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HESX1 encodes a conserved homeobox protein that is a transcriptional repressor in the developing forebrain and pituitary gland. Zusätzlich bieten wir Ihnen HESX Homeobox 1 Proteine (12) und HESX Homeobox 1 Kits (2) und viele weitere Produktgruppen zu diesem Protein an.
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Hesx1 plays a significant role in sustaining pluripotency in embryonic stem cells.Hesx1 transcriptionally suppresses differentiation-related genes.
Wnt (zeige WNT2 Antikörper) inhibition during the first day has larger impact on the activation of Hesx1 and Six3, suggesting that in embryos Wnt (zeige WNT2 Antikörper) inhibition caused by Dkk1 (zeige DKK1 Antikörper) contributes greatly in the establishment of the anterior forebrain precursor.
Variability in Hes1 (zeige HES1 Antikörper) expression therefore helps to explain why STAT3 (zeige STAT3 Antikörper) responsiveness varies between individual ES cells, and this in turn helps to explain why pluripotent cells commit to differentiate asynchronously..
Transcriptional profiling of anterior forebrain precursors from mouse embryos expressing eGFP from the Hesx1 locus provides molecular evidence supporting a novel function of Hesx1 in mediating repression of Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) target activation.
Studies suggest that TLE1 (zeige TLE1 Antikörper) and TLE3 (zeige TLE3 Antikörper) might also play roles independent of HESX1 by interacting with other transcription factors like PROP1 (zeige PROP1 Antikörper).
Data suggest that formation of a heterodimer between HESX1 and PROP1 (zeige PROP1 Antikörper) allows HESX1 to become active, and that PROP1 (zeige PROP1 Antikörper) then replaces HESX1 to advance to the middle stage of pituitary development.
A novel inducible element, activated by contact with Rathke's pouch, is present in the regulatory region of the Hesx1 homeobox (zeige PRRX1 Antikörper) gene.
the domains of Hes-1 (zeige HES1 Antikörper) needed to block adipogenesis coincide with those necessary for transcriptional repression.
Conserved regulatory elements establish the dynamic expression of Rpx in early development.
The absence of Hesx1 leads to a posterior transformation of the anterior forebrain (AFB) during mouse development.
HESX1 mutations cause variable clinical features in congenital hypopituitarism patients, which suggests an influence of modifier genes or environmental factors on the phenotype
A novel heterozygous mutation in the HESX1 gene and a novel homozygous mutation in the PROP1 (zeige PROP1 Antikörper) gene were detected in 2 pedigrees with combined pituitary hormone (zeige CGA Antikörper) deficiency
investigated the specific mutations in PROP1 (zeige PROP1 Antikörper), POU1F1 (zeige POU1F1 Antikörper), LHX3 (zeige LHX3 Antikörper), and HESX1 genes in patients with combined pituitary hormone (zeige CGA Antikörper) deficiency (CPHD) in Turkey
Data indicate that HESX1, LHX4 (zeige LHX4 Antikörper) and SOX3 (zeige SOX3 Antikörper) polymorphisms may be associated with pituitary stalk interruption syndrome (PSIS).
expand the phenotypic spectrum of HESX1 mutations in Kallman syndrome.
Data show no mutations in HESX1, PROP1 (zeige PROP1 Antikörper), and POU1F1 (zeige POU1F1 Antikörper) genes, seven different mutations in CTNNB1 (zeige CTNNB1 Antikörper) in 8/16 patients, and hyperexpression of miR (zeige MLXIP Antikörper)-150.
A c.357+3G>A mutation prevents the generation of one of the alternative isoforms normally produced by the wild-type allele, predicting a truncated HESX1 protein.
A novel HESX1 causative mutation was found in a consanguineous family, and two LHX4 (zeige LHX4 Antikörper) mutations were present in familial Pituitary stalk interruption syndrome.
Mutations in the PROP1 (zeige PROP1 Antikörper) and HESX1 genes were not identified in these patients with sporadic growth hormone (zeige GH1 Antikörper) defiency, combined pituitary hormone (zeige CGA Antikörper) deficiency and septo-optic dysplasia.
A large cohort of patients with schizencephaly, some with features of septo-optic dysplasia, were sequenced for mutations in LHX2 (zeige LHX2 Antikörper), HESX1 and SOX2 (zeige SOX2 Antikörper).
Using specific regulatory elements from the Xanf1/Hesx1 promoter, study show that Xanf1/Hesx1-SoxD/Sox15-heterodimer can bind to these elements and stabilizes Xanf1/Hesx1 expression. This result explains how Xanf1/Hesx1 can escape inhibition by its own protein product and is consistent with the current model which proposes that Sox proteins regulate gene expression by forming complexes with other transcription factors.
X-nkx-5.1 is stage-specific inhibitor of Xanf-1 in the anterior neural plate during the Xenopus development
These results are consistent with a possible role of Zyxin as a negative modulator of Xanf1 transcriptional repressing activity.
binding of the LIM2 domain of zyxin with the Engrailed Homology 1 repressor domain of Xanf1 is responsible for the interaction of these proteins.
This gene encodes a conserved homeobox protein that is a transcriptional repressor in the developing forebrain and pituitary gland. Mutations in this gene are associated with septooptic dysplasia, HESX1-related growth hormone deficiency, and combined pituitary hormone deficiency.
anterior-restricted homeobox protein
, homeo box gene expressed in ES cells
, homeobox expressed in ES cells 1
, homeobox protein ANF
, rathke pouch homeo box
, Rathke pouch homeobox
, homeobox, ES cell expressed 1
, homeo box (expressed in ES cells) 1
, Homeobox protein ANF-1
, homeobox expressed in ES cells 1-B
, anterior neural fold protein
, homeobox protein ANF-1
, homeobox protein GANF
, homeodomain-containing protein
, anterior neural folds homolog