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MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Zusätzlich bieten wir Ihnen MAD2L1 Antikörper (136) und viele weitere Produktgruppen zu diesem Protein an.
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These results identify an unexpected dependency on TRIP13 (zeige TRIP13 Proteine) in cells overexpressing Mad2.
this study shows that MAD2L1 is a prognostic biomarker for lung adenocarcinoma
MiR (zeige MLXIP Proteine)-200c-5p suppresses proliferation and metastasis of human hepatocellular carcinoma by suppressing MAD2L1 expression.
Low MAD2L1 expression is associated with Chromophobe Renal Cell Carcinomas.
TRAP1 (zeige TRAP1 Proteine) is relevant in the control of key cell cycle regulators in tumor cells. TRAP1 (zeige TRAP1 Proteine)/TBP7 (zeige PSMC4 Proteine) quality control of CDK1 (zeige CDK1 Proteine) and MAD2 contributes mechanistically to the regulation of mitotic entry and transit.
Thes authors show that p31 (zeige ATP6V1E1 Proteine)(comet) binding to the TRIP13 (zeige TRIP13 Proteine) N-terminal domain positions the disordered MAD2 N-terminus for engagement by the TRIP13 (zeige TRIP13 Proteine) "pore loops", which then unfold MAD2 in the presence of ATP.
catalytic activation of the spindle assembly checkpoint depends on regulated protein-protein interactions that accelerate the spontaneous but rate-limiting conversion of MAD2 required for mitotic checkpoint (zeige BUB3 Proteine) complex assembly
in addition to its role in checkpoint signaling, MAD2 ensures chromosome stability through the regulation of AURORA B (zeige AURKB Proteine).
Aberrant Mad2 expression was associated with cell proliferation and genetic instability, which may contribute to the carcinogenesis of PGI (zeige BGN Proteine)-DLBCL. Mad2 overexpression indicated a poor DFS (zeige FST Proteine).
interactions between Mad2 and H3K4 regulate resolution of the spindle assembly checkpoint by limiting closed Mad2 availability for Cdc20 (zeige CDC20 Proteine) inhibition.
Mad2 (zeige MXI1 Proteine)-positive tumors have a higher frequency of developing persistent subclones that avoid remission and continue to grow.
reduced MAD2 (zeige MXI1 Proteine) levels attenuate the apoptotic response to mis (zeige AMH Proteine)-segregating sex chromosomes and allow the formation of aneuploid sperm.
p31comet-induced cell death is mediated by interactions with Mad2 (zeige MXI1 Proteine)
study shows that Mad2 (zeige MXI1 Proteine) is a novel substrate for CCP6 (zeige AGBL4 Proteine) in megakaryocytes; Mad2 (zeige MXI1 Proteine) polyglutamylation plays a crucial role in the regulation of megakaryopoiesis
Exacerbating chromosome missegregation in CENP-E (zeige CENPE Proteine)+/- mice by reducing levels of another mitotic checkpoint component (zeige BUB3 Proteine), Mad2 (zeige MXI1 Proteine), results in elevated cell death and decreased tumor formation compared with reduction of either protein alone.
Mad2 (zeige MXI1 Proteine) is also repressed by p53 (zeige TP53 Proteine) and its upregulation is required for chromosome instability in a p53 (zeige TP53 Proteine) mutant tumor model
Data show that Mad2 (zeige MXI1 Proteine) haploinsufficiency is protective in the presence of a cycle-specific DNA synthesis agent in vivo, and Ape1/Ref-1 (zeige APEX1 Proteine) inhibitor in vitro.
Pcid2 (zeige PCID2 Proteine) is essential for B cell survival through the regulation of MAD2 (zeige MXI1 Proteine) expression during B cell differentiation
tumours that experience transient Mad2 (zeige MXI1 Proteine) overexpression and consequent chromosome instability recur at markedly elevated rates
a functional Mad2 (zeige MXI1 Proteine)-dependent spindle checkpoint exists during the first meiotic division in mammalian oocytes
MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is related to the MAD2L2 gene located on chromosome 1. A MAD2 pseudogene has been mapped to chromosome 14.
MAD2 (mitotic arrest deficient, yeast, homolog)-like 1
, MAD2-like protein 1
, mitotic arrest deficient 2-like protein 1
, mitotic arrest deficient, yeast, homolog-like 1
, mitotic spindle assembly checkpoint protein MAD2A
, MAD2 (mitotic arrest deficient, homolog)-like 1
, MAD2-like 1
, spindle assembly checkpoint protein Mad2
, MAD2 mitotic arrest deficient-like 1
, MAD2 mitotic arrest deficient-like 1 (yeast)