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Members of the F-box protein family, such as FBXO10, are characterized by an approximately 40-amino acid F-box motif.
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siRNA-mediated knockdown of FBXO11 (zeige FBXO11 Proteine) facilitated HIF-1alpha (zeige HIF1A Proteine) expression in various cancer cells and HIF-1alpha (zeige HIF1A Proteine)-driven gene expressions, but the FBXO10 knockdown did not.
Higher Fbxo10 expression in T cells is associated with Mcs5a increased susceptibility alleles
FBXO10, a protein related to DRE-1 (zeige KLHL24 Proteine), binds BCL2 (zeige BCL2 Proteine) and promotes its degradation, thereby initiating cell death. Moreover, some diffuse large B-cell lymphomas have inactivating mutations in FBXO10 or express FBXO10 at low levels.
Members of the F-box protein family, such as FBXO10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1\; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004
F-box protein 10
, f-box only protein 10-like
, F-box only protein 10
, F-box protein Fbx10