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FBXL6 encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box.
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Fbl6 (zeige FBXL7 Proteine) regulates Tel (zeige ETV6 Proteine)/Yan protein stability and allows appropriate spatiotemporal control of gene expression by these repressors.
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats. Alternative splicing of this gene generates 2 transcript variants.
F-box and leucine-rich repeat protein 6
, F-box protein Fbl6
, F-box/LRR-repeat protein 6
, F-box protein FBL6
, F-box protein containing leucine repeats 6