DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58) ELISA Kits

Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Zusätzlich bieten wir Ihnen DHX58 Antikörper (104) und DHX58 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
DHX58 79132 Q96C10
DHX58 80861 Q99J87
DHX58 303538  
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Top DHX58 ELISA Kits auf antikoerper-online.de

Showing 10 out of 16 products:

Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Anbieter Lieferzeit Preis Details
Human 1.41 pg/mL 15.63-1000 pg/mL 96 Tests Anmelden zum Anzeigen 3 bis 4 Tage
$390.31
Details
Ratte 0.1 ng/mL 0.5-10 ng/mL   96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$707.14
Details
Maus 0.1 ng/mL 1.0-25 ng/mL   96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$707.14
Details
Meerschweinchen 0.1 ng/mL 1.0-25 ng/mL   96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$707.14
Details
Kaninchen 0.1 ng/mL 1.0-25 ng/mL   96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$707.14
Details
Affe 0.1 ng/mL 1.0-25 ng/mL   96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$707.14
Details
Hund 0.1 ng/mL 1.0-25 ng/mL   96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$707.14
Details
Huhn 0.094 ng/mL 0.156 ng/mL - 10 ng/mL   96 Tests Anmelden zum Anzeigen 11 bis 18 Tage
$724.89
Details
Schwein 0.094 ng/mL 0.156 ng/mL - 10 ng/mL   96 Tests Anmelden zum Anzeigen 11 bis 18 Tage
$724.89
Details
Schaf
  96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$707.14
Details

Weitere ELISA Kits für DHX58 Interaktionspartner

Rainbow Trout (Oncorhynchus mykiss) DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58) Interaktionspartner

  1. MDA5 (zeige IFIH1 ELISA Kits) and LGP2 act as independent positive regulators of the IFN response in fish. the LGP2 variant with a deletion of 54 amino acids at the C terminus acts as a negative regulator for LGP2-elicited antiviral signaling.

Human DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58) Interaktionspartner

  1. Results indicate that pumilio RNA binding family member 1 (PUM1) is a negative regulator of RNA helicase LGP2 (LGP2), a master regulator of innate immunity genes expressed in a cascade fashion.

  2. study documents that recombinant measles virus produce defective interfering genomes that have high immunostimulatory properties via their binding to RIG-I (zeige DDX58 ELISA Kits) and LGP2 proteins, both of which are cytosolic nonself RNA sensors of innate immunity.

  3. Data support a new model where an LGP2-MDA5 oligomer shuttles NS3 to the mitochondria to block antiviral signaling

  4. essential role in activating interferon (zeige IFNA ELISA Kits) signaling against hepatitis C virus (HCV) infection by promoting MDA5 (zeige IFIH1 ELISA Kits) recognition of HCV pathogen-associated molecular patterns

  5. This review briefly summarizes the RLR system, and focuses on the relationship between LGP2 and MDA5 (zeige IFIH1 ELISA Kits), describing in detail how these two proteins work together to detect foreign RNA and generate a fully functional antiviral response.

  6. L region antisense RNA of EMCV is a key determinant of innate immunity to the virus and represents an RNA that activates LGP2 associated MDA5 (zeige IFIH1 ELISA Kits) in virally-infected cells.

  7. LGP2 did not reveal significant single-SNP associations with multiple sclerosis risk.

  8. LGP2 increases the initial rate of MDA5 (zeige IFIH1 ELISA Kits)-RNA interaction and regulates MDA5 (zeige IFIH1 ELISA Kits) filament assembly.

  9. Experiments with paramyxovirus V protein-insensitive proteins revealed that the primary outcome of LGP2 interference is suppression of its ability to synergize with MDA5 (zeige IFIH1 ELISA Kits).

  10. Data show that LGP2 is able to synergize with melanoma differentiation associated gene-5 (mda-5 (zeige IFIH1 ELISA Kits)) to render cells to induction by poly(I:C), but did not enhance retinoic acid-inducible gene-I (RIG-I (zeige DDX58 ELISA Kits)) to induce type I interferon (zeige IFNA ELISA Kits) in response to poly(I:C).

Mouse (Murine) DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58) Interaktionspartner

  1. PACT interacts with LGP2 and this interaction is enhanced by encephalomyocarditis virus (EMCV) infection. In vitro interaction analyses using purified recombinant proteins confirmed that the single-stranded Theiler's murine encephalitis virus genome enhanced the interaction between LGP2 and PACT.

  2. L region antisense RNA of EMCV is a key determinant of innate immunity to the virus and represents an RNA that activates LGP2 associated MDA5 (zeige IFIH1 ELISA Kits) in virally-infected cells.

  3. This in vivo study reveals that LGP2 is a major downregulator of the influenza A virus-triggered detrimental inflammatory response.

  4. Enhanced expression of LGP2 suppresses the IFN stimulated genes associated with cytotoxic stress by turning off the expression of IFNbeta

  5. LGP2, a host protein induced during influenza A virus infection, downregulates the host antiviral IFN response

  6. LGP2 promotes an essential prosurvival signal in response to antigen stimulation to confer CD8 (zeige CD8A ELISA Kits)+ T cell-number expansion and effector functions against divergent RNA viruses, including West Nile virus and lymphocytic choriomeningitis virus.

  7. findings demonstrate a regulatory role for LGP2 in the response to cytosolic DNA, an intracellular bacterial pathogen, and a DNA virus, and provide a plausible mechanistic hypothesis as the basis for this activity

  8. data suggest that LGP2 facilitates viral RNA recognition by RIG-I (zeige DDX58 ELISA Kits) and MDA5 (zeige IFIH1 ELISA Kits) through its ATPase (zeige DNAH8 ELISA Kits) domain.

  9. Lgp2 acts as a negative feedback regulator of antiviral signaling by sequestering double-stranded RNA from retinoic acid-inducible gene-I (RIG-I (zeige DDX58 ELISA Kits)).

  10. Functional analysis of the human LGP2 ortholog.

Pig (Porcine) DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58) Interaktionspartner

  1. Study indicates that DHX58 is an important gene that is associated with the immune response in swine.

Cow (Bovine) DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58) Interaktionspartner

  1. Functional analysis of the human LGP2 ortholog.

DHX58 Antigen-Profil

Beschreibung des Gens

Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1- dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses, and also to the bacterial pathogen Listeria monocytogenes. Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5'-triphosphorylated RNA, although it can recognize RNA lacking a 5'-triphosphate.

Genbezeichner und Symbole assoziert mit DHX58

  • DEXH-box helicase 58 L homeolog (dhx58.L) Antikörper
  • DExH-box helicase 58 (DHX58) Antikörper
  • DExH-box helicase 58 (dhx58) Antikörper
  • probable ATP-dependent RNA helicase DHX58 (LOC100566102) Antikörper
  • DEXH (Asp-Glu-X-His) box polypeptide 58 (dhx58) Antikörper
  • DEXH (Asp-Glu-X-His) box polypeptide 58 (Dhx58) Antikörper
  • DEXH-box helicase 58 (Dhx58) Antikörper
  • B430001I08Rik Antikörper
  • D11LGP2 Antikörper
  • D11Lgp2e Antikörper
  • DHX58 Antikörper
  • Lgp2 Antikörper
  • LPG2 Antikörper
  • MGC82787 Antikörper
  • RGD1310093 Antikörper
  • RLR-3 Antikörper

Bezeichner auf Proteinebene für DHX58

DEXH (Asp-Glu-X-His) box polypeptide 58 , probable ATP-dependent RNA helicase DHX58 , probable ATP-dependent RNA helicase DHX58-like , Probable ATP-dependent RNA helicase DHX58 , RIG-I-like receptor 3 , RIG-I-like receptor LGP2 , RLR , RNA helicase LGP2 , ortholog of mouse D11lgp2 , probable ATP-dependent helicase LGP2 , protein D11Lgp2 homolog , RIG-I-like receptor Lgp2 , protein D11Lgp2 , ATP-dependent RNA helicase DHX58

GENE ID SPEZIES
444342 Xenopus laevis
742679 Pan troglodytes
100012544 Monodelphis domestica
100066316 Equus caballus
100171435 Pongo abelii
100403680 Callithrix jacchus
100468505 Ailuropoda melanoleuca
100499613 Oncorhynchus mykiss
100566102 Anolis carolinensis
100195148 Salmo salar
79132 Homo sapiens
80861 Mus musculus
303538 Rattus norvegicus
607803 Canis lupus familiaris
100524520 Sus scrofa
508378 Bos taurus
101121528 Ovis aries
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