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EIF4EBP2 encodes a member of the eukaryotic translation initiation factor 4E binding protein family. Zusätzlich bieten wir Ihnen eIF4EBP2 Proteine (13) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal eIF4EBP2 Primary Antibody für WB - ABIN1881292
Bidinosti, Martineau, Frank, Sonenberg: Repair of isoaspartate formation modulates the interaction of deamidated 4E-BP2 with mTORC1 in brain. in The Journal of biological chemistry 2010
Show all 3 Pubmed References
Results suggest that IGF2BP3 promotes eIF4E-mediated translational activation through the reduction of EIF4E-BP2 via mRNA degradation, leading to enhanced cell proliferation.
molecular dynamics simulations to investigate both the folded and unfolded states of 4E-BP2 under different phosphorylation states of T37 and T46
mTORC1 controls mitochondrial activity and biogenesis by selectively promoting translation of nucleus-encoded mitochondria-related mRNAs via inhibition of the eukaryotic translation initiation factor 4E (eIF4E (zeige EIF4E Antikörper))-binding proteins (4E-BPs).
Data show that the eIF4E (zeige EIF4E Antikörper) binding preference for 4E-BP2 over 4E-BP1 (zeige EIF4EBP1 Antikörper) is based on stacking of Arg63 side chain on Trp73 indole ring of eIF4E (zeige EIF4E Antikörper) and construction of hydrophobic space around the Trp73 indole ring by the Leu59-Leu60 sequence of 4E-BP2.
isoaspartate formation repair modulates the interaction of deamidated 4E-BP2 with mTORC1 in brain
4E-binding proteins, the suppressors of eukaryotic initiation factor 4E, are down-regulated in cells with acquired or intrinsic resistance to rapamycin.
Data show that H2O2 increased eIF4E (zeige EIF4E Antikörper) and 4E-BP1 (zeige EIF4EBP1 Antikörper) expression and eIF4E (zeige EIF4E Antikörper) phosphorylation, and shifted distribution of 4E-BP1 (zeige EIF4EBP1 Antikörper) phosphorylation. These oxidant-mediated alterations occur in concert with changes in factors known to regulate translation kinetics.
PHAS-II, but not PHAS-III, contributes to the control of protein synthesis by insulin (zeige INS Antikörper)
The C-terminal His74-Glu89 region of 4EBP2 acts as an auxiliary function for the major binding of Y(X)4L -binding motif (Tyr54-Leu60) to eIF4E (zeige EIF4E Antikörper).
4E-BPs regulate the stress granule localization of eIF4E (zeige EIF4E Antikörper)
decreasing cap-dependent translation by expressing a constitutively active mutant of the translational repressor eukaryotic initiation factor 4E-binding protein (zeige EIF4EBP1 Antikörper) 1 (4E-BP1 (zeige EIF4EBP1 Antikörper)) prevents neuronal misplacement and soma enlargement, while partially rescuing dendritic hypertrophy induced by hyperactive mTORC1.
data identify SH2B1 (zeige SH2B1 Antikörper) as a major regulator of IRS2 (zeige IRS2 Antikörper) stability, demonstrate a novel feedback mechanism linking mTORC1 signaling with IRS2 (zeige IRS2 Antikörper), and identify 4E-BP2 as a major regulator of proliferation and survival of beta-cells.
Data show that deletion of eukaryotic translation initiation factor 4E-binding protein 1/2 (4E-BP1/2) in erythroid cells rendered them resistant to mammalian target of rapamycin complex 1 (TORC1) inhibition and restored hemoglobin production.
Disruption of genes encoding Eif4ebp1 (zeige EIF4EBP1 Antikörper) and Eif4ebp2 does not alter basal or sepsis-induced changes in skeletal muscle protein synthesis in male or female mice.
4E-BP1 (zeige EIF4EBP1 Antikörper)/2-null cells express less ATGL (zeige PNPLA2 Antikörper) and accumulate more fat than control cells, while knock down of Egr1 (zeige EGR1 Antikörper) in 4E-BP1 (zeige EIF4EBP1 Antikörper)/2-null cells increases ATGL (zeige PNPLA2 Antikörper) expression and decreases fat storage.
translational control through 4E-BP2 represents a unique mechanism for selective regulation of AMPAR synthesis, synaptic function, and long-term plasticity, important for hippocampal-dependent memory processes.
in the absence of 4E-BP proteins, mTORC1-mediated phosphorylation of p70S6K1 (zeige RPS6KB1 Antikörper) is elevated by a reduction in competition between the two substrates for interaction with raptor (zeige RPTOR Antikörper)
Two deamidation sites were mapped to an asparagine-rich sequence unique to 4E-BP2. Deamidated 4E-BP2 exhibits increased binding to the mammalian target of rapamycin (mTOR (zeige FRAP1 Antikörper))-binding protein raptor (zeige RPTOR Antikörper).
These results, together with the fact that 4E-BPs are markedly induced during granulo-monocytic differentiation of myeloid cells in vitro, highlight the pivotal role of 4E-BP1 (zeige EIF4EBP1 Antikörper) and 4E-BP2 in the early phases of myelopoiesis
This gene encodes a member of the eukaryotic translation initiation factor 4E binding protein family. The gene products of this family bind eIF4E and inhibit translation initiation. However, insulin and other growth factors can release this inhibition via a phosphorylation-dependent disruption of their binding to eIF4E. Regulation of protein production through these gene products have been implicated in cell proliferation, cell differentiation and viral infection.
eukaryotic translation initiation factor 4E binding protein 2
, eukaryotic translation initiation factor 4E-binding protein 2
, eukaryotic initiation factor 4E
, eukaryotic translation initiation factor 4E
, eIF4E-binding protein 2
, phosphorylated, heat and acid stable regulated by insulin protein II
, phosphorylated heat- and acid-stable protein regulated by insulin 2