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FLI1 encodes a transcription factor containing an ETS DNA-binding domain. Zusätzlich bieten wir Ihnen Friend Leukemia Virus Integration 1 Antikörper (184) und Friend Leukemia Virus Integration 1 Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.
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Low FLII (zeige FLII ELISA Kits) expression is associated with lung carcinoma.
These results indicate that Fli1 deficiency promotes migration, proliferation and cell survival, while abating tube formation of endothelial cells, suggesting that Fli1 deficiency is potentially attributable to the development of both proliferative obliterative vasculopathy (occlusion of arterioles and small arteries) and destructive vasculopathy (loss of small vessels) characteristic of SSc (zeige CYP11A1 ELISA Kits) vasculopathy.
Fli1 functioned as an oncogene (zeige RAB1A ELISA Kits) in HCC carcinogenesis and it exerted its promoting metastatic effect primarily by modulating the matrix metalloproteinase (MMP)2 (zeige MMP2 ELISA Kits) signaling pathway.
Decreased serum LIF levels may be associated with vasculopathy in systemic sclerosis (SSc) and that Fli1 deficiency may contribute to the inhibition of LIF-dependent biological effects on SSc endothelial cells by suppressing the expression of LIF, LIF receptor, and gp130.
Studies demonstrate that the translocation-derived fusion protein EF (EWS (zeige EWSR1 ELISA Kits)-FLI1) misregulates numerous genes involved in metabolism suggesting that EF is a master regulator of metabolic reprogramming in Ewing sarcoma, diverting metabolites toward biosynthesis.
Data show that the ability of Ca(2+) to accentuate the activity of NLRP3 inflammasome is abrogated in Flightless-I (FliI) and leucine-rich repeat FliI-interaction protein 2 (LRRFIP2)-knockdown macrophages.
Together, the data demonstrate the critical requirement of GGAA-microsatellites as EWS (zeige EWSR1 ELISA Kits)/FLI (zeige FLII ELISA Kits) activating response elements in vivo and reveal an unexpected role for the EWS (zeige EWSR1 ELISA Kits) portion of the EWS (zeige EWSR1 ELISA Kits)/FLI (zeige FLII ELISA Kits) fusion in binding to sweet-spot GGAA-microsatellites.
FLII is a component of the ChREBP transcriptional complex and negatively regulates ChREBP function in cancer cells.
Demonstrate an important role for Flii (zeige FLII ELISA Kits) in the development and regulation of the epidermal barrier, which may contribute to the impaired healing and skin fragility of epidermolysis bullosa patients.
The gene that was most reproducibly up-regulated by EWS/FLI was NR0B1.
Histones showed limited activation in regions of single TF binding, while enhancers that bind NF-E2 and either RUNX1 (zeige RUNX1 ELISA Kits), FLI1 or both TFs gave the highest signals for TF occupancy and H3K4me2; these enhancers associated best with genes activated late in MK maturation.
loss of ERG (zeige ERG ELISA Kits) and FLI1 might contribute to the pathogenesis of vascular lung complications through the induction of inflammation.
These results provide the first evidences that Fli-1 positively regulates LPS (zeige TLR4 ELISA Kits)-induced IL-27 (zeige IL27 ELISA Kits) production in macrophages
protective against nephritis MRL/lpr (zeige FAS ELISA Kits) mice
Fli1 is epigenetically suppressed and is a potential predisposing factor in the pathogenesis of systemic sclerosis. (Review)
The short nose, otitis media, and hearing impairment in Jacobsen syndrome are likely because of hemizygosity for ETS1 (zeige ETS1 ELISA Kits) and FLI1.
Simultaneous downregulation of KLF5 (zeige KLF5 ELISA Kits) and Fli1 is a key feature underlying systemic sclerosis.
bosentan...increased DNA binding of Fli1 and the suppression of type I collagen expression in systemic sclerosis fibroblasts
FLI1 and GATA2 (zeige GATA2 ELISA Kits) are upstream regulators of SMAD1 (zeige SMAD1 ELISA Kits) and SMAD5 (zeige SMAD5 ELISA Kits) expression in endothelial cells.
mesodermal Wnt3a (zeige WNT3A ELISA Kits)-mediated signaling via the transcription factor Lef1 (zeige LEF1 ELISA Kits) positively regulates EC specification (defined by kdrl expression) at the expense of primitive erythrocyte specification (defined by gata1 (zeige GATA1 ELISA Kits) expression) in zebrafish embryos.
Fli+ etsrp+ hemato-vascular progenitor cells proliferate at the lateral plate mesoderm during vasculogenesis in zebrafish.
These results showed that young thrombocytes have higher GATA1 (zeige GATA1 ELISA Kits) promoter activity, while mature thrombocytes have more fli1 gene promoter transcription.
fli1, and etsrp, demonstrated that erg and fli1 act cooperatively and are required for angiogenesis possibly via direct regulation of an endothelial cell junction molecule, VE-cadherin (zeige CDH5 ELISA Kits)
Interaction between EWSR1 (zeige EWSR1 ELISA Kits)/FLI1 and EWSR1 (zeige EWSR1 ELISA Kits) in Ewing sarcoma may induce mitotic defects leading to genomic instability and subsequent malignant transformation.
This gene encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain. The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. The gene is located within the Smith-Magenis syndrome region on chromosome 17.
Ewing sarcoma breakpoint region 2
, Friend leukemia integration 1 transcription factor
, Friend leukemia virus integration 1
, proto-oncogene Fli-1
, transcription factor ERGB
, protein flightless-1 homolog
, fli-1 proto-oncogene
, friend leukemia integration 1 transcription factor-like
, Friend leukemia integration 1 transcription factor-like
, retroviral integration site protein Fli-1
, retroviral integration site protein Fli-1 homolog