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DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Zusätzlich bieten wir Ihnen DNA (Cytosine-5)-Methyltransferase 1 Antikörper (488) und DNA (Cytosine-5)-Methyltransferase 1 Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.
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Qin, Leonhardt, Pichler: Regulation of DNA methyltransferase 1 by interactions and modifications. in Nucleus (Austin, Tex.) 2011
Dnmt1 stability requires UHRF1 phosphorylation and that crosstalk between the proteins is essential for the function of these two important epigenetic regulators during gastrulation
Lsh Is Essential for Maintaining Global DNA Methylation Levels in Amphibia and Fish and Interacts Directly with Dnmt1.
Dnmt1 is required for hematopoietic stem and progenitor cells maintenance via cebpa (zeige CEBPA ELISA Kits) regulation during definitive hematopoiesis in zebrafish
These data provide the first evidence that Uhrf1 and Dnmt1 function is required for vertebrate lens development and maintenance.
These results suggest that Dnmt1 activity helps direct histone methylation by Suv39h1 and that, together, Dnmt1 and Suv39h1 help guide the terminal differentiation of particular tissues.
Data show that in dnmt1 homozygous mutants, reactivation of gfp expression occurs in a reproducible subset of cells, raising the possibility of different sensitivities or alternative silencing mechanisms in discrete cell populations.
Thus, our data suggest that Dnmt1 is dispensable for pancreatic duct or endocrine cell formation, but not for acinar cell survival. In addition, Dnmt1 may influence the differentiation of pancreatic beta cell progenitors.
PRIMA-1 could cause the demethylation of TP73 (zeige TP73 ELISA Kits), through DNMT1 depletion, to subsequently enhance the unfolded protein response
Results show that DNMT1 is highly expressed in lung tumors compared to normal tissues, and that DBCCR1 attenuates its expression suggesting a reciprocal regulation between genetic silencing of cancer suppressor genes and activating DNA methylation.
A decreased expression of anti-DNMT1 miRNAs might account for azacitidine resistance in higher-risk myelodysplastic syndrome and acute myeloid leukemia (zeige BCL11A ELISA Kits) , and measuring miRNA expression before and during treatment might help predict primary or secondary azacitidine resistance
these findings revealed that miR (zeige MLXIP ELISA Kits)-217 promotes fibroblasts senescence by suppressing DNMT1-mediated methylation of p16 and pRb (zeige RB1 ELISA Kits) by targeting the DNMT1 3'-UTR (zeige UTS2R ELISA Kits).
Ultraviolet B rays suppressed SIRT1 (zeige SIRT1 ELISA Kits) expression by activating AhR (zeige AHR ELISA Kits), and subsequently inhibited DNMT1 activity in CD4 (zeige CD4 ELISA Kits)+ T cells from systemic lupus erythematosus patients.
DNMT1 expression is increased in low-grade gliomas and is associated with improved survival. Its expression is regulated by phosphorylated c-Jun and correlates with high DNA methylation.
in patents with chronic hepatitis B, data showed a DNMT1 overexpression significantly correlated to nucleo(t)side analogs (NA) therapy duration and higher regional mitochondrial DNA hypermethylation; this might suggest an epigenetic alteration that could be involved in one of the possible mechanisms of mitochondrial gene regulation during NAs (zeige SCN9A ELISA Kits) therapy
The meta-analysis also suggested that DNMT1 rs16999593 (T/C) may be associated with gastric cancer, while rs2228611 (G/A) may be associated with breast cancer. In future research, large-scale and well-designed studies are required to verify these findings.
FQI1 mediates alteration of the tumor epigenome by DNMT1-LSF complex disruption, leading to aberrant DNA methylation and gene expression.
DNMT1-mediated transcriptional upregulation of IGF2 is a novel mechanism of resistance to HDIs, highlighting the role of epigenetic deregulation of IGF2 in HDI resistance and the potential value of the H19 (zeige NCKAP1 ELISA Kits)/IGF2 ICR hypermethylation and DNMT1 expression as predictive biomarkers in HDI-based anticancer therapies.
Dnmt1 was indispensable for oocyte cytoplasmic maturation, providing a novel role for Dnmt1 in the regulation of oocyte maturation.
Data show that the expression levels of the 5 epigenetic modifying genes Dnmt1, Dnmt3a, Hdac1, Kdm3a and Uhrf1 were higher in group pig in highland (TH) than in group Yorkshire in highland (YH).
DNMT1o is localized mainly in the nuclei of oocytes and early embryos, whereas DNMT1s is expressed in the ooplasm cortex of oocytes and cytoplasm of early embryos.
results indicate that loss of Dnmt1 in the maternal nucleus during SCNT significantly contributes to the unfaithful maintenance of methylation imprints in cloned embryos
Oocyte-specific Dnmt1 is cytoplasmic during early development.
Dnmt1 mRNA abundance plays an important role during protein regulation, Dnmt1 enzyme is mainly posttranscriptionally regulated.
DNMT1 silencing significantly decreased the methylation levels of miR (zeige MYLIP ELISA Kits)-29b promoter, up-regulated miR (zeige MYLIP ELISA Kits)-29b expression and inhibited bovine viral diarrhea virus replication.
Through down-regulating the expression of DNMT1, miR (zeige MYLIP ELISA Kits)-152 reduced Global DNA methylation and the activity of DNMT to reactivate the lactation signal transduction genes Akt (zeige AKT1 ELISA Kits) and Ppar gamma (zeige PPARG ELISA Kits).
More DNMT1 mRNA was detected in the transgenic somatic cell nuclear transfer (SCNT) group than the other three groups. Hsp 70.1 mRNA was detected in the in vitro fertilzation embryos. Mash2 (zeige ASCL2 ELISA Kits) mRNA was present at highest levels in transgenic SCNT embryos.
