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The protein encoded by ELAC2 has a C-terminal domain with tRNA 3' processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. Zusätzlich bieten wir Ihnen ElaC Homolog 2 (E. Coli) Antikörper (54) und und viele weitere Produktgruppen zu diesem Protein an.
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This study describes the cardiac phenotype and outcome of ELAC2 mutation in Infantile Cardiomyopathy
ELAC2 rs11545302 polymorphism was associated with PSA > 20 and rs4792311 was associated with TNM > 2.
A homozygous splicing mutation in ELAC2 suggests phenotypic variability including intellectual disability with minimal cardiac involvement
ELAC2 mutations cause a mitochondrial RNA processing defect associated with hypertrophic cardiomyopathy.
results indicate that ELAC2 functions as a tRNase Z in human mitochondria and suggest that mt-tRNase Z preferentially cleaves molecules already processed by the proteinaceous mtRNase P
ELAC2 and PTCD1 affect the 3' end processing of tRNAs.
analysis of dual nuclear/mitochondrial targeting of the ELAC2 gene product by alternative translation initiation
Data describe polymorphisms in the HPC/ELAC-2 and alpha 1-antitrypsin genes that correlate with human diseases in an Indian population.
ELAC2 polymorphisms are associated with prostate cancer.
Our findings corroborate the involvement of ELAC2, MSR1, and RNASEL in the etiology of prostate cancer even in individuals without a family history.
variation in the putative prostate cancer susceptibility gene ELAC2 contributes to the elevated risk of prostate cancer in Afro-Caribbean males from Tobago
Meta-analysis of associations of the Ser217Leu and Ala541Thr variants in ELAC2 (HPC2) and prostate cancer
Although the Leu217 and Thr541 variants of ELAC2 are less common in Japanese than in Caucasians, both variants confer significantly increased risk of prostate cancer in Japanese.
ELAC2 interacts with the gamma-tubulin complex and perturbation of ELAC2 might promote tumorigenesis through irregular cell division
There is no evidence that either ELAC2 polymorphism is associated with prostate cancer or PSA level.
polymorphism of the ELAC2 gene is associated with prostatic cancer risk in Japanese men
When considering joint genotypes, white men homozygous for the Leu217 variant on an Ala541/Ala541 background had an increased risk of prostate cancer [odds ratio (OR)=1.84; 95% confidence interval (CI), 1.11-3.06].
ELAC2 has a role in prostate cancer
Thr allele at 541 in HPC2/ELAC2 has strong significance in the predisposition of sporadic Pca in Japan.
Single nucleotide polymorphisms associated with hereditary prostate cancer.
The protein encoded by this gene has a C-terminal domain with tRNA 3' processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
RNase Z 2
, elaC homolog protein 2
, ribonuclease Z 2
, tRNA 3 endonuclease 2
, tRNase Z 2
, tRNase Z(L)
, zinc phosphodiesterase ELAC protein 2
, elaC homolog 2
, heredity prostate cancer protein 2
, putative prostate cancer susceptibility protein HPC2/ELAC2
, tRNase Z (long form)