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Transcription factor that binds to the E-box and functions as inhibitor of transcription.
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Identification and genomic structure of Nato3 in fly, mouse and man. Nervous system expression detected in fly and mouse.
Nato3 induces ectopic Foxa2 (zeige FOXA2 Proteine)-positive cells and indirectly downregulates Nkx2.2 (zeige Nkx2-2 Proteine) expression.
Nato3 transcription is directly regulated by Foxa2 (zeige FOXA2 Proteine) and increases in parallel to differentiation of dopaminergic cells.
Data suggest that Nato3 is a direct target of Foxa2 (zeige FOXA2 Proteine), a transcription activator and effector of Sonic hedgehog (zeige SHH Proteine), the hallmark regulator of neural tube floor plate induction and spinal cord development.
in the developing mesencephalon, loss of Nato3 did not affect floor plate (FP) differentiation, but led to loss of neurogenic activity in the medial subpopulation of mesFP cells by suppressing proneural gene expression and inducing cell cycle arrest
Transcription factor that binds to the E-box and functions as inhibitor of transcription. DNA binding requires dimerization with an E protein. Inhibits transcription activation by ASCL1/MASH1 by sequestering E proteins.
, Fer3-like (Drosophila)
, nephew of atonal 3
, basic helix-loop-helix protein N-twist
, class A basic helix-loop-helix protein 31
, neuronal twist