HECT, C2 and WW Domain Containing E3 Ubiquitin Protein Ligase 2 Proteine (HECW2)

E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Zusätzlich bieten wir Ihnen HECW2 Antikörper (52) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
Ratte HECW2 HECW2 316395  
HECW2 57520 Q9P2P5
HECW2 329152 Q6I6G8
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Showing 4 out of 4 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$13,984.89
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$13,984.89
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$814.00
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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HECW2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine)

Weitere Proteine zu HECT, C2 and WW Domain Containing E3 Ubiquitin Protein Ligase 2 (HECW2) Interaktionspartnern

Human HECT, C2 and WW Domain Containing E3 Ubiquitin Protein Ligase 2 (HECW2) Interaktionspartner

  1. HECW2, a novel EC ubiquitin E3 ligase, plays a critical role in stabilizing endothelial cell-to-cell junctions by regulating AMOT-like 1 (AMOTL1) stability.

  2. HECW2 is an ubiquitin ligase that stabilises p73 (zeige TP73 Proteine), a crucial mediator of neurodevelopment and neurogenesis. This study implicates pathogenic genetic variants in HECW2 as potential causes of neurodevelopmental disorders in humans.

  3. This work lends further support to previously identified candidate gene HECW2 as a novel candidate gene in intellectual disability and epilepsy. In 39 patient-parent trios, 29 de novo mutations in coding sequence were identified.

  4. Low HECW2 expression is associated with cervical cancer.

  5. NEDL2 is a novel substrate of APC (zeige APC Proteine)/C-Cdh1 (zeige CDH1 Proteine) as cells exit mitosis and functions as a regulator of the metaphase to anaphase transition

Mouse (Murine) HECT, C2 and WW Domain Containing E3 Ubiquitin Protein Ligase 2 (HECW2) Interaktionspartner

  1. Data show that NEDL2 regulates GDNF/Ret/Akt pathway depends on its Nedd8 ligase activity rather than ubiquitin ligase activity.

  2. NEDL2 positively regulates enteric neural precursor proliferation through the GDNF/Akt (zeige AKT1 Proteine) signaling pathway.

  3. Grk2 (zeige ADRBK1 Proteine) phosphorylates the C terminus of the Na-channel beta subunit (zeige POLG Proteine) and renders the channels insensitive to inhibition by Nedd4-2 (zeige NEDD4L Proteine)

HECW2 Protein Überblick

Protein Überblick

E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73 (By similarity).

Genbezeichner und Symbole assoziert mit HECW2

  • HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 (Hecw2)
  • HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 (HECW2)
  • E3 ubiquitin-protein ligase HECW2 (LOC531691)
  • HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2b (hecw2b)
  • HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 (hecw2)
  • A730039N16Rik Protein
  • D030049F17Rik Protein
  • Gm971 Protein
  • HECW2 Protein
  • mKIAA1301 Protein
  • Nedl2 Protein

Bezeichner auf Proteinebene für HECW2

E3 ubiquitin-protein ligase HECW2 , HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 , E3 ubiquitin-protein ligase HECW2-like , e3 ubiquitin-protein ligase HECW2-like , HECT, C2 and WW domain-containing protein 2 , NEDD4-like E3 ubiquitin-protein ligase 2 , NEDD4-related E3 ubiquitin ligase NEDL2

GENE ID SPEZIES
316395 Rattus norvegicus
424050 Gallus gallus
459844 Pan troglodytes
531691 Bos taurus
100055015 Equus caballus
100331355 Danio rerio
100411186 Callithrix jacchus
100444189 Pongo abelii
100469664 Ailuropoda melanoleuca
100560989 Anolis carolinensis
100602550 Nomascus leucogenys
57520 Homo sapiens
329152 Mus musculus
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