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EWSR1 encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. Zusätzlich bieten wir Ihnen EWSR1 Proteine (4) und EWSR1 Kits (3) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 152 products:
Human Polyclonal EWSR1 Primary Antibody für ICC, IF - ABIN152318
Davis, Kim, Ozsolak, Widlund, Rozenblatt-Rosen, Granter, Du, Fletcher, Denny, Lessnick, Linehan, Kung, Fisher: Oncogenic MITF dysregulation in clear cell sarcoma: defining the MiT family of human cancers. in Cancer cell 2006
Human Polyclonal EWSR1 Primary Antibody für IHC (p), IHC - ABIN449908
Toretsky, Erkizan, Levenson, Abaan, Parvin, Cripe, Rice, Lee, Uren: Oncoprotein EWS-FLI1 activity is enhanced by RNA helicase A. in Cancer research 2006
Human Polyclonal EWSR1 Primary Antibody für IP, WB - ABIN152319
Sohn, Park, Kang, Wu: Accumulation of pre-let-7g and downregulation of mature let-7g with the depletion of EWS. in Biochemical and biophysical research communications 2012
Authors found that FUS (zeige FUS Antikörper), EWS and TAF15 (zeige TAF15 Antikörper) expression is differentially regulated during brain development, both in time and in space. In particular, this study identifies a fine-tuned regulation of FUS (zeige FUS Antikörper) and EWS during neuronal differentiation.
Gnai1 (zeige GNAI1 Antikörper) function is impaired in the spinal cord of Ews/Ewsr1 KO mice
EWS is normally O-GlcNAc glycosylated in the brain.
glycosylation of EWS protein
EWSR1 is involved in the post-transcriptional regulation of Uvrag (zeige UVRAG Antikörper) via a miRNA-dependent pathway, resulting in the deregulation of autophagy inhibition.
EWS is essential during the early steps of white adipocyte differentiation, at least in part through its regulation of BMP2 (zeige BMP2 Antikörper) and BMP4 (zeige BMP4 Antikörper) expression.
EWS has a role in mitochondrial and cellular energy homeostasis that involves controlling PGC-1alpha protein stability
both Etv1 (zeige ETV1 Antikörper) and Ewsr1 were necessary for Fgf10 (zeige FGF10 Antikörper) expression and elongation of the limb bud.
EWS is involved in post-transcriptional regulation of Col4a1 (zeige COL4A1 Antikörper) and CTGF (zeige CTGF Antikörper) via a Drosha (zeige DROSHA Antikörper)-miRNA-dependent pathway.
These results demonstrate that EWS is essential for early brown fat lineage determination.
Mutation of the EWS gene modulates Sox9 (zeige SOX9 Antikörper) gene expression essential for chondrocyte differentiation.
Ewsr1 maintains mitotic integrity and proneural cell survival in early zebrafish development
Interaction between EWSR1/FLI1 (zeige FLI1 Antikörper) and EWSR1 in Ewing sarcoma may induce mitotic defects leading to genomic instability and subsequent malignant transformation.
EWSR1 Gene Rearrangement is associated with Endometrial Primitive Neuroectodermal Tumor.
-cell lymphoblastic leukemia with t(11;22)(q24;q12) and EWSR1 rearrangement.
Kinetics of EWSR1 fusion sequence copy numbers in the plasma are correlated with changes of the tumor volume in patients with localized and metastatic disease.
Recent advances in biologic and genomic understanding of these two cancers has expanded the potential for therapeutic advancement and prevention. In Ewing sarcoma, directed focus on inhibition of EWSR1-FLI1 (zeige FLI1 Antikörper) and its effectors has produced promising results.
data suggest EWS/FLI (zeige FLII Antikörper) binds to "promoter-like" and "enhancer-like" microsatellites to mediate activation and repression of target genes through different regulatory mechanisms
four oncogenic ETS (zeige ETS1 Antikörper) (ERG (zeige ERG Antikörper), ETV1 (zeige ETV1 Antikörper), ETV4 (zeige ETV4 Antikörper), and ETV5 (zeige ETV5 Antikörper)), and no other ETS (zeige ETS1 Antikörper), interact with the Ewing's sarcoma breakpoint protein, EWS.
As spontaneous fluctuations in EWS-FLI1 (zeige FLI1 Antikörper) levels of Ewing sarcoma cells in vitro and in vivo, associated with a switch between a proliferative, non-migratory EWS-FLI1 (zeige FLI1 Antikörper)-high and a non-proliferative highly migratory EWS-FLI1 (zeige FLI1 Antikörper)-low state, were recently described, our data provide a mechanistic basis for the underlying EWS-FLI1 (zeige FLI1 Antikörper)-dependent reversible cytoskeletal reprogramming of Ewing sarcoma cells.
Fusion of short fragments of EWSR1 to FLI1 (zeige FLI1 Antikörper) is sufficient to recapitulate BAF (zeige BANF1 Antikörper) complex retargeting and EWS-FLI1 (zeige FLI1 Antikörper) activities; studies thus demonstrate that the physical properties of prion (zeige PRNP Antikörper)-like domains can retarget critical chromatin regulatory complexes to establish and maintain oncogenic gene expression programs.
Case Reports: maxillary sinus clear cell carcinomas with EWSR1-ATF1 (zeige AFT1 Antikörper) gene fusion.
This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11\;22)(q24\;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14.
RNA-binding protein EWS
, Ewing sarcoma RNA-binding protein
, Ewing sarcoma breakpoint region 1
, Ewing sarcoma homolog
, Ewings sarcoma EWS-Fli1 (type 1) oncogene