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Tissue-specific component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. Zusätzlich bieten wir Ihnen EID3 Antikörper (24) und viele weitere Produktgruppen zu diesem Protein an.
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Knockdown of EID3 by specific shRNA attenuated BMS-345541 -induced radiosensitization in MCF-7 cells.
These findings indicated a novel mechanism by which EID3, a p300 acetyltransferase inhibitor, could directly affect DNMT3A, this enzyme possesses dual methylation and demethylation abilities.
EID3 acts as an inhibitor of CBP/p300-dependent transcription in a tissue-specific manner.
Tissue-specific component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components (By similarity). Act as a repressor of nuclear receptor-dependent transcription possibly by interfering with CREBBP-dependent coactivation. May function as a coinhibitor of other CREBBP/EP300- dependent transcription factors (By similarity).
E1A-like inhibitor of differentiation 3
, EID-1-like inhibitor of differentiation 3
, EP300-interacting inhibitor of differentiation 3
, non-SMC element 4 homolog B
, non-structural maintenance of chromosomes element 4 homolog B