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Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria. Zusätzlich bieten wir Ihnen GFM1 Antikörper (74) und GFM1 Kits (11) und viele weitere Produktgruppen zu diesem Protein an.
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Functional studies demonstrated decreased GFM1 protein levels, suggested disrupted assembly of mitochondrial complexes III and V and decreased activities of mitochondrial complexes I and IV, all indicating combined OXPHOS deficiency.
In the present study, a nanoparticle modified with EGFP-EGF1 (ENP) was constructed as a multitargeting drug delivery system. The protein binding experiment showed EGFP-EGF1 could bind well to A549 tumor cells and other stromal cells including neo-vascular cells, tumor-associated fibroblasts, and tumor-associated macrophages
The R671C mutation disrupts an inter-subunit interface and could locally destabilize the mutant protein. The second mutation (L398P) disrupted the H-bond network in a rich-beta-sheet domain, and may have a dramatic effect on local structure.
analysis of molecular model for EF-G1 isoform
Sequencing of EFG1 revealed a mutation affecting a conserved residue of the guanosine triphosphate (GTP)-binding domain. These results define a new class of gene defects underlying disorders of oxidative phosphorylation.
mutations in the mitochondrial translation factor EFG1 may have a role in oxidative phosphorylation deficiencies [case report]
Genetic investigation of patients with defective mitochondrial translation led to the discovery of novel mutations in the mitochondrial elongation factor G1 (EFG1) in one affected baby and in the mitochondrial elongation factor Tu (EFTu) in another one
Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory chain-oxidative phosphorylation system and to impaired maintenance of mitochondrial DNA. This gene encodes one of the mitochondrial translation elongation factors. Its role in the regulation of normal mitochondrial function and in different disease states attributed to mitochondrial dysfunction is not known.
, G translation elongation factor, mitochondrial
, elongation factor G 1, mitochondrial
, elongation factor G, mitochondrial
, elongation factor G1
, mEF-G 1
, mitochondrial elongation factor G
, mitochondrial elongation factor G1
, G elongation factor 1