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Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Zusätzlich bieten wir Ihnen HIP1R Antikörper (84) und und viele weitere Produktgruppen zu diesem Protein an.
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HIP1R rescued miR-23b/-27b-mediated repression of migration in prostate cancer cells. HIP1R mRNA levels were decreased in seminal vesicle tissue from mice bearing miR-23b/-27b-transduced prostate cancer cell xenografts compared with scrambled controls, suggesting HIP1R is a key functional target of miR-23b/-27b.
our findings support the conclusion that the rs12817488 in CCDC62/HIP1R polymorphism may increase the risk of Parkinson's disease in the Chinese Han population.
We conclude that HIP1R expression is strongly indicative of survival in diffuse large B-cell lymphoma
STK39 (rs2102808) and CCDC62/HIP1R (rs12817488) do not appear to influence PD risk.
HIP1r plays an important role in regulating the attachment of spindle microtubules to chromosomes during mitosis, an event that is required for accurate congression and segregation of chromosomes.
HIP1 and HIP12 display differential binding to F-actin, AP2, and clathrin. Identification of a novel interaction with clathrin light chain. (HIP12)
both HIP1r and HIP1 bind inositol lipids via their epsin N-terminal homology (ENTH) domains
Hip1R has a role in making the interaction between actin and the endocytic machinery functional and transient
The F-actin binding capacity of Hip12 is regulated by intrasteric occlusion of primary actin-binding determinants within the Hip12 I/LWEQ module.
the stability of intergenerational transmission of a variable number tandem repeat (VNTR) polymorphism, found in the Huntingtin interacting protein-1 related gene (HIP12/HIP1R) that is mapped to the chromosome 12q24.31 region.
characterize the F-actin-binding region of HIP1R, termed the talin-HIP1/R/Sla2p actin-tethering C-terminal homology (THATCH) domain
Human HIP1 transgenic Hip1/Hip1r knockout mice are completely free from dwarfism and spinal defects.
Neuronal dysfunction in transgenic Caenorhabditis elegans expressing mutant N-terminal huntingtin is specifically enhanced by hipr-1 loss of function.
in mammalian cells CLCs function in intracellular membrane trafficking by acting as recruitment proteins for HIP1R, enabling HIP1R to regulate actin assembly on clathrin-coated structures
Actin binding by Hip1 (huntingtin-interacting protein 1) and Hip1R (Hip1-related protein) is regulated by clathrin light chain
This study provided the previously unknown function of HIP1R involved in the intrinsic cell death pathway and further explored possible mechanisms by which HIP1R induces cell death.
Nptx1, Hip1r, and Hdac9 as genes whose expression is altered by HDAC3.
Specific expression of mHip1r in the embryonic brain and secretory glands suggests a possible role for Hip1r in normal development and in the pathology of HD.
IFNgamma was required for the mucous cell hypertrophy and hyperplasia observed in Hip1r-deficient mice. IFNgamma is critical for the development of the gastric epithelial cell metaplasia that results from parietal cell atrophy in the Hip1r-deficient mice.
This study characterized gastric gland development in wild-type and Hip1r-deficient mice to define normal development, as well as the timing and sequence of the cellular transformation events in the mutant stomach.
mice deficient in both HIP1 and HIP1r have accelerated development of abnormalities seen in Hip1 -deficient mice, including kypholordosis and growth defects
roles of Hip1 and Hip1R in affecting clathrin assembly and actin distribution are mediated by their interaction with the conserved sequence of clathrin light chains.
Degenerative phenotypes seen in knockout mice are due mainly to HIP1 and HIP1r protein deficiency rather than altered expression of neighboring genes or disrupted intronic elements.
Hip1r plays a significant role in gastric physiology, mucosal architecture, and secretory membrane dynamics in parietal cells.
Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3- phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis.
, HIP1-related protein
, huntingtin interacting protein 12
, huntingtin-interacting protein 1-related protein
, huntingtin-interacting protein 12
, huntingtin interacting protein 1 related
, huntingtin interacting protein-1-related
, huntingtin interacting protein 1-related
, huntingtin-interacting protein 1-related protein-like
, huntingtin interacting protein 1