anti-MAD2L1 Binding Protein (MAD2L1BP) Antikörper

The protein encoded by MAD2L1BP was identified as a binding protein of the MAD2 mitotic arrest deficient-like 1 (MAD2/MAD2L1). Zusätzlich bieten wir Ihnen MAD2L1BP Proteine (9) und und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
MAD2L1BP 316237  
MAD2L1BP 9587 Q15013
MAD2L1BP 66591 Q9DCX1
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Top anti-MAD2L1BP Antikörper auf antikoerper-online.de

Showing 10 out of 74 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Hund Kaninchen Unkonjugiert WB 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Maus Unkonjugiert ELISA, IF, WB Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (55.88 KDa) . Dilution: 1:500~1000 MAD2L1BP monoclonal antibody (M03), clone 4G11. Western Blot analysis of MAD2L1BP expression in Hela S3 NE ( (# ABIN396419 ) Dilution: 1:500~1000 100 μg Anmelden zum Anzeigen 8 bis 11 Tage
$527.50
Details
Human Kaninchen Unkonjugiert WB Western blot analysis of MAD2L1BP expression in HEK293T (A), Raw264.7 (B), H9C2 (C) whole cell lysates. 200 μL Anmelden zum Anzeigen 13 bis 14 Tage
$487.50
Details
Human Kaninchen Unkonjugiert EIA, WB Western blot analysis of MAD2L1BP Antibody (N-term) in MCF-7 cell line lysates (35ug/lane). This demonstrates the MAD2L1BP antibody detected the MAD2L1BP protein (arrow). 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$484.00
Details
Human Kaninchen Unkonjugiert WB 100 μL Anmelden zum Anzeigen 11 bis 14 Tage
$507.83
Details
Human Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
$551.83
Details
Human Kaninchen Unkonjugiert ELISA, ICC, IF, WB Western blot analysis of extracts from K562 cells, using MAD2L1BP antibody. ABIN6275218 staining  Hela cells by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25¡ãC. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37¡ãC. An  Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody(Cat.# S0006), diluted at 1/600, was used as secondary antibod 100 μL Anmelden zum Anzeigen 11 bis 12 Tage
$390.77
Details
Human Kaninchen Unkonjugiert WB MAD2L1BP Antibody (N-term)  western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the MAD2L1BP antibody detected the MAD2L1BP protein (arrow). 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$385.00
Details
Human Maus Unkonjugiert IF, ELISA, WB MAD2L1BP monoclonal antibody (M03), clone 4G11. Western Blot analysis of MAD2L1BP expression in Hela S3 NE . Detection limit for recombinant GST tagged MAD2L1BP is 1 ng/ml as a capture antibody. 100 μg Anmelden zum Anzeigen 11 bis 12 Tage
$440.00
Details
Human Kaninchen Unkonjugiert ELISA, WB   100 μL Anmelden zum Anzeigen 16 Days
$181.73
Details

Weitere Antikörper gegen MAD2L1BP Interaktionspartner

Human MAD2L1 Binding Protein (MAD2L1BP) Interaktionspartner

  1. TRIP13-p31(comet) intercepts and disassembles free mitotic checkpoint complex not bound to anaphase-promoting complex/cyclosome through mediating the local unfolding of the Mad2 C-terminal region.

  2. MAD2-p31(comet) axis may serve as a potential therapeutic target for glioma.

  3. Thes authors show that p31(comet) binding to the TRIP13 N-terminal domain positions the disordered MAD2 N-terminus for engagement by the TRIP13 "pore loops", which then unfold MAD2 in the presence of ATP.

  4. p31comet-induced cell death is mediated by interactions with Mad2

  5. the oligomeric form of TRIP13 binds both p31(comet) and MCC

  6. joint action of TRIP13 and p31(comet) also promotes the release of Mad2 from MCC, participates in the complete disassembly of MCC and abrogates checkpoint inhibition of APC/C

  7. Altered p31(Comet):Mad2 expression ratios may provide new insight into altered spindle assembly checkpoint function and the generation of chromosomal instability in tumors.

