Leucine Carboxyl Methyltransferase 1 Proteine (LCMT1)

LCMT1 catalyzes the methylation of the carboxyl group of the C-terminal leucine residue (leu309) of the catalytic subunit of protein phosphatase-2A (PPP2CA\; MIM 176915) (De Baere et al., 1999 [PubMed 10600115]).[supplied by OMIM, Mar 2008]..

alle Proteine anzeigen Gen GeneID UniProt
Human LCMT1 LCMT1 51451 Q9UIC8
Maus LCMT1 LCMT1 30949  
Ratte LCMT1 LCMT1 361643 Q6P4Z6
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Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
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Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 15 bis 19 Tage
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
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Weitere Proteine zu Leucine Carboxyl Methyltransferase 1 (LCMT1) Interaktionspartnern

Human Leucine Carboxyl Methyltransferase 1 (LCMT1) Interaktionspartner

  1. We demonstrate that NNMT outcompetes leucine carboxyl methyl transferase 1 (LCMT1) for methyl transfer from principal methyl donor SAM in biological systems. Inhibiting NNMT increased the availability of methyl groups for LCMT1 to methylate PP2A, resulting in the inhibition of oncogenic serine/threonine kinases (STK).

  2. LCMT1-PME-1 (zeige PPME1 Proteine) methylation equilibrium is critical for regulating mitotic spindle size and thereby proper cell division

  3. alterations in the membrane localization of PP2A (zeige PPP2R4 Proteine) and Tau following down-regulation of LCMT1 may lead to PP2A (zeige PPP2R4 Proteine) and Tau dysfunction in AD.

  4. Data indicate that PP2A (zeige PPP2R4 Proteine) holoenzyme biogenesis and activity are controlled by five PP2A (zeige PPP2R4 Proteine) modulators, consisting of alpha4, PTPA (zeige PPP2R4 Proteine), LCMT1, PME-1 (zeige PPME1 Proteine) and TIPRL1, which serve to prevent promiscuous phosphatase activity until the holoenzyme is completely assembled.

  5. GSK-3beta can inhibit PP2A (zeige PPP2R4 Proteine) by increasing the inhibitory L309-demethylation involving upregulation of PME-1 (zeige PPME1 Proteine) and inhibition of PPMT1

  6. determined crystal structures of human LCMT-1 in isolation and in complex with PP2A (zeige PPP2R4 Proteine) stabilized by a cofactor mimic. The structures show that the LCMT-1 active-site pocket recognizes the carboxyl terminus of PP2A (zeige PPP2R4 Proteine)

  7. X-ray crystal structure of human LCMT1 protein in complex with the cofactor S-adenosylmethionine (AdoMet (zeige MAT1A Proteine)) has been solved to a resolution of 2 A.

  8. LCMT-1 is important for normal progression through mitosis and cell survival and is essential for embryonic development

Mouse (Murine) Leucine Carboxyl Methyltransferase 1 (LCMT1) Interaktionspartner

  1. LCMT-1 homozygous knock-out MEFs exhibited hyperphosphorylation of HDAC3 (zeige HDAC3 Proteine), a reported target of the methylation-dependent PP4R1 (zeige PPP4R1 Proteine)-PP4c (zeige PPP4C Proteine) complex. Collectively, our data suggest that LCMT-1 coordinately regulates the carboxyl methylation of PP2A (zeige PPP2R2B Proteine)-related phosphatases and, consequently, their holoenzyme assembly and function.

  2. In LCMT1 deficiency enzyme activity and methylation of PP2A (zeige PPP2R2B Proteine) are reduced in a coordinate fashion, suggesting that LCMT1 is the only PP2A (zeige PPP2R2B Proteine) methyltransferase.

  3. Enhanced expression of LCMT1 in cultured neuroblastoma cells, which increases endogenous methylated catalytic C subunit and Balpha levels, induces changes in F-actin organization.

  4. LCMT-1 is important for normal progression through mitosis and cell survival and is essential for embryonic development

Leucine Carboxyl Methyltransferase 1 (LCMT1) Protein Überblick

Protein Überblick

LCMT1 catalyzes the methylation of the carboxyl group of the C-terminal leucine residue (leu309) of the catalytic subunit of protein phosphatase-2A (PPP2CA\; MIM 176915) (De Baere et al., 1999

Genbezeichner und Symbole assoziert mit LCMT1

  • leucine carboxyl methyltransferase 1 (LCMT1)
  • leucine carboxyl methyltransferase 1 (lcmt1)
  • leucine carboxyl methyltransferase 1 L homeolog (lcmt1.L)
  • leucine carboxyl methyltransferase 1 (ANI_1_2090074)
  • leucine carboxyl methyltransferase 1 (PTRG_02142)
  • leucine carboxyl methyltransferase 1 (MCYG_00360)
  • leucine carboxyl methyltransferase 1 (AOR_1_842194)
  • leucine carboxyl methyltransferase 1 (Tsp_08223)
  • leucine carboxyl methyltransferase 1 (Lcmt1)
  • AL033290 Protein
  • Lcmt Protein
  • LCMT-1 Protein
  • MGC114784 Protein
  • PPMT1 Protein
  • zgc:101094 Protein

Bezeichner auf Proteinebene für LCMT1

leucine carboxyl methyltransferase 1 , [Phosphatase 2A protein]-leucine-carboxy methyltransferase 1 , protein phosphatase methyltransferase 1 , protein-leucine O-methyltransferase

GENE ID SPEZIES
416565 Gallus gallus
447907 Danio rerio
467930 Pan troglodytes
548787 Xenopus (Silurana) tropicalis
608360 Canis lupus familiaris
734508 Xenopus laevis
4983025 Aspergillus niger CBS 513.88
6338383 Pyrenophora tritici-repentis Pt-1C-BFP
9225317 Arthroderma otae CBS 113480
10099666 Aspergillus oryzae RIB40
10906787 Trichinella spiralis
100196453 Salmo salar
100528205 Ictalurus punctatus
100606762 Nomascus leucogenys
51451 Homo sapiens
30949 Mus musculus
361643 Rattus norvegicus
618021 Bos taurus
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