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The Fos gene family consists of 4 members FOSL1, and FOSL2.
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Mouse (Murine) FOSL1 ELISA Kit - ABIN1053820
Chen, Wang, Chen, Zhang, Shen, Zhang, Chen: Activation of Toll-like receptors by intestinal microflora reduces radiation-induced DNA damage in mice. in Mutation research. Genetic toxicology and environmental mutagenesis 2014
constitutive activation and non-regulation of Fra-1 by bicalutamide in PC-3 cells suggested that Fra-1, probably a key component, involved in transition of aggressive androgen-independent PC-3 cells with poor prognosis.
the overexpression of Fra1 disrupted inflammatory cytokine secretion by medullary thymic epithelial cells in the myasthenia gravis thymus
Taken together, our results indicated that miR (zeige MLXIP ELISA Kits)-449 overexpression inhibited osteogenic differentiation of HG-FFA-treated hBMSCs through the Sirt1 (zeige SIRT1 ELISA Kits)/Fra-1 signal pathway.
These findings indicate that an aberrant Wnt (zeige WNT2 ELISA Kits)/beta-catenin (zeige CTNNB1 ELISA Kits) signalling leads to the epithelial-mesenchymal transition and drug resistance of glioma via Fra1 induction, which suggests novel therapeutic strategies for the malignant disease.
MUC1 (zeige MUC1 ELISA Kits) enhancement of ERK (zeige EPHB2 ELISA Kits) activation influences FRA-1 activity to modulate tumor migration, invasion and metastasis in a subset of pancreatic cancer cases
the results indicate that FRA1 promotes cancer growth through AKT (zeige AKT1 ELISA Kits), and enhances cancer cell migration through JNK/c-Jun, pinpointing FRA1 as a key integrator of JNK (zeige MAPK8 ELISA Kits) and AKT (zeige AKT1 ELISA Kits) signaling pathways and a potential therapeutic target for squamous cell carcinoma of the skin and head and neck squamous cell carcinoma.
Study shows that FOSL1 is the main immediate early AP-1 (zeige JUN ELISA Kits) member induced by melanoma oncogenes; found that FOSL1 is involved in melanoma cell migration as well as cell proliferation and anoikis-independent growth.
a Fra-1-miR (zeige MLXIP ELISA Kits)-134 axis drives a positive feedback loop that amplifies ERK (zeige EPHB2 ELISA Kits)/JNK (zeige MAPK8 ELISA Kits) signaling and reduces chemosensitivity in ovarian cancer cells.
PKCtheta (zeige PRKCQ ELISA Kits);-induced phosphorylations control the ability of Fra-1 to stimulate gene expression and breast cancer cell migration.
Multivariate analysis identified Fra-1 as an independent prognostic factor. Fra-1 may be involved in the progress of hepatocellular carcinoma and could be a promising molecular candidate in the diagnosis and treatment of hepatocellular carcinoma.
NF-kappaB (zeige NFKB1 ELISA Kits) and c-Jun (zeige JUN ELISA Kits) coregulate lipopolysaccharide-induced Fra-1 transcription.
Upon stimulation with poly(I:C), malaria parasite-infected red blood cells (iRBCs), or vesicular stomatitis virus (VSV), FOSL1 "translocated" from the nucleus to the cytoplasm, where it inhibited the interactions between TNF receptor-associated factor 3 (TRAF3 (zeige TRAF3 ELISA Kits)), TIR domain-containing adapter inducing IFN-beta (zeige IFNB1 ELISA Kits) (TRIF), and Tank-binding kinase 1 (TBK1 (zeige TBK1 ELISA Kits)) via impairing K63-linked polyubiquitination of TRAF3 (zeige TRAF3 ELISA Kits) and TRIF.
Adipose-derived stromal cells overexpressing Fra-1 effectively protect against osteoarthritis.
Overexpression of Fosl1, which encodes a component of the AP-1 (zeige JUN ELISA Kits) transcription factor complex, in osteoblasts significantly blocked malleal capillary narrowing.
Fra-1 gene expression is activated in response lipopolysaccharide induced lung-injury in mice.
Data suggest that expression of Fra1 (fos-related antigen 1) in preadipocytes is up-regulated by arachidonic acid (AA) during late stages of adipogenesis; however, in early stage of adipogenesis, AA inhibits adipogenesis via Fra1-dependent mechanism.
Fra-1 plays a key role in promoting chronic CS-induced lung macrophagic inflammation in vivo
we demonstrate that Fra1 negatively controls plasma cell differentiation by repressing Blimp1 (zeige PRDM1 ELISA Kits) expression.
observations suggest that MyoD (zeige MYOD1 ELISA Kits) and pRb (zeige PGR ELISA Kits) work together cooperatively at the level of the intronic enhancer of Fra-1 during terminal cell cycle arrest
findings, based on a definitive genetic mouse model provide fundamental insights into mammary duct maturation and homeostasis and reveal that Scrib (zeige SCRIB ELISA Kits) loss activates a MAPK (zeige MAPK1 ELISA Kits)/Fra1 pathway that alters mammary progenitor activity
The Fos gene family consists of 4 members FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.
, fos-related antigen 1
, FOS-like antigen 1