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Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. Zusätzlich bieten wir Ihnen Isocitrate Dehydrogenase 3 (NAD+) gamma Antikörper (75) und und viele weitere Produktgruppen zu diesem Protein an.
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active sites of the human NAD-IDH are shared between alpha and gamma subunits and between alpha and beta subunits
Aspartate-190 is a determinant of IDH gamma subunit affinity for the manganese (MnII) ion, as well as for nicotinamide-adenine dinucleotide (NAD), but is not directly required for the catalytic reaction.
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the gamma subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. This gene is a candidate gene for periventricular heterotopia. Several alternatively spliced transcript variants of this gene have been described, but only some of their full length natures have been determined.
, NAD (H)-specific isocitrate dehydrogenase gamma subunit
, NAD(+)-specific ICDH subunit gamma
, NAD+-specific ICDH
, isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial
, isocitrate dehydrogenase, NAD(+)-specific, mitochondrial, gamma subunit
, isocitric dehydrogenase subunit gamma
, isocitrate dehydrogenase 3 (NAD+) gamma
, isocitrate dehydrogenase 3 gamma
, isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial-like
, isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial
, NAD+-isocitrate dehydrogenase gamma subunit
, isocitrate dehydrogenase 3, gamma