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EDC3 is associated with an mRNA-decapping complex required for removal of the 5-prime cap from mRNA prior to its degradation from the 5-prime end (Fenger-Gron et al., 2005 [PubMed 16364915]).[supplied by OMIM, Mar 2008]..
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The modular architecture enables enhancer of decapping 3 (EDC3) to interact with multiple components of the decapping (zeige ACE Proteine) machi (zeige DCP2 Proteine)nery, inclu (zeige DDX6 Proteine)ding DCP1, DCP2, and Me31B.
Tral (zeige LSM14A Proteine) and EDC3 specifically interact with the decapping activator DCP1 (zeige ACE Proteine) and the DEAD-box helicase Me31B (zeige DDX6 Proteine), in Drosophila cells.
In vitro decapping assays showed that altered EDC3 is unable to enhance DCP2 (zeige DCP2 Proteine) decapping at low concentrations and even inhibits DCP2 (zeige DCP2 Proteine) decapping at high concentration.
The modular architecture enables EDC3 to interact with multiple components of the decapping machinery, including DCP1 (zeige ACE Proteine), DCP2 (zeige DCP2 Proteine), and Me31B (zeige DDX6 Proteine).
The dimerization interface of Edc3 is highly conserved in eukaryotes despite the overall low sequence homology across species; structure-based site-directed mutagenesis revealed dimerization is required for efficient RNA binding, P-body formation
Structural basis for the mutually exclusive anchoring of P body components EDC3 and Tral (zeige LSM14A Proteine) to the DEAD box protein (zeige INTS6 Proteine) DDX6/Me31B (zeige DDX6 Proteine).
Induction of 14-3-3 (zeige YWHAQ Proteine) binding to EDC3 causes morphological changes in processing body structures, inhibition of microRNA-mediated mRNA post-transcriptional regulation, and alterations in the protein- protein interactions of EDC3.
EDC3 is associated with an mRNA-decapping complex required for removal of the 5-prime cap from mRNA prior to its degradation from the 5-prime end (Fenger-Gron et al., 2005
LSM16 homolog (EDC3, S. cerevisiae)
, enhancer of decapping 3
, enhancer of decapping-3
, enhancer of mRNA decapping 3 homolog
, enhancer of mRNA-decapping protein 3
, yjeF domain-containing protein 1
, yjeF N-terminal domain-containing protein 2
, yjeF domain containing
, LSM16 protein homolog