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DEF6, or IBP, is a guanine nucleotide exchange factor (GEF) for RAC (MIM 602048) and CDC42 (MIM 116952) that is highly expressed in B and T cells (Gupta et al., 2003 [PubMed 12923183]).[supplied by OMIM, Mar 2008].. Zusätzlich bieten wir Ihnen DEF6 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
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Human Monoclonal DEF6 Primary Antibody für IHC (p), IP - ABIN565491
Worthmann, Leitges, Teng, Sestu, Tossidou, Samson, Haller, Huber, Schiffer: Def-6, a novel regulator of small GTPases in podocytes, acts downstream of atypical protein kinase C (aPKC) ?/?. in The American journal of pathology 2013
Show all 2 Pubmed References
Human Polyclonal DEF6 Primary Antibody für ELISA, WB - ABIN268577
Tanaka, Bi, Kitamura, Hong, Altman, Matsumoto, Tabata, Lebedeva, Bushway, Altman: SWAP-70-like adapter of T cells, an adapter protein that regulates early TCR-initiated signaling in Th2 lineage cells. in Immunity 2003
Swap70b and Def6a delineate Wnt11 (zeige WNT11 Antikörper) and Wnt5b (zeige WNT5B Antikörper) signalling pathways and have roles in convergent and extension cell movement during zebrafish gastrulation
def6 morphants phenocopy Wnt5b (zeige WNT5B Antikörper) mutants and ectopic overexpression of def6 essentially rescues Wnt5b (zeige WNT5B Antikörper) morphants, indicating a novel role for def6 as a central GEF (zeige SLC2A4RG Antikörper) downstream of Wnt5b (zeige WNT5B Antikörper) signaling
Studies indicate that the autoimmune phenotype in DEF6 and SWAP-70 knock-out (DKO) mice is characterized by the accumulation of B cell subset that expresses high levels of CD11c and T-bet (ABCs).
DEF6 and SWAP70 (zeige SWAP70 Antikörper) are SWEF proteins with important contributors to hematopoietic stem and precursor cells biology
this study identifies Def6 as a novel inhibitor of osteoclastogenesis in physiological and inflammatory conditions
These findings ascribe a new function to SLAT, and identify Rap1 as a target of SLAT function in TCR-mediated inside-out signaling.
SLAT is an IP3R1 (zeige ITPR1 Antikörper)-interacting protein required for T cell activation.
PKClambda/iota was identified as an important factor for actin cytoskeletal regulation in podocytes and Def-6 as a specific downstream target of PKClambda/iota that regulates the activity of small GTPases and subsequently the actin cytoskeleton of podocytes.
Data suggest that SLAT acts as a negative modulator of RANKL (zeige TNFSF11 Antikörper)-induced osteoclastogenesis.
SLAT-mediated nuclear factor of activated T-cell (zeige NFATC3 Antikörper) (NFAT)1 (zeige NFAT1 Antikörper) activation is required for efficient expansion of CD8 (zeige CD8A Antikörper)+ T cells during the primary response but is not necessary for cytotoxic T lymphocyte (CTL) differentiation.
SLAT/Def6 plays a major role in the T cell-mediated autoimmune processes that bring about the inflammatory eye disease, experimental autoimmune uveitis.
plays a role in Th2 development and/or activation, perhaps by interfering with ZAP-70 (zeige ZAP70 Antikörper) signaling
this study identifies Def6 (zeige DEFA6 Antikörper) as a novel inhibitor of osteoclastogenesis in physiological and inflammatory conditions
DEF6 expression may serve as an independent prognostic factor, and interacted positively with p16 toward high tumor stage and shorter survival.
IBP (zeige TSPO Antikörper) was expressed ectopically in someoral squamous cell carcinoma samples and correlated significantly with tumor size, differentiation, clinical stage and distant metastases
DEF6 (zeige DEFA6 Antikörper), a novel substrate for the Tec (zeige NR4A3 Antikörper) kinase ITK (zeige ITK Antikörper), contains a glutamine (zeige GFPT1 Antikörper)-rich aggregation-prone region and forms cytoplasmic granules that co-localize with P-bodies.
Molecular cloning of IBP (zeige TSPO Antikörper), a guanine nucleotide exchange factor (zeige RASGRF1 Antikörper), which is highly expressed in the immune system.
IBP (zeige TSPO Antikörper) is a novel guanine nucleotide exchange factor (zeige RASGRF1 Antikörper) and is recruited to the immunological synapse by T cell receptor engagement
DEF6 not only activates Rho-family GTPases but also cooperates with activated Rac1 to exert its cellular function
Overexpression of the Interferon regulatory factor 4 (zeige IRF4 Antikörper)-binding protein is associated with Colorectal Carcinoma.
DEF6 (zeige DEFA6 Antikörper), a novel PH-DH-like domain protein, is an upstream activator of the Rho GTPases Rac1, Cdc42 (zeige CDC42 Antikörper), and RhoA (zeige RHOA Antikörper).
DEF6, or IBP, is a guanine nucleotide exchange factor (GEF) for RAC (MIM 602048) and CDC42 (MIM 116952) that is highly expressed in B and T cells (Gupta et al., 2003
differentially expressed in FDCP 6 homolog (mouse)
, differentially expressed in FDCP 6 homolog
, IRF-4-binding protein
, IRF4-binding protein
, SWAP-70-like adapter of T-cells
, SWAP-70-like adaptor protein of T cells