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E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Zusätzlich bieten wir Ihnen HECW2 Antikörper (53) und viele weitere Produktgruppen zu diesem Protein an.
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Results show that HECW2 interacts with two lamin A-binding proteins: proliferating cell nuclear antigen (PCNA), via a canonical PCNA-interacting protein (PIP) motif, and lamin B1. HECW2 mediates their ubiquitination and targets them for proteasomal degradation.
HECW2, a novel EC ubiquitin E3 ligase, plays a critical role in stabilizing endothelial cell-to-cell junctions by regulating AMOT-like 1 (AMOTL1) stability.
HECW2 is an ubiquitin ligase that stabilises p73, a crucial mediator of neurodevelopment and neurogenesis. This study implicates pathogenic genetic variants in HECW2 as potential causes of neurodevelopmental disorders in humans.
This work lends further support to previously identified candidate gene HECW2 as a novel candidate gene in intellectual disability and epilepsy. In 39 patient-parent trios, 29 de novo mutations in coding sequence were identified.
Low HECW2 expression is associated with cervical cancer.
NEDL2 is a novel substrate of APC/C-Cdh1 as cells exit mitosis and functions as a regulator of the metaphase to anaphase transition
Data show that NEDL2 regulates GDNF/Ret/Akt pathway depends on its Nedd8 ligase activity rather than ubiquitin ligase activity.
NEDL2 positively regulates enteric neural precursor proliferation through the GDNF/Akt signaling pathway.
Grk2 phosphorylates the C terminus of the Na-channel beta subunit and renders the channels insensitive to inhibition by Nedd4-2
E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73 (By similarity).
E3 ubiquitin-protein ligase HECW2
, HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
, E3 ubiquitin-protein ligase HECW2-like
, e3 ubiquitin-protein ligase HECW2-like
, HECT, C2 and WW domain-containing protein 2
, NEDD4-like E3 ubiquitin-protein ligase 2
, NEDD4-related E3 ubiquitin ligase NEDL2