Interleukin 4 Induced 1 Proteine (IL4I1)

Mouse (Murine) Interleukin 4 Induced 1 (IL4I1) Interaktionspartner

1. IL4I1 negatively controls B-Cell Antigen Receptor-dependent B cell activation.

2. The H46 locus on chromosome 7 was found to encode the interleukin 4-induced IL4i1 gene.

3. IL4I1 promotes central nervous system remyelination and axonal integrity.

4. our findings indicate that IL4I1 promotes an enhanced M2 functional phenotype.

5. inhibits CD8+ antitumor T-cell response in vivo

Human Interleukin 4 Induced 1 (IL4I1) Interaktionspartner

1. the presence of IL4I1 during T-cell activation decreases early signaling events downstream of t-cell receptor stimulation, resulting in global T-cell inhibition which is more pronounced when there is CD28 costimulation.

2. Data showed proteome changes in alveolar epithelial cells type II exposed to an infection with A. fumigatus with IL4I1 showing the most prominent increase in abundance both, in terms of relative abundance as well as activity. Also, in the infected lungs, there was levels of IL4I1 metabolic products.

3. reviewed SNPs of the IL4I1 isoform 1, which is expressed in lymphoid tissue; the N92D SNP leads to a hyperactive enzyme, while the R102G mutation is hypomorphic; show that IL4I1 activity is not only directed against phenylalanine, as initially described, but also at a lower level against arginine

4. The immunosuppressive enzyme IL4I1 expressed differentially in human induced Aiolos+, but not natural Helios+, FOXP3+ Treg cells.

5. IL4I1 upregulation in human Th17 cells limits their TCR-mediated expansion not only by blocking the molecular pathway involved in the activation of the IL-2 promoter, but also by maintaining high levels of Tob1, which impairs entry into the cell cycle.

6. IL4I1 plays a distinct role compared to other antibacterial enzymes produced by mononuclear phagocytes.

7. participates in the downregulation of Th1 inflammation

8. genomic structure, cDNA sequence, chromosome location and RNA expression in immune tissues

9. is activated in primary mediastinal large B-cell lymphoma, which might be due to a constitutive activation of a cytokine signaling pathway

10. hIL4I1 inhibited the proliferation of CD3-stimulated T lymphocytes with a similar effect on CD4(+) and CD8(+) T cells. In contrast, memory T cells were more strongly affected by hIL4I1 and its catabolite H(2)O(2) than naive T cells

11. strong IL4I1 expression is associated with B-cell lymphomas.