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Regulates the coordinated translation of type I collagen alpha-1 and alpha-2 mRNAs, CO1A1 and CO1A2.
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A cytoplasmic isoform of La protein as well as LARPs 6, 4, and 1 function in mRNA metabolism and translation in distinct but similar ways, sometimes with the poly(A)-binding protein, and in some cases by direct binding to poly(A)-RNA.
Akt (zeige AKT1 Proteine) mediated phosphorylation of LARP6; critical step in biosynthesis of type I collagen
We postulate that collagen mRNAs directly partition to the endoplasmic reticulum membrane prior to synthesis of the signal peptide and that LARP6 and nonmuscle myosin filaments mediate this process.
Data indicate that LA motif protein LARP6 binding to spliced leader RNA (5'SL) of collagen alpha2(I) mRNA is more stable than the binding to 5'SL of alpha1(I) mRNA.
The study presents the structure of the La motif and RRM1 (zeige RRM1 Proteine) of human LARP6 uncovering in both cases considerable structural variation in comparison to the equivalent domains in La and revealing an unprecedented fold for the RRM1 (zeige RRM1 Proteine).
LARP6 is a critical mediator by which IGF-1 (zeige IGF1 Proteine) augments synthesis of collagen type I in vascular smooth muscle
The results demonstrate that the La modules of the human LARP6 is also active in tRNA-mediated suppression, even in the absence of stable UUU-3'OH trailer protection.
Acheron regulates vascular endothelial proliferation and angiogenesis together with Id1 (zeige ID1 Proteine) during wound healing.
Achn enhances human breast tumor growth and vascularization and that this activity is dependent on nuclear localization.
LARP6 has a distinctive bipartite RNA binding domain not found in other members of the La superfamily. LARP6 interacts with the two single-stranded regions of the 5' stem-loop.
Data indicate that insulin-like growth factor 1 (IGF1 (zeige IGF1 Proteine)) could promote collagen I alpha 2 (COL1A2 (zeige COL1A2 Proteine)) expression and osteoblast differentiation in primary pre-osteoblasts by increasing La ribonucleoprotein domain family member 6 (Larp6) expression via a posttranscriptional mechanism.
These data define Achn as a newly discovered regulatory molecule that presumably mediates a variety of developmental and homeostatic processes in animals.
achn plays key roles in the processes of differentiation and self-renewal
Regulates the coordinated translation of type I collagen alpha-1 and alpha-2 mRNAs, CO1A1 and CO1A2. Stabilizes mRNAs through high-affinity binding of a stem-loop structure in their 5' UTR. This regulation requires VIM and MYH10 filaments, and the helicase DHX9 (By similarity).
La ribonucleoprotein domain family, member 6
, death-associated LA motif protein
, la-related protein 6