Our results indicate an essential role for Dnmt1 during bovine preimplantation development (zeige MTA2 ELISA Kits), and suggest proper transcriptional reprogramming of this gene family in SCNT embryos.
Dnmt1 is retained in the cytoplasm in metaphase II stage oocytes and zygotes, it enters the nuclei of 8-16 cell stage embryos
Abnormal gene expression of DNMT, INFT, and MHC1 was noted in the majority of cloned embryos, indicating inefficient nuclear reprogramming and retarded embryo development.
Results describe the alternative splicing and expression analysis of bovine DNA methyltransferase 1.
Report inhibition of DNA methyltransferase 1 expression in bovine fibroblast cells used for nuclear transfer.
Long-term stability and epigenetic features differ for individual loci. Our data show that over-expression of MET1, and potentially of other genes encoding epigenetic factors, offers an alternative strategy to identify epigenetic target genes and to create novel epi (zeige TFPI ELISA Kits)-alleles
MET1 confines ARID1 to the vegetative cell of male gametes, but ARID1 conversely represses MET1 in the central cell of female gametes.
MET1 is a thylakoid-associated TPR protein involved in photosystem II supercomplex formation and repair in Arabidopsis
Met1 gene expression throughout normal development, particularly in the flower
MET1 is a contributor to epigenetic diversity in Arabidopsis.
VIM (zeige VIM ELISA Kits) proteins regulate genome-wide epigenetic gene silencing through coordinated modulation of DNA methylation and histone modification status in collaboration with MET1
VIM proteins function in transcriptional regulation via their roles in the MET1 DNA methylation pathway.
Genetic studies indicate that the Polycomb Repressive Complex 2 (PRC2) but not the DNA METHYLTRANSFERASE1 (MET1) is involved in regulating imprinted expression in the embryo. [MET1]
MET1 restores body methylation, which is region-specific but random with respect to the affected CG sites, and is moderately although not decisively influenced by transcription.
There is a mechanistic link between two major epigenetic pathways involved in histone and DNA methylation in plants by physical interaction of MET1 with the FIS-PRC2 core component MEA.
Sp1 (zeige SP1 ELISA Kits)/NFkappaB p65 (zeige NFkBP65 ELISA Kits)-Dnmt1 pathway may be exploited as a therapeutic target for protecting against podocyte injury in diabetic nephropathy.
2-hydroxyglutarate bound to DNMT1 and stimulated its association with the RIP3 promoter, inducing hypermethylation that reduces RIP3 protein and consequently impaired RIP3-dependent necroptosis.
The results demonstrated that Islet1 (zeige ISL1 ELISA Kits) upregulated expression of general control of amino acid biosynthesis protein 5 (zeige CAPS ELISA Kits) (Gcn5) and enhanced the binding of Gcn5 to the promoters of GATA binding protein 4 (GATA4 (zeige GATA4 ELISA Kits)) and NK2 homeobox 5 (Nkx2.5 (zeige NKX2-5 ELISA Kits)). In addition, Islet-1 (zeige ISL1 ELISA Kits) downregulated DNA methyltransferase (DNMT)1 expression and reduced its binding to the GATA4 (zeige GATA4 ELISA Kits) promoter.
Data show that RGS6 (zeige RGS6 ELISA Kits) loss impairs p53 (zeige TP53 ELISA Kits) activation and promotes aberrant accumulation of oncogenic protein DNMT1 in urothelium.
Data (including data from studies using knockout/transgenic mice) suggest that neuronal Dnmt1 regulates energy homeostasis through pathways controlling energy homeostasis; here, neuronal Dnmt1 deficiency prevents diet-induced obesity, reduces adiposity, reduces food intake, and increases energy expenditure in male mice.
Deletion of DNmt1 in postnatal forebrain neurons results in anxiolytic and antidepressant-like responses.
Upon lysolecithin injection in the spinal cord of transgenic mice, study detected defective oligodendrocyte progenitor cells differentiation and inefficient remyelination in the DNA methyltransferase 3a (zeige DNMT3A ELISA Kits) null and DNA methyltransferase 1/DNA methyltransferase 3a (zeige DNMT3A ELISA Kits) null mice.
Data from studies using mouse embryonic fibroblasts suggest that cell proliferation rate positively correlates with expression of Dnmt1 in G1 phase; global DNA methylation is significantly higher in G1 phase than in G2/M phase; larger methylation differences are observed on promoters of pluripotency-related genes; thus, high cell proliferation rates promote generation of induced pluripotent stem cells.
Dnmt1 and Ezh2 (zeige EZH2 ELISA Kits) play distinct roles in the different islet cell types
we extended this work by using a biotinylation tagging approach to characterize DNMT1 protein complexes in mouse erythroleukemic cells. We identified novel DNMT1 interactions with several hematopoietic transcription factors with essential roles in erythroid differentiation
DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities. Two transcript variants encoding different isoforms have been found for this gene.
DNA (cytosine-5)-methyltransferase 1
, CXXC-type zinc finger protein 9
, DNA MTase HsaI
, DNA methyltransferase HsaI
, DNA methyltransferase 1
, DNA (cytosine 5 ) methyltransferase 1
, DNA methyltransferase (cytosine 5 ) methyltransferase
, DNA methyltransferase b
, DNA MTase RnoIP
, DNA methyltransferase (cytosine-5) 1
, DNA methyltransferase I
, DNA MTase GgaI
, DNA MeTase
, DNA methyltransferase GgaI
, DNA MTase MmuI
, DNA methyltransferase MmuI