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FBXW5 encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box.
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Human Polyclonal FBXW5 Primary Antibody für WB - ABIN1881341
Minoda, Sakurai, Kobayashi, Yoshimura, Takaesu: An F-box protein, FBXW5, negatively regulates TAK1 MAP3K in the IL-1beta signaling pathway. in Biochemical and biophysical research communications 2009
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oxidative stress induces Tnfaip8 (zeige TNFAIP8 Antikörper) l1/Oxi-beta, which results in increased autophagy by its exclusive binding with FBXW5 to stabilize TSC2 (zeige TSC2 Antikörper)
DLC1 (zeige DYNLL1 Antikörper) was ubiquitinated and degraded by cullin 4A (zeige CUL4A Antikörper)-RING ubiquitin ligase (CRL4A) complex interaction with DDB1 and the FBXW5 substrate receptor.
Identify Fbxw5-driven fluctuation of Eps8 (zeige EPS8 Antikörper) levels as an important mechanism that contributes to cell-shape changes during entry into-and exit from-mitosis.
Fbxw5 enhances sumoylation of nuclear c-Myb (zeige MYB Antikörper)
FBXW5 levels are controlled by the anaphase-promoting (APC (zeige APC Antikörper)/C) complex, which targets FBXW5 for degradation during mitosis and G1, thereby helping to reset the centrosome duplication machinery.
Results indicate that FBW5-DDB1-CUL4-ROC1 (zeige RIT1 Antikörper) is an E3 ubiquitin ligase (zeige MUL1 Antikörper) regulating TSC2 (zeige TSC2 Antikörper) protein stability and TSC (zeige SLC12A3 Antikörper) complex turnover.
These results suggest that FBXW5 negatively regulates TAK1 (zeige MAP3K7 Antikörper) in the IL-1beta (zeige IL1B Antikörper) signaling pathway.
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented.
F-box and WD-40 domain protein 5
, F-box/WD repeat-containing protein 5
, F-box and WD-40 domain-containing protein 5
, WD repeat-containing F-box protein FBW5
, F-box protein Fbw5