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In the process of mRNA degradation, seems to play a role in mRNA decapping (By similarity). Zusätzlich bieten wir Ihnen EDC4 Antikörper (33) und EDC4 Kits (3) und viele weitere Produktgruppen zu diesem Protein an.
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Data suggest that specific motifs, secondary energy, and GC content of transcripts could play a role in their degradation by exoribonuclease4 (xrn4) and varicose (vcs).
Seedling lethal phenotypes in dcp1 (zeige ACE Proteine), dcp2 (zeige DCP2 Proteine) and vcs mutants are caused the disruption of miRNA-mediated gene regulation.
DCP2 (zeige DCP2 Proteine) interacts in vitro and in vivo with DCP1 (zeige ACE Proteine) and VARICOSE (VCS), an Arabidopsis homolog of human Hedls/Ge-1, suggesting that the three proteins operate as a decapping complex.
EDC4 plays a key role in homologous recombination by stimulating end resection at double-strand breaks.
The assembly of EDC4 and Dcp1a (zeige DCP1A Proteine) into processing bodies is critical for the translational regulation of IL-6 (zeige IL6 Proteine).
LMKB is the first protein identified to date that interacts with this portion of Ge-1. LMKB was expressed in human B and T lymphocyte cell lines; depletion of LMKB increased expression of IFI44L (zeige IFI44L Proteine).
EDC4 is a processing body (P-body) component.
The data indicates that DCP2 (zeige DCP2 Proteine) activation by DCP1 (zeige ACE Proteine) occurs preferentially on the EDC4 scaffold, which may serve to couple DCP2 (zeige DCP2 Proteine) activation by DCP1 (zeige ACE Proteine) with 5'-to-3' mRNA degradation by XRN1 (zeige XRN1 Proteine) in human cells.
EDC4 might contribute to regulation of CoA biosynthesis in addition to its scaffold function in processing bodies
Ge-1, the human ortholog of mouse Edc4, was shown to localize to mRNA processing bodies (P-body)in a human cell line. The C-terminal region is required for this localization.
The human Ge-1 gene (also known as Hedls and Edc4)is an ortholog of mouse Edc4. The gene was identified by screening a cDNA expression library using serum from a patient with Sjogren's syndrome.
In the process of mRNA degradation, seems to play a role in mRNA decapping (By similarity).
enhancer of mRNA decapping 4
, autoantigen Ge-1
, autoantigen RCD-8
, enhancer of mRNA-decapping protein 4
, human enhancer of decapping large subunit
, autoantigen RCD8