Fermitin Family Member 3 Proteine (FERMT3)

Kindlins are a small family of proteins that mediate protein-protein interactions involved in integrin activation and thereby have a role in cell adhesion, migration, differentiation, and proliferation. Zusätzlich bieten wir Ihnen FERMT3 Antikörper (76) und FERMT3 Kits (9) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
Maus FERMT3 FERMT3 108101 Q8K1B8
FERMT3 83706 Q86UX7
Ratte FERMT3 FERMT3 309186  
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Showing 3 out of 3 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,797.11
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$547.80
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FERMT3 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,

Weitere Proteine zu Fermitin Family Member 3 (FERMT3) Interaktionspartnern

Xenopus laevis Fermitin Family Member 3 (FERMT3) Interaktionspartner

Mouse (Murine) Fermitin Family Member 3 (FERMT3) Interaktionspartner

  1. Structure and lipid-binding properties of the kindlin-3 pleckstrin (zeige PLEK Proteine) homology domain has been reported.

  2. Mice expressing as little as 5% of kindlin-3 were viable and protected from spontaneous bleeding and infections. In vitro platelet functions, leukocyte adhesion, extravasation, and bacterial clearance were diminished. Bleeding time increased.

  3. The accumulation of HSPCs in the circulation of leukocyte adhesion deficiency type III patients, who lack Kindlin-3, underlines the conserved functions of Kindlin-3 in man and the importance of our findings for human disease.

  4. Optimal T cell activation and B cell antibody responses in vivo require the interaction between Integrin beta2 and kindlin-3.

  5. Direct binding of kindlin-3 to integrin alphaIIbbeta3 is involved in supporting integrin alphaIIbbeta3 activation and integrin alphaIIbbeta3-dependent responses of platelets and consequently contributes significantly to arterial thrombus formation.

  6. ADAP interacts with talin and kindlin-3 to promote platelet Integrin alphaIIbbeta3 activation and stable fibrinogen binding.

  7. the requirement of Kindlin-3 for effector T cells to induce alpha4beta1 and alphaLbeta2 integrin ligand binding and stabilization of integrin-ligand bonds is critical when integrin ligand levels are low, but of less importance when integrin ligand levels are high.

  8. This is the first in vivo demonstration that Kindlin-3-stabilized integrin adhesions, although essential for lymphocyte arrest on blood vessels and interstitial motility, are not obligatory for leukocyte diapedesis.

  9. the beta-2-integrin-kindlin-3 interaction is particularly important in adhesion strengthening under shear flow, and for T-cell homing to lymph nodes, but dispensable for T cell activation which occurs in a shear-free environment

  10. Kindlin-3 is central to conversion of mechanical force to intracellular signaling via calcium influx.

Human Fermitin Family Member 3 (FERMT3) Interaktionspartner

  1. FERMT3 regulates glioma cell activity through integrin-mediated Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signaling.

  2. this case report describes a female Thai patient who was diagnosed with leukocyte adhesion deficiency type III with a novel mutation in FERMT3, presenting with a humoral immune defect

  3. kindlin-3 plays an important role in maintaining a proper conformation of the resting alpha4beta1 to mediate both rolling and firm cell adhesion

  4. Kindlin-3 regulates c-Myc (zeige MYC Proteine) protein expression in the human chronic myeloid leukemia (zeige BCL11A Proteine) cell line K562.

  5. NMR studies demonstrated that the F1 loop of kindlin-3 is globally unfolded but stretches of residues assuming transient helical conformations could be detected in aqueous solution.

  6. Suppression of the Kindlin-2 (zeige FERMT2 Proteine)-integrin beta1-AKT (zeige AKT1 Proteine) regulatory axis is an alternative mechanism underlying the tumor suppressor function of miR (zeige MLXIP Proteine)-200b in esophageal squamous cell carcinoma.

  7. Kindlin-3/FERMT3 is upregulated in atherosclerotic, mainly in cells of monocytic origin and of M2 type. Simultaneous upregulation of ITGB2 (zeige ITGB2 Proteine) suggests a synergistic effect on leukocyte adherence and transmigration into the vessel wall.

  8. The accumulation of HSPCs in the circulation of leukocyte adhesion deficiency type III patients, who lack Kindlin-3, underlines the conserved functions of Kindlin-3 in man and the importance of our findings for human disease.

  9. A new C>T point mutation was found in exon 13 in the FERMT3 gene in an infant diagnosed with LAD (zeige DLD Proteine)-III. KINDLIN-3 expression is required for platelet aggregation and leukocyte function, but also osteoclast-mediated bone resorption.

  10. Mig-2 (zeige FERMT2 Proteine) significantly attenuates the antitumor action of cisplatin.

FERMT3 Protein Überblick

Protein Überblick

Kindlins are a small family of proteins that mediate protein-protein interactions involved in integrin activation and thereby have a role in cell adhesion, migration, differentiation, and proliferation. The protein encoded by this gene has a key role in the regulation of hemostasis and thrombosis. This protein may also help maintain the membrane skeleton of erythrocytes. Mutations in this gene cause the autosomal recessive leukocyte adhesion deficiency syndrome-III (LAD-III). Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Genbezeichner und Symbole assoziert mit FERMT3

  • fermitin family member 3 L homeolog (fermt3.L)
  • fermitin family member 3 (fermt3)
  • fermitin family member 3 (FERMT3)
  • fermitin family member 3 (Fermt3)
  • C79673 Protein
  • KIND3 Protein
  • Kindlin3 Protein
  • MGC69069 Protein
  • MGC88900 Protein
  • MIG-2 Protein
  • MIG2B Protein
  • RGD1310168 Protein
  • UNC112C Protein
  • URP2 Protein
  • URP2SF Protein

Bezeichner auf Proteinebene für FERMT3

fermitin family member 3 , fermitin family homolog 3 , unc-112-related protein 2 , MIG2-like protein , UNC-112 related protein 2 , kindlin 3 , kindlin-3

GENE ID SPEZIES
379715 Xenopus laevis
448215 Xenopus (Silurana) tropicalis
100050011 Equus caballus
108101 Mus musculus
83706 Homo sapiens
483766 Canis lupus familiaris
309186 Rattus norvegicus
525159 Bos taurus
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