Integrin, alpha E (Antigen CD103, Human Mucosal Lymphocyte Antigen 1, alpha Polypeptide) Proteine (ITGAE)

Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Zusätzlich bieten wir Ihnen ITGAE Antikörper (361) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
ITGAE 16407 Q60677
Ratte ITGAE ITGAE 83577  
ITGAE 3682 P38570
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Showing 5 out of 12 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 50 bis 55 Tage
$5,355.45
Details
Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 50 bis 55 Tage
$7,626.01
Details
Escherichia coli (E. coli) Maus His tag,T7 tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$704.00
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$814.00
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
Details

ITGAE Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine) ,
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Human , ,
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Weitere Proteine zu Integrin, alpha E (Antigen CD103, Human Mucosal Lymphocyte Antigen 1, alpha Polypeptide) (ITGAE) Interaktionspartnern

Mouse (Murine) Integrin, alpha E (Antigen CD103, Human Mucosal Lymphocyte Antigen 1, alpha Polypeptide) (ITGAE) Interaktionspartner

  1. The adoptive transfer of CD103(+) cDC1s to Batf3 (zeige BATF3 Proteine) deficient animals reversed these observed changes and more importantly could attenuate cellular damage and inflammation in established steatohepatitis.

  2. AEbeta7 is of key relevance for gut trafficking of inflammatory bowel disease (IBD) CD8(+) T cells and CD4(+) Th9 cells in vivo and mainly retention might account for this effect. These findings indicate that blockade of alphaEbeta7 in addition to alpha4beta7 may be particularly effective in intestinal disorders with expansion of CD8(+) and Th9 cells such as IBD.

  3. Mesenteric lymph node CD11b (zeige ITGAM Proteine)(-) CD103(+) PD-L1 (zeige CD274 Proteine)(High) dendritic cell subset probably takes up luminal antigens in the intestine, migrates to MLNs, and highly induces regulatory T cells through TGF-beta (zeige TGFB1 Proteine) activation.

  4. NR4A3 (zeige NR4A3 Proteine) plays an important role in the regulation of CD103+ mDCs by regulating CCR7 (zeige CCR7 Proteine)-dependent cell migration.

  5. Oral treatment with the mucosal adjuvant cholera toxin (CT) induces expression of T cell immunoglobulin and mucin domain containing 4 (TIM-4 (zeige TIMD4 Proteine)) on a proportion of CD103+ CD11b (zeige ITGAM Proteine)+ dendritic cell (DC) in the intestinal lamina propria (LP).

  6. while alphaE (CD103) expression is indeed associated with hTGFbeta1 in vivo, it has little, if any, influence on the course of the psoriasis-like phenotype in K5.hTGFbeta1 transgenic mice

  7. Intestinal CD103(+)CD11b (zeige ITGAM Proteine)(-) dendritic cells restrain colitis via IFN-gamma-induced (zeige SAMHD1 Proteine) anti-inflammatory response in epithelial cells.

  8. Antigen-specific cytotoxic T lymphocytes target airway CD103+ and CD11b (zeige ITGAM Proteine)+ dendritic cells to suppress allergic inflammation.

  9. CD103 on FoxP3 (zeige FOXP3 Proteine)+ Treg cells was involved in Treg retention to inflamed skin.

  10. Interleukin-12-producing CD103+ CD11b (zeige ITGAM Proteine)- CD8 (zeige CD8A Proteine)+ dendritic cells are responsible for eliciting gut (zeige GUSB Proteine) intraepithelial lymphocyte response against Encephalitozoon cuniculi.

Human Integrin, alpha E (Antigen CD103, Human Mucosal Lymphocyte Antigen 1, alpha Polypeptide) (ITGAE) Interaktionspartner

  1. Pxn (zeige PXN Proteine) binding to the CD103 cytoplasmic tail triggers alphaEbeta7 integrin outside-in signaling that promotes CD8 (zeige CD8A Proteine)(+) T-cell migratory behavior and effector functions.

  2. AEbeta7 is of key relevance for gut trafficking of inflammatory bowel disease (IBD) CD8(+) T cells and CD4(+) Th9 cells in vivo and mainly retention might account for this effect. These findings indicate that blockade of alphaEbeta7 in addition to alpha4beta7 may be particularly effective in intestinal disorders with expansion of CD8(+) and Th9 cells such as IBD.

  3. The CD103+CD4+/CD4 (zeige CD4 Proteine)+ ratio does not accurately discriminate between sarcoidosis and other causes of lymphocytic alveolitis, neither alone nor in combination with the CD4 (zeige CD4 Proteine)+/CD8 (zeige CD8A Proteine)+ ratio, and is not a powerful marker for the diagnosis of sarcoidosis.

  4. CD103 expression in human dendritic cells is regulated differentially by retinoic acid and Toll (zeige TLR4 Proteine)-like receptor ligands.

  5. detected CD103 tumor cells in 41% (16/39) of lymph node-involved adult T-cell leukemia/lymphoma

  6. Levels of GZMA (zeige GZMA Proteine) and ITGAE mRNAs in colon tissues can identify patients with UC who are most likely to benefit from etrolizumab; expression levels decrease with etrolizumab administration in biomarker(high) patients.

  7. PD-1 (zeige PDCD1 Proteine)(+)CD103(+) CD8 (zeige CD8A Proteine) TIL (zeige TLR1 Proteine) might regain functional antitumor activity, an effect that potentially could be augmented by immune modulation.

  8. This report highlights the diagnostic difficulties and the need of consensus in categorizing clonal CD103(+) lymphocytosis in patients with refractory celiac disease.

  9. Cell-sorting experiments demonstrated that IDO1 (zeige IDO1 Proteine) expression is found in a subset of CD1a (zeige CD1A Proteine)(+)CD14 (zeige NDUFA2 Proteine)(-)langerin (zeige CD207 Proteine)(+) cells, expressing CD103

  10. Report CD103 expression occurs most frequently in gastrointestinal T-cell lymphomas.

ITGAE Protein Überblick

Protein Überblick

Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation.

Genbezeichner und Symbole assoziert mit ITGAE

  • integrin alpha E, epithelial-associated (Itgae)
  • integrin subunit alpha E (Itgae)
  • integrin subunit alpha E (ITGAE)
  • A530055J10 Protein
  • alpha-E1 Protein
  • alpha-M290 Protein
  • aM290 Protein
  • CD103 Protein
  • HUMINAE Protein

Bezeichner auf Proteinebene für ITGAE

integrin alpha M290 , integrin alpha-E , integrin alpha E1, epithelial-associated , integrin, alpha E, epithelial-associated , HML-1 antigen , antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide , integrin alpha-IEL , mucosal lymphocyte 1 antigen

GENE ID SPEZIES
16407 Mus musculus
83577 Rattus norvegicus
3682 Homo sapiens
Ausgewählte Anbieter für ITGAE Proteine (ITGAE)
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