  8. attenuating the affinity of p31(Comet) for Mad2 by phosphorylation promotes SAC activity in mitosis. Specifically, phosphorylation of Ser-102 weakens p31(Comet)-Mad2 binding and enhances p31(Comet)-mediated bypass of the SAC.

  9. study found p31(comet) traffics on and off kinetochores and also present in the cytosol; Cells depleted of p31(comet) arrest in metaphase with mature bipolar kinetochore-microtubule attachments; propose that p31(comet) is an essential component of machinery that silences the checkpoint during each cell cycle

  10. the importance of p31(comet) in checkpoint silencing and its potential as a target for antimitotic therapies.

  11. The binding of p31(comet) to Mad2 in mitotic checkpoint complex may trigger a conformational change in Cdc20 that facilitates its phosphorylation by Cdk, and that the latter process may promote its dissociation from BubR1.

  12. both p31(comet) and ubiquitination of Cdc20 are critical mechanisms of checkpoint inactivation. They act redundantly to promote Mad2 dissociation from Cdc20

  13. p31(comet) negatively regulates the spindle assembly checkpoint by extracting Mad2 from the MCC.

  14. This review presents knowledge of CMT2 and possible pathogenetic mechanisms responsible for the disease

  15. p31comet localizes to kinetochores in a C-Mad2-dependent manner. the Mad1:C-Mad2 complex undergoes regulation by p31comet-dependent 'capping'.

  16. Although p31(comet) binds to Mad2, it promotes the dissociation of Cdc20 from BubR1 in MCC.

  17. p31(comet, formerly known as Cmt2) counteracts the function of Mad2 and is required for the silencing of the spindle checkpoint

  18. p31(comet) does not have an impact on the formation of aneuploidy and tetraploidy found in human hepatocellular carcinoma.

  19. Data suggest that p31(comet)(CMT2) exploits the two-state behavior of Mad2 to block its activation by acting as an "anti-Mad2."

  20. p31(comet) induces tumor cell senescence by mediating p21(Waf1/Cip1) accumulation and Mad2 disruption and that these effects are dependent on a direct interaction of p31(comet) with Mad2.

Mouse (Murine) MAD2L1 Binding Protein (MAD2L1BP) Interaktionspartner

  1. p31comet-induced cell death is mediated by interactions with Mad2

MAD2L1BP Antigen-Profil

Protein Überblick

The protein encoded by this gene was identified as a binding protein of the MAD2 mitotic arrest deficient-like 1 (MAD2/MAD2L1). MAD2 is a key component of the spindle checkpoint that delays the onset of anaphase until all the kinetochores are attached to the spindle. This protein may interact with the spindle checkpoint and coordinate cell cycle events in late mitosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Genbezeichner und Symbole assoziert mit MAD2L1BP

  • MAD2L1 binding protein (Mad2l1bp) Antikörper
  • MAD2L1 binding protein (MAD2L1BP) Antikörper
  • 0610009D16Rik Antikörper
  • 2510031P20Rik Antikörper
  • AU018945 Antikörper
  • AW550977 Antikörper
  • C76045 Antikörper
  • CMT2 Antikörper
  • CMT2A Antikörper
  • CMT2B Antikörper
  • MAD2L1BP Antikörper
  • Mad2lbp Antikörper
  • mKIAA0110 Antikörper
  • RP1-261G23.6 Antikörper

Bezeichner auf Proteinebene für MAD2L1BP

MAD2L1-binding protein , MAD2L1 binding protein , caught by MAD2 protein

GENE ID SPEZIES
316237 Rattus norvegicus
421448 Gallus gallus
462721 Pan troglodytes
474916 Canis lupus familiaris
615542 Bos taurus
701099 Macaca mulatta
9587 Homo sapiens
66591 Mus musculus
Ausgewählte Anbieter für anti-MAD2L1BP (MAD2L1BP) Antikörper
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