Elastase, Neutrophil Expressed Proteine (ELANE)

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Zusätzlich bieten wir Ihnen Elastase, Neutrophil Expressed Antikörper (178) und Elastase, Neutrophil Expressed Kits (106) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
ELANE 1991 P08246
ELANE 50701 Q3UP87
Ratte ELANE ELANE 299606  
Direkt bei antikoerper-online bestellen
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Online bestellen
  • orders@antikoerper-online.de

Top Elastase, Neutrophil Expressed Proteine auf antikoerper-online.de

Showing 10 out of 15 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$5,960.83
Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$5,960.83
Details
Human Human Unkonjugiert 10 μg Anmelden zum Anzeigen 6 bis 7 Tage
$109.63
Details
Escherichia coli (E. coli) Human His tag,GST tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$480.00
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
Details
Human Human Unkonjugiert   200 μg Anmelden zum Anzeigen 6 bis 7 Tage
$843.33
Details
Human Human Unkonjugiert   0.1 mg Anmelden zum Anzeigen 2 bis 3 Tage
$487.30
Details
Human Cells Human Unkonjugiert   25 μg Anmelden zum Anzeigen 11 bis 12 Tage
$460.00
Details
Escherichia coli (E. coli) Human Unkonjugiert   100 μg Anmelden zum Anzeigen 11 bis 18 Tage
$497.47
Details
Human Unkonjugiert   100 μg Anmelden zum Anzeigen 5 bis 6 Tage
$233.12
Details

ELANE Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , ,
, ,
Mouse (Murine)

Weitere Proteine zu Elastase, Neutrophil Expressed (ELANE) Interaktionspartnern

Human Elastase, Neutrophil Expressed (ELANE) Interaktionspartner

  1. Plasma Neutrophil Elastase and Elafin (zeige PI3 Proteine) as Prognostic Biomarker for Acute Respiratory Distress Syndrome.

  2. Our results suggest that associated serum levels of proMMP-9, NGAL (zeige LCN2 Proteine), proMMP-9/NGAL (zeige LCN2 Proteine) and NE may reflect the state of systemic inflammation in chronic obstructive pulmonary disease related to cigarette smoking.

  3. Using different blood leukocyte and skin resident cell preparations, and recombinant proteins, the authors have identified that neutrophil elastase, but not other neutrophil derived proteases, cleaves IL-36Ra into its highly active antagonistic form.

  4. Taken together, these observations support that the unusual HNE N-glycosylation, here reported for the first time, is involved in modulating multiple immune functions central to inflammation and infection.

  5. The role of neutrophil elastase in the activation of unfolded protein response effector molecules via PERK (zeige EIF2AK3 Proteine) and CHOP (zeige DDIT3 Proteine) is reported.

  6. results suggest activation of elastase in tendinopathy of the long head of the biceps increases the degradation of elastin (zeige ELN Proteine) to increase the levels of elastase, becoming a vicious cycle to the progressive severity of tendinopathy

  7. Coincubation with the inhibitors, particularly MK0339, promoted cell survival and increased formation of mature neutrophils. These studies suggest that cell-permeable inhibitors of neutrophil elastase show promise as novel therapies for ELANE-associated neutropenia.

  8. Data suggest that neuropilin-1 (NRP1 (zeige NRP1 Proteine)) functions as a receptor for neutrophil elastase (NE), mediates uptake/absorption of NE, and facilitates cross-presentation of PR1 (zeige TMEM37 Proteine) (a peptide fragment of NE) in breast cancer cells.

  9. This study proposes that acquisition of CSF3R (zeige CSF3R Proteine) mutations may represent a mechanism by which myeloid precursor cells carrying the ELANE mutations evade the proapoptotic activity of the Neutrophil Elastase mutants in SCN (zeige SRI Proteine) patients.

  10. Faecal biomarkers lactoferrin (zeige LTF Proteine), calprotectin (zeige S100A8 Proteine), and PMN-elastase were able to distinguish between ulcerative colitis patients with mucosal healing from clinical remission and mild disease, showed significant correlations with endoscopy, and were predictive of a flare.

Mouse (Murine) Elastase, Neutrophil Expressed (ELANE) Interaktionspartner

  1. Levels of neutrophil elastase (NE) and the nuclear factors CCAAT/enhancer-binding protein alpha (C/EBPalpha (zeige CEBPA Proteine)) and growth factor-independent 1 (GFI-1) are elevated in hematopoietic stem and progenitor cells from high-fat diet (HFD)-fed mice, but mice lacking either NE or C/EBPalpha (zeige CEBPA Proteine) are resistant to HFD-induced myelopoiesis.

  2. Sivelestat treatment significantly reduced the protein level, neutrophil count, neutrophil elastase activity in bronchoalveolar lavage fluid (BALF).

  3. Serine protease (zeige F2 Proteine) required for resistance to microbial infection; contributes to pathogenessis in endotoxic shock

  4. Neutrophils from neutrophil elastase-deficient mice show no defect in transendothelial migration

  5. results of ultrasound studies using the elastase and AngII apoE (zeige APOE Proteine) in 4 biomechanical parameters: aneurysm diameter, aneurysm volume, circumferential cyclic strain, and blood flow velocity

  6. Sirtinol is a novel HNE inhibitor and may have the potential for clinical application in the treatment of inflammatory lung diseases.

  7. SerpinA3N (zeige SERPINA3N Proteine) attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase

  8. Increased ELANE activity was associated with development of autoimmune diabetes mellitus in NOD mice.

  9. Neutrophil elastase is involved in the induction of microbicidal activities of neutrophils against Trypanosoma cruzi-infected macrophages.

  10. In conclusion, sivelestat reduced radiationinduced lung injury in the mice by suppressing neutrophil elastase activity and excessive inflammatory reactions

Elastase, Neutrophil Expressed (ELANE) Protein Überblick

Protein Überblick

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation.

Genbezeichner und Symbole assoziert mit ELANE

  • elastase, neutrophil expressed (ELANE)
  • elastase, neutrophil expressed (Elane)
  • proteinase 3 (prtn3)
  • ela2 Protein
  • ELANE Protein
  • F430011M15Rik Protein
  • GE Protein
  • HLE Protein
  • HNE Protein
  • NE Protein
  • PMN-E Protein
  • SCN1 Protein

Bezeichner auf Proteinebene für ELANE

PMN elastase , bone marrow serine protease , elastase 2, neutrophil , elastase-2 , granulocyte-derived elastase , human leukocyte elastase , leukocyte elastase , medullasin , neutrophil elastase , polymorphonuclear elastase , serine protease , elastase, neutrophil expressed , LOW QUALITY PROTEIN: neutrophil elastase

GENE ID SPEZIES
1991 Homo sapiens
50701 Mus musculus
299606 Rattus norvegicus
442980 Canis lupus familiaris
448597 Xenopus (Silurana) tropicalis
721134 Macaca mulatta
749897 Pan troglodytes
100126050 Bos taurus
100301482 Felis catus
100724414 Cavia porcellus
100522182 Sus scrofa
102173292 Capra hircus
101110841 Ovis aries musimon
Ausgewählte Anbieter für Elastase, Neutrophil Expressed Proteine (ELANE)
Haben Sie etwas anderes gesucht?