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BAT3 was first characterized as part of a cluster of genes located within the human major histocompatibility complex class III region.
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Human Polyclonal BAT3 Primary Antibody für ELISA, IHC - ABIN451797
Annunziata, Kleinberg, Davidson, Berner, Gius, Tchabo, Steinberg, Kohn: BAG-4/SODD and associated antiapoptotic proteins are linked to aggressiveness of epithelial ovarian cancer. in Clinical cancer research : an official journal of the American Association for Cancer Research 2007
Arabidopsis BAG6 (AtBAG6) knockout lines exhibited a pronounced enhancement of susceptibility to the necrotrophic fungal pathogen Botrytis cinerea.
Targeted inactivation of BAGP1 or APCB1 results in the blocking of BAG6 processing and loss of fungal resistance.
BAT3 negatively regulates lipopolysaccharide-induced NF-kappaB (zeige NFKB1 Antikörper) signaling through TRAF6 (zeige TRAF6 Antikörper).
The observations suggest a mechanism whereby the BAG6 ubiquitin-linked domain provides a platform for discriminating substrates with shorter hydrophobicity stretches as a signal for defective proteins.
we found BAG6 to be dispensable in antigen processing
Data indicate that the BAGS domain of BAG6 (Bcl-2-associated athanogene 6) interacts with the C-terminal domain of Ubl4a (ubiquitin-like protein 4a (zeige UBL4A Antikörper)).
BAG6 also decreases the EP300 (zeige EP300 Antikörper) dependent-acetylation of ATG5 (zeige ATG5 Antikörper), ATG7 (zeige ATG7 Antikörper), and LC3 (zeige MAP1LC3A Antikörper)-I, posttranslational modifications that inhibit autophagy.
BAT3 tightly controls autophagy by modulating p300 (zeige NOTCH1 Antikörper) intracellular localization, affecting the accessibility of p300 (zeige NOTCH1 Antikörper) to its substrates, p53 (zeige TP53 Antikörper) and ATG7 (zeige ATG7 Antikörper).
Mycobacterium tuberculosis-derived protein ESAT-6 (Rv3875) induced transient increase in the expression and release of BAT3 in macrophages.
Bat3 interacts with the nuclear phosphatase small C-terminal domain phosphatase (SCP) 2 (zeige CRISP3 Antikörper), which terminates BMP signaling by dephosphorylating Smad1 (zeige SMAD1 Antikörper)/5/8.
Scythe is critical for viability and normal development, probably via regulation of programmed cell death and cellular proliferation
Scythe regulates apoptosis-inducing factor (zeige AIFM1 Antikörper) stability during endoplasmic reticulum stress-induced apoptosis
BAG6 co-localizes with HSPA2 (zeige HSPA2 Antikörper) in huinan testicular germ cells and epididymal spermatozoa, moving from the equator to the anterior head during capacitation and stably interacting with HSPA2 (zeige HSPA2 Antikörper). In zona pellucida binding defect infertility, BAG6 is lacking.
VNTR in the coding region of the FAM46A gene, FAM46A rs11040 SNP and BAG6 rs3117582 SNP are associated with susceptibility to tuberculosis
BAG6 rs3117582 SNP was associated with non small cell lung cancer in the Norwegian subjects and the combined Croatian-Norwegian subjects corroborating the earlier finding that BAG6 rs3117582 SNP was associated with lung cancer in Europeans.
The BAT2 (zeige BAT2 Antikörper)/BAT3 polymorphisms and specifically the A/C haplotype may represent a novel immunogenetic factor associated with graft rejection in patients undergoing allo-HSCT.
Data show that molecular chaperone (zeige HSP90AA1 Antikörper) BAG6_ubiquitin-like domain (UBL) and ubiquitin-like 4A (zeige UBL4A Antikörper) UBL4A_UBL compete for the same binding site on N-terminal dimerisation domain of SGTA (zeige SGTA Antikörper) protein (SGTA_NT).
This meta-analysis suggested that HLA-B-associated transcript 3 polymorphisms are risk factors for lung cancer.
Both TRC35 (zeige C7orf20 Antikörper) and Ubl4A (zeige UBL4A Antikörper) have distinct C-terminal binding sites on Bag6 defining a minimal Bag6 complex.
Exogenous BAG6 perturbs the function of the BAG6 complex at a stage subsequent to substrate recognition and polyubiquitylation, most likely the BAG6-dependent delivery of OpD (zeige FLNA Antikörper) to the proteasome.
This gene was first characterized as part of a cluster of genes located within the human major histocompatibility complex class III region. This gene encodes a nuclear protein that is cleaved by caspase 3 and is implicated in the control of apoptosis. In addition, the protein forms a complex with E1A binding protein p300 and is required for the acetylation of p53 in response to DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene.
BAG family molecular chaperone regulator 6
, HLA-B-associated transcript 3
, large proline-rich protein BAG6
, large proline-rich protein BAT3
, protein Scythe
, HLA-B associated transcript 3
, HLA-B associated transcript-3
, protein G3
, Large proline-rich protein BAT3