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EBI3 was identified by its induced expression in B lymphocytes in response Epstein-Barr virus infection. Zusätzlich bieten wir Ihnen EBI3 Antikörper (142) und EBI3 Kits (20) und viele weitere Produktgruppen zu diesem Protein an.
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Human EBI3 Protein expressed in Wheat germ - ABIN3013374
Guttek, Reinhold: Stimulated human peripheral T cells produce high amounts of IL-35 protein in a proliferation-dependent manner. in Cytokine 2013
Human EBI3 Protein expressed in CHO Cells - ABIN2719909
Wang, Wei, Xiao, Liu, Zhang, Han, Chen, Hou, Ma, Shen, Li, Egwuagu, Wang: A novel IL-23p19/Ebi3 (IL-39) cytokine mediates inflammation in Lupus-like mice. in European journal of immunology 2016
IL-35 is a relatively newly discovered member of the IL-12 (zeige IL12A Proteine) family which are unique in structure as they are dimer formed by two subunits; recent findings have shown abnormal expression of IL-35 in inflammatory autoimmune diseases and functional analysis suggested that IL-35 is critical in the onset and development of these diseases. [Review]
Pancreatic ductal carcinoma cells produce IL35 to recruit monocytes via CCL5 (zeige CCL5 Proteine) and induce macrophage to promote angiogenesis via expression of CXCL1 (zeige CXCL1 Proteine) and CXCL8 (zeige IL8 Proteine).
The plasma levels of interleukin-35 were significantly higher in the hepatocellular carcinoma patients than the controls.
over-expression of EBI3 could reduce the apoptosis of Treg/CD4 (zeige CD4 Proteine)(+)T/CD8 (zeige CD8A Proteine)(+)T cells and prevent radiation-induced immunosuppression of cervical cancer HeLa cells by inhibiting the activation of PD-1 (zeige PDCD1 Proteine)/PD-L1 (zeige CD274 Proteine) signaling pathway
Data show that interleukin-35 (Epstein-Barr virus-induced gene 3 (EBI3) and the interleukin-12 Subunit p35 (p35) subunit) levels were significantly elevated in the patients with influenza infection.
IL-35 was elevated in bone marrow of adult AML (zeige RUNX1 Proteine) patients and this increase was correlated with the clinical stages of malignancy, suggesting that IL-35 is involved in pathogenesis of AML (zeige RUNX1 Proteine).
Data suggest that the toll like receptor 3 (TLR3 (zeige TLR3 Proteine))-interferon regulatory factor 6 (zeige IRF6 Proteine) protein (IRF6 (zeige IRF6 Proteine))-interleukin-23 subunit p19 (p19 (zeige IL23A Proteine))/EBI3 protein axis may regulate keratinocyte functions in the skin.
EBI3 gene rs4740 polymorphism is closely associated wit (zeige SLC11A1 Proteine)h susceptibility to pulmonary tuberculosis and the elevation and enrichment of EBI3 in the lung derived from macrophages may contribute to the exacerbation of mycobacterial infection.
EBI3 Downregulation Contributes to Type I Collagen Overexpression in Scleroderma Skin.
IL-35 can effectively suppress the proliferation and IL-4 (zeige IL4 Proteine) production of activated CD4 (zeige CD4 Proteine)+CD25 (zeige IL2RA Proteine)- T cells in allergic asthma, and that IL-35 may be a new immunotherapy for asthma patients.
Data indicate an increase in the intracellular Epstein-Barr virus-induced 3 (EBI3) protein level in splenic NK cells during mouse cytomegalovirus (MCMV) infection.
IL-35-transduced adipocyte-derived mesenchymal stem cells in vivo can enhance proliferation of CD4 (zeige CD4 Proteine)(+) CD25 (zeige IL2RA Proteine)(+) Treg cells and suppress the function of effector T cells such as T helper (Th) 1 (zeige TH1L Proteine), Th2 and Th17 cells and may reduce the development of allograft rejection.
we describe here a new IL-12 member IL-39 (IL-23p19/Ebi3) secreted by activated B cells that mediate inflammatory responses in lupus-like mice. Thus, IL-39 might contribute to immunopathogenic mechanisms of SLE.
EBI3 can mediate IL-6 trans-signaling in a process that involves gp130
Data show that interleukin-35 (Epstein-Barr virus-induced gene 3 (EBI3) and the interleukin-12 Subunit p35 (p35) subunit) expressing plasmid downregulates the expression of pro-inflammatory cytokines and upregulates the expression of anti-inflammatory cytokines.
IL-35 treatment reduced collagen-induced arthritis via inhibiting vascular endothelial growth factor (zeige VEGF Proteine) and its receptors
Data suggest that interleukin-35 (Epstein-Barr virus-induced gene 3 (EBI3) and the interleukin-12 Subunit p35 (p35) subunit) contributes to the increased susceptibility to secondary pneumococcal pneumonia.
our results demonstrate that EBI3 is an essential general regulator of inflammatory immune responses in experimental Chagas disease
Report higher EBI3 expression in the lung tissue of BCG (zeige SLC11A1 Proteine)-infected mice.
This gene was identified by its induced expression in B lymphocytes in response Epstein-Barr virus infection. It encodes a secreted glycoprotein belonging to the hematopoietin receptor family, and heterodimerizes with a 28 kDa protein to form interleukin 27 (IL-27). IL-27 regulates T cell and inflammatory responses, in part by activating the Jak/STAT pathway of CD4+ T cells.
EBV-induced gene 3 protein
, Epstein-Barr virus induced gene 3
, IL-27 subunit beta
, IL27 subunit
, IL35 subunit
, cytokine receptor
, epstein-Barr virus-induced gene 3 protein
, interleukin-27 subunit beta
, Epstein-Barr virus induced 3
, interleukin 27 receptor beta
, epstein-Barr virus-induced gene 3 protein homolog
, Epstein-Barr virus induced gene 3 (similar to Interleukin-27 beta chain precursor)