige PRRT2 Proteine) phosphorylates serine-threonine residues of MARK4.

  4. Suggest role for polypyrimidine-tract binding protein (zeige PTBP1 Proteine) in regulating alternative splicing of MARK4 in gliomas.

  5. MARK4 is a key component in the regulation of microtubule dynamics and has major role in cell cycle progression, particularly at the G1/S transition.

  6. Molecular dynamic simulation data predicted the three dimensional structure for the kinase domain of MARK4 and its structural properties.

  7. A strong and significant elevation of MARK4 expression and MARK4-tau interactions in AD brains correlates with the Braak stages of the disease, suggesting that the MARK4-tau interactions are of functional importance in the progression of AD.

  8. MARK4 is a critical positive regulator of early steps in ciliogenesis.

  9. MARK4 is a new negative regulator of mTORC1

  10. The balance between the MARK4 isoforms is carefully guarded during neural differentiation but may be subverted in gliomagenesis.

Mouse (Murine) MAP/microtubule Affinity-Regulating Kinase 4 (MARK4) Interaktionspartner

  1. PPARgamma (zeige PPARG Proteine) interacted with Mark4 and inhibited the stimulating effect of Mark4 on oxidative stress and inflammation.

  2. MARK4 is a critical positive regulator of early steps in ciliogenesis.

  3. data indicate a key role of MARK4 in energy metabolism, implicating the kinase as a novel drug target for the treatment of obesity and type 2 diabetes.

  4. The balance between the MARK4 isoforms is carefully guarded during neural differentiation but may be subverted in gliomagenesis.

  5. MARK4 is a functional protein kinase (zeige CDK7 Proteine) which specifically phosphorylates a cognate peptide substrate for the AMP (zeige TMPRSS5 Proteine)-kinase family. On overexpression in heterologous cells functional wild-type protein, but not its kinase-dead mutant, decreased cell viability

MARK4 Protein Überblick

Protein Überblick

This gene encodes a member of the microtubule affinity-regulating kinase family. These protein kinases phosphorylate microtubule-associated proteins and regulate the transition between stable and dynamic microtubules. The encoded protein is associated with the centrosome throughout mitosis and may be involved in cell cycle control. Expression of this gene is a potential marker for cancer, and the encoded protein may also play a role in Alzheimer's disease. Pseudogenes of this gene are located on both the short and long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Genbezeichner und Symbole assoziert mit MARK4

  • microtubule affinity regulating kinase 4 (MARK4)
  • MAP/microtubule affinity regulating kinase 4 (Mark4)
  • microtubule affinity regulating kinase 4 (Mark4)
  • 2410090P21Rik Protein
  • C79806 Protein
  • MARK4 Protein
  • MARK4L Protein
  • MARK4S Protein
  • Markl1 Protein
  • MARKL1L Protein
  • PAR-1D Protein

Bezeichner auf Proteinebene für MARK4

MAP/microtubule affinity-regulating kinase 4 , MAP/microtubule affinity-regulating kinase like 1 , MARK4 serine/threonine protein kinase , MAP/microtubule affinity-regulating kinase 4L

GENE ID SPEZIES
100070770 Equus caballus
456123 Pan troglodytes
57787 Homo sapiens
232944 Mus musculus
680407 Rattus norvegicus
484449 Canis lupus familiaris
525675 Bos taurus
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