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Functions as a receptor for the Fc fragment of IgA and IgM.
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A genome-wide trans-ethnic interaction study links the PIGR (zeige PIGR Proteine)-FCAMR locus to coronary atherosclerosis via interactions between genetic variants and residential exposure to traffic pollution.
rs3125923 FCAMR gene represents a validated SNP to predict grade 3-4 Taxane-induced peripheral neuropathy . Genetically determined AA race represents the most significant predictor of TIPN.
A significantly worse survival was found in patients with IgA serum levels>2.85 g/l compared to patients with lower IgA serum levels.
ADAM10 (zeige ADAM10 Proteine) and ADAM17 (zeige ADAM17 Proteine) are involved in the shedding of FcalphaR
LPS (zeige IRF6 Proteine), through the TLR4 (zeige TLR4 Proteine) receptor, activates the p38MAPK (zeige MAPK14 Proteine) and NF-kappaB (zeige NFKB1 Proteine) pathways and up-regulate the expression of Fcamr in human macrophages
These results indicate for the first time that Fcalpha/muR (zeige FCER2 Proteine) protein is expressed by human intestinal tissues
Serum IgA production against gut (zeige GUSB Proteine)-oriented antigens is negatively regulated by Fcalpha/muR (zeige FCER2 Proteine) on follicular dendritic cells in the F1 mice.
These results suggest that Fcalpha/muR (zeige FCER2 Proteine) enhances, rather than suppresses, autoantibody production.
Data suggest that Fcalpha/muR (zeige FCER2 Proteine) does not form homodimers, but forms heterodimers with an as-yet-unknown molecule with a molecular weight of 60-70 kDa.
A significant portion of the effector function of IgM, especially with regard to the enhancement of humoral immune responses and suppression of autoimmunity, is mediated by FcmuR.
Mice deficient in Fc alpha/muR have enhanced germinal center formation and affinity maturation and memory induction of IgG3(+) B cells after immunization with T-independent antigens.[Fc alpha/muR]
Functions as a receptor for the Fc fragment of IgA and IgM. Binds IgA and IgM with high affinity and mediates their endocytosis. May function in the immune response to microbes mediated by IgA and IgM.
Fc receptor, IgA, IgM, high affinity
, Fc alpha/mu receptor
, high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor
, high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor-like
, immunity related factor
, receptor for Fc fragment of IgA and IgM
, Fc IgA/IgM receptor
, Fca/m receptor
, fc alpha/mu receptor