Integrin, alpha E (Antigen CD103, Human Mucosal Lymphocyte Antigen 1, alpha Polypeptide) Proteine (ITGAE)

Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Zusätzlich bieten wir Ihnen ITGAE Antikörper (351) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
ITGAE 16407 Q60677
Ratte ITGAE ITGAE 83577  
ITGAE 3682 P38570
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Showing 5 out of 12 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 50 bis 55 Tage
$5,262.31
Details
Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 50 bis 55 Tage
$7,493.38
Details
Escherichia coli (E. coli) Maus His tag,T7 tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$704.00
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$814.00
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
Details

ITGAE Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine) ,
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Human , ,
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Weitere Proteine zu Integrin, alpha E (Antigen CD103, Human Mucosal Lymphocyte Antigen 1, alpha Polypeptide) (ITGAE) Interaktionspartnern

Mouse (Murine) Integrin, alpha E (Antigen CD103, Human Mucosal Lymphocyte Antigen 1, alpha Polypeptide) (ITGAE) Interaktionspartner

  1. The adoptive transfer of CD103(+) cDC1s to Batf3 deficient animals reversed these observed changes and more importantly could attenuate cellular damage and inflammation in established steatohepatitis.

  2. AEbeta7 is of key relevance for gut trafficking of inflammatory bowel disease (IBD) CD8(+) T cells and CD4(+) Th9 cells in vivo and mainly retention might account for this effect. These findings indicate that blockade of alphaEbeta7 in addition to alpha4beta7 may be particularly effective in intestinal disorders with expansion of CD8(+) and Th9 cells such as IBD.

  3. Mesenteric lymph node CD11b(-) CD103(+) PD-L1(High) dendritic cell subset probably takes up luminal antigens in the intestine, migrates to MLNs, and highly induces regulatory T cells through TGF-beta activation.

  4. NR4A3 plays an important role in the regulation of CD103+ mDCs by regulating CCR7-dependent cell migration.

  5. Oral treatment with the mucosal adjuvant cholera toxin (CT) induces expression of T cell immunoglobulin and mucin domain containing 4 (TIM-4) on a proportion of CD103+ CD11b+ dendritic cell (DC) in the intestinal lamina propria (LP).

  6. while alphaE (CD103) expression is indeed associated with hTGFbeta1 in vivo, it has little, if any, influence on the course of the psoriasis-like phenotype in K5.hTGFbeta1 transgenic mice

  7. Intestinal CD103(+)CD11b(-) dendritic cells restrain colitis via IFN-gamma-induced anti-inflammatory response in epithelial cells.

  8. Antigen-specific cytotoxic T lymphocytes target airway CD103+ and CD11b+ dendritic cells to suppress allergic inflammation.

  9. CD103 on FoxP3+ Treg cells was involved in Treg retention to inflamed skin.

  10. Interleukin-12-producing CD103+ CD11b- CD8+ dendritic cells are responsible for eliciting gut intraepithelial lymphocyte response against Encephalitozoon cuniculi.

  11. An important role for CD103 in the control of airway inflammation in asthma.

  12. Donor colonic CD103+ dendritic cells determine the severity of acute graft-versus-host disease.

  13. CXCR3-dependent recruitment of cells to inflamed areas was critical for development of the CD8-positive, CD103-negative T lymphocyte population and pathogen clearance.

  14. CD11c(+) CD103(+) cells of Mycobacterium tuberculosis-infected C57BL/6 but not of BALB/c mice induce a high frequency of interferon-gamma- or interleukin-17-producing CD4(+) cells.

  15. ITGAE(+) cells play a key role in the development of autoimmune diabetes; this is consistent with the hypothesis that ITGAE(+)CD8(+)T effectors initiate the disease process.

  16. IL-2Rbeta-dependent signaling and CD103 functionally cooperate to maintain tolerance in the gut mucosa.

  17. IL-12 production by Batf3-dependent CD103+ dendritic cells is crucial for maintenance of local Th1 immunity against L. major infection.

  18. CD103-CD11b+ dendritic cells regulate the sensitivity of CD4 T-cell responses to bacterial flagellin.

  19. Data indicate that CD103(+)CD8(+) T(RM) cells developed in the skin from epithelium-infiltrating precursor cells that lacked expression of the effector-cell marker KLRG1.

  20. De novo Foxp3 expression in CD4+ T cells depends on CD103+ dendritic cell(DC)s and not plasmacytoid DCs to promote airway tolerance.

Human Integrin, alpha E (Antigen CD103, Human Mucosal Lymphocyte Antigen 1, alpha Polypeptide) (ITGAE) Interaktionspartner

  1. Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors.

  2. Pxn binding to the CD103 cytoplasmic tail triggers alphaEbeta7 integrin outside-in signaling that promotes CD8(+) T-cell migratory behavior and effector functions.

  3. AEbeta7 is of key relevance for gut trafficking of inflammatory bowel disease (IBD) CD8(+) T cells and CD4(+) Th9 cells in vivo and mainly retention might account for this effect. These findings indicate that blockade of alphaEbeta7 in addition to alpha4beta7 may be particularly effective in intestinal disorders with expansion of CD8(+) and Th9 cells such as IBD.

  4. The CD103+CD4+/CD4+ ratio does not accurately discriminate between sarcoidosis and other causes of lymphocytic alveolitis, neither alone nor in combination with the CD4+/CD8+ ratio, and is not a powerful marker for the diagnosis of sarcoidosis.

  5. CD103 expression in human dendritic cells is regulated differentially by retinoic acid and Toll-like receptor ligands.

  6. detected CD103 tumor cells in 41% (16/39) of lymph node-involved adult T-cell leukemia/lymphoma

  7. Levels of GZMA and ITGAE mRNAs in colon tissues can identify patients with UC who are most likely to benefit from etrolizumab; expression levels decrease with etrolizumab administration in biomarker(high) patients.

  8. PD-1(+)CD103(+) CD8 TIL might regain functional antitumor activity, an effect that potentially could be augmented by immune modulation.

  9. This report highlights the diagnostic difficulties and the need of consensus in categorizing clonal CD103(+) lymphocytosis in patients with refractory celiac disease.

  10. Cell-sorting experiments demonstrated that IDO1 expression is found in a subset of CD1a(+)CD14(-)langerin(+) cells, expressing CD103

  11. Report CD103 expression occurs most frequently in gastrointestinal T-cell lymphomas.

  12. Tumor-infiltrating lymphocytes expressing the tissue resident memory marker CD103 are associated with increased survival in high-grade serous ovarian cancer.

  13. Using a human CTL system model based on a CD8(+)/CD103(-) T cell clone specific of a lung tumor-associated Ag, we demonstrated that the transcription factors Smad2/3 and NFAT-1 are two critical regulators of this process.

  14. Memory CD103+ CD8 T cells that persist within the brain after an acute infection with vesicular stomatitis virus are bona fide tissue resident memory cells.

  15. Lymphoid tissue (LT)-resident CD8alpha-positive dendritic cells (DCs) and non(LT)-derived CD103-positive DCs express transgenic XCR1 and are characterized by a unique transcriptional fingerprint, irrespective of their tissue of origin.

  16. These findings support the usefulness of CD123 and CD103 to aid in the differential diagnosis of B-cell lymphoproliferative disorders

  17. Studies indicate that the mechanisms that regulate the retention of tissue-resident memory T cells include TGF-beta-mediated induction of CD103 and downregulation of CCR7.

  18. results show that binding of the human alphaE I domain to oral and skin keratinocytes is independent of E-cadherin

  19. has a role in mucosal immunity and graft rejection

  20. Involvement of the adhesive ligand pair CD103-E-cadherin in human thymocyte cell proliferation

ITGAE Protein Überblick

Protein Überblick

Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation.

Genbezeichner und Symbole assoziert mit ITGAE

  • integrin alpha E, epithelial-associated (Itgae)
  • integrin subunit alpha E (Itgae)
  • integrin subunit alpha E (ITGAE)
  • A530055J10 Protein
  • alpha-E1 Protein
  • alpha-M290 Protein
  • aM290 Protein
  • CD103 Protein
  • HUMINAE Protein

Bezeichner auf Proteinebene für ITGAE

integrin alpha M290 , integrin alpha-E , integrin alpha E1, epithelial-associated , integrin, alpha E, epithelial-associated , HML-1 antigen , antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide , integrin alpha-IEL , mucosal lymphocyte 1 antigen

GENE ID SPEZIES
16407 Mus musculus
83577 Rattus norvegicus
3682 Homo sapiens
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