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The protein encoded by CDKN3 belongs to the dual specificity protein phosphatase family.
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Human Polyclonal CDKN3 Primary Antibody für WB - ABIN1881194
Jiang, Xia, Li, Deng, Zhao, Shi, Wang, Sun: High expression levels of IKKalpha and IKKbeta are necessary for the malignant properties of liver cancer. in International journal of cancer. Journal international du cancer 2010
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Results demonstrate that upregulation of p27 (zeige PAK2 Antikörper) is involved in the knockdown of CDKN3-induced decrease in cell proliferation, increase in cell cycle arrest and apoptosis, decrease in invasion, and increase in radiosensitivity.
the mechanism of CDKN3 overexpression in human cancer
CDKN3 is frequently upregulated in gastric cancer tissues and cell lines and is related to advanced clinical stage, recurrence, and poor clinical outcome in gastric cancer. The functional data strongly suggest that CDKN3 behaves as an oncogene (zeige RAB1A Antikörper) in gastric cancer, and downregulation of CDKN3 could inhibit gastric cancer cell proliferation, migration, and invasion, and induce cell cycle arrest and apoptosis.
CDKN3 may act as a tumor suppressor in liver tissues by modulation of the cell survival signal transduction, monitoring carcinogenesis and elimination of abnormal cells.
These results suggest that CDKN3 acts as an oncogene (zeige RAB1A Antikörper) during breast cancer progression. The in vitro silencing of CDKN3 promoted apoptosis, induced G1 phase cell cycle arrest and inhibited cell migration.
Knockdown of Cdkn3 stabilizes Mps1 (zeige IDUA Antikörper) at centrosomes.
CDKN3 mRNA may be a good survival biomarker and potential therapeutic target in cervical cancer
CDKN3 overexpression in lung adenocarcinoma is not attributed to alternative splicing or mutation but is likely due to increased mitotic activity, arguing against CDKN3 as a tumour suppressor
CDKN3 knockdown reduces cell proliferation, invasion and promotes apoptosis in human ovarian cancer cells.
These results highlight the importance of CDKN3 in Bcr-Abl (zeige ABL1 Antikörper)-mediated leukemogenesis.
KRP3 role in gall maturation and root-knot (zeige KCNK7 Antikörper) nematode feeding
The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
CDK2-associated dual specificity phosphatase
, CDK2-associated dual-specificity phosphatase
, Cdk-associated protein phosphatase
, cyclin-dependent kinase interacting protein 2
, cyclin-dependent kinase interactor 1
, cyclin-dependent kinase-interacting protein 2
, kinase associated phosphatase
, kinase-associated phosphatase
, cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase)
, cyclin-dependent kinase inhibitor 3
, Kinase-associated phosphatase
, Inhibitor/interactor of CDK protein 6
, KIP-related protein 3