Cyclin M2 Proteine (CNNM2)

CNNM2 encodes a member of the ancient conserved domain containing protein family. Zusätzlich bieten wir Ihnen Cyclin M2 Antikörper (50) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
CNNM2 54805 Q9H8M5
CNNM2 94219 Q3TWN3
Ratte CNNM2 CNNM2 294014 Q5U2P1
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Showing 2 out of 6 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
Details

CNNM2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human
,
Mouse (Murine)
,

Weitere Proteine zu Cyclin M2 (CNNM2) Interaktionspartnern

Human Cyclin M2 (CNNM2) Interaktionspartner

  1. In this large-scale, Han Chinese population-based genetic association study for genetic susceptibility to schizophrenia of a three-gene cluster region, AS3MT (zeige AS3MT Proteine)-CNNM2-NT5C2 (zeige NT5C2 Proteine), two SNPs with independent effects, rs11191419 and rs11191514, were identified. Rs11191419 is located on the 5' (potential promoter) region of AS3MT (zeige AS3MT Proteine), while rs11191514 is located in one of the introns of CNNM2.

  2. this study implicates altered neural expression of BORCS7, AS3MT (zeige AS3MT Proteine), and NT5C2 (zeige NT5C2 Proteine) in susceptibility to schizophrenia arising from genetic variation at the chromosome 10q24 locus

  3. Sensitivity of CNNM2 expression to extracellular Mg(2 (zeige MUC7 Proteine)+) depletion depends on cell type.

  4. The T568I mutation causes the magnesium transporter, CNNM2, to become 'locked' in its flat form.

  5. Cells expressing mutated CNNM2 proteins did not show increased Mg(2 (zeige MUC7 Proteine)+) uptake.

  6. This CNNM2 risk variant rs7914558 may have an impact on neural systems relevant to social cognition.

  7. Our findings suggest that the genetic variant in the CNNM2 gene could be implicated in the pathogenesis of schizophrenia through the gray matter volumetric vulnerability of the orbital regions in the inferior frontal gyri.

  8. crystals of CNNM2 belonged to space groups P2(1)2(1)2 and I222 (or I2(1)2(1)2(1)) and diffracted X-rays to 2.0 and 3.6 A resolution, respectively, using synchrotron radiation

  9. analysis of structure of CNNM2 and its post-translational modifications

  10. ACDP2 splice-variant 1 is a functional Mg2 (zeige MUC7 Proteine)+-transporting entity per se.

Mouse (Murine) Cyclin M2 (CNNM2) Interaktionspartner

  1. we generated kidney-specific Cnnm2- deficient mice and clearly demonstrated that the CNNM2 function in the kidney is important in maintaining not only magnesium homeostasis but also blood pressure.

  2. data shed new light on the structural basis underlying the interaction between PRL (zeige PRL Proteine) phosphatases and CNNM transporters and provides a hypothesis about the molecular mechanism by which PRL-1 (zeige PTP4A1 Proteine), upon binding to CNNM2, might increase the intