Hypoxia Inducible Factor 3, alpha Subunit Proteine (HIF3A)

The protein encoded by HIF3A is the alpha-3 subunit of one of several alpha/beta-subunit heterodimeric transcription factors that regulate many adaptive responses to low oxygen tension (hypoxia). Zusätzlich bieten wir Ihnen HIF3A Antikörper (88) und HIF3A Kits (5) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
HIF3A 64344 Q9Y2N7
HIF3A 53417 Q0VBL6
HIF3A 64345 Q9JHS2
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Showing 4 out of 4 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$8,498.50
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Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$8,498.50
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,921.50
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HIF3A Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
,
Mouse (Murine)

Rat (Rattus)

Weitere Proteine zu Hypoxia Inducible Factor 3, alpha Subunit (HIF3A) Interaktionspartnern

Human Hypoxia Inducible Factor 3, alpha Subunit (HIF3A) Interaktionspartner

  1. NAP peptide prevents outer blood retinal barrier breakdown by reducing HIF1alpha (zeige HIF1A Proteine)/HIF2alpha (zeige EPAS1 Proteine), VEGF (zeige VEGFA Proteine)/VEGFRs, and increasing HIF3alpha expression Moreover it is able to reduce the percentage of apoptotic cells by modulating the expression of two death related genes, BAX (zeige BAX Proteine) and Bcl2 (zeige BCL2 Proteine).

  2. HIF3A methylation was found in the association between the HIF3A rs3826795 polymorphism and alanine aminotransferase (zeige ALT Proteine) among obese children.

  3. TIMP2 (zeige TIMP2 Proteine) suppression, in a hypoxic environment, was induced through a regulatory feedback circuit consisting of hypoxia-inducible factor (HIF) 1 alpha (zeige HIF1A Proteine), microRNA-210 (miR (zeige MLXIP Proteine)-210), and HIF-3alpha.

  4. Results were discordant with those expected if HIF3A methylation has a causal effect on body mass index (BMI) & provided more evidence for causality in the reverse direction (i.e., an effect of BMI on HIF3A methylation); results also show a long-lasting intergenerational influence of maternal BMI on offspring methylation at this locus, which may confound associations between own adiposity & HIF3A methylation.

  5. DNA methylation (zeige HELLS Proteine) in HIF3A shares moderate correlation between adipose tissue and blood, and both are associated with BMI. In contrast, methylation in FASN (zeige FASN Proteine) is poorly correlated across tissues, but the DNA methylation (zeige HELLS Proteine) in adipose tissue but not blood is highly associated with BMI

  6. Reduced lifetimes of the donor were partially restored by coexpression of HIF-1alpha (zeige HIF1A Proteine) or Bcl-xL (zeige BCL2L1 Proteine), binding proteins of IPAS in the nucleus and mitochondria, respectively.

  7. Results confirmed a positive association between BMI and HIF3A DNA promoter methylation in the blood. The tissue-specific results of HIF3A gene expression indicate that subcutaneous adipose tissue is the more functional tissue in which a low expression may adversely affect whole-body insulin (zeige INS Proteine) sensitivity.

  8. Parkin (zeige PARK2 Proteine) is downregulated under hypoxia and that it interferes with HIF expression based on cellular oxygen tension.

  9. This provides a compelling model for how hypoxia-induced miR (zeige MLXIP Proteine)-429 regulates the switch between HIF-1 (zeige HIF1A Proteine) adaptive responses to HIF-3 survival responses by rapidly decreasing HIF1A (zeige HIF1A Proteine) levels while simultaneously slowing the progression of HIF3A expression until the miR (zeige MLXIP Proteine)-429 levels drop below normoxic levels.

  10. The association between increased DNA methylation (zeige HELLS Proteine) at HIF3A and increased adiposity is present in neonates.

Mouse (Murine) Hypoxia Inducible Factor 3, alpha Subunit (HIF3A) Interaktionspartner

  1. Phosphorylation of inhibitory PAS domain protein (IPAS) at Ser184 by MAPK-activated protein kinase 2 (MK2 (zeige MAPKAPK2 Proteine) or MAPKAPK2 (zeige MAPKAPK2 Proteine)) enhances the proapoptotic function of IPAS.

  2. Report suggests that BV-2 microglial cells express HIF-3a under inflammatory conditions and that its activation differed from that of HIF-1a (zeige HIF1A Proteine)

  3. mRNA of HIF-2alpha (zeige EPAS1 Proteine) and Ets-1 (zeige ETS1 Proteine) were significantly increased by HIF-3alpha ablation. Both factors activate the VE-cadherin (zeige CDH5 Proteine) gene, the transcriptional repression of these factors by HIF-3alpha is important for silencing the irrelevant expression of the VE-cadherin (zeige CDH5 Proteine) gene.

  4. our data indicated that Tnni2K175del mutation led to abnormally increased hif3a and decreased vegf (zeige VEGFA Proteine) in bone, which explain, at least in part, the small body size of Tnni2K175del mice

  5. Anoxia preconditioning increases anti-ischemic neuronal resistance which to a certain extent correlates with the changes of HIF-1alpha (zeige HIF1A Proteine) and HIF-3alpha expression.

  6. alternative splicing and expression of IPAS is induced by hypoxia.

  7. By generating mice with a targeted disruption of the NEPAS/HIF-3alpha locus, it was found that homozygous mutant mice, NEPAS/HIF-3alpha(-/-), were viable but displayed enlargement of the right ventricle and impaired lung remodeling.

  8. Identity of third HIF alpha class member, HIF-3alpha. mRNA expression information by mouse MTN. Experimental proof of dimerization with ARNT/HIF-1beta (zeige ARNT Proteine).

Zebrafish Hypoxia Inducible Factor 3, alpha Subunit (HIF3A) Interaktionspartner

Cow (Bovine) Hypoxia Inducible Factor 3, alpha Subunit (HIF3A) Interaktionspartner

HIF3A Protein Überblick

Protein Überblick

The protein encoded by this gene is the alpha-3 subunit of one of several alpha/beta-subunit heterodimeric transcription factors that regulate many adaptive responses to low oxygen tension (hypoxia). The alpha-3 subunit lacks the transactivation domain found in factors containing either the alpha-1 or alpha-2 subunits. It is thought that factors containing the alpha-3 subunit are negative regulators of hypoxia-inducible gene expression. Multiple alternatively spliced transcript variants have been found for this gene.

Genbezeichner und Symbole assoziert mit HIF3A

  • hypoxia inducible factor 3 alpha subunit (HIF3A)
  • hypoxia inducible factor 3, alpha subunit (Hif3a)
  • hypoxia-inducible factor 1, alpha subunit, like (hif1al)
  • bHLHe17 Protein
  • HIF-3A Protein
  • HIF3A Protein
  • Ipas Protein
  • Mop7 Protein
  • NEPAS Protein
  • PASD7 Protein
  • zgc:63965 Protein

Bezeichner auf Proteinebene für HIF3A

HIF3-alpha-1 , PAS domain-containing protein 7 , basic-helix-loop-helix-PAS protein MOP7 , class E basic helix-loop-helix protein 17 , hypoxia-inducible factor 3-alpha , inhibitory PAS domain protein , member of PAS protein 7 , HIF-3-alpha , HIF3-alpha , hypoxia inducible factor three alpha , neonatal and embryonic PAS , HIF-3 alpha , HIF3 alpha 1 , hypoxia inducible factor 3 alpha , hypoxia inducible factor 3a , hypoxia-inducible factor 3 alpha , Hif3a , Hif3a-like , hypoxia-inducible factor 3 alpha subunit , hypoxia inducible factor 3, alpha subunit , hypoxia-inducible factor-3 alpha , hypoxia-inducible factor 3-alpha-like

GENE ID SPEZIES
64344 Homo sapiens
53417 Mus musculus
64345 Rattus norvegicus
393376 Danio rerio
456149 Pan troglodytes
476429 Canis lupus familiaris
507699 Bos taurus
100135687 Ovis aries
100413902 Callithrix jacchus
100442498 Pongo abelii
100473029 Ailuropoda melanoleuca
100582446 Nomascus leucogenys
100621574 Sus scrofa
100071095 Equus caballus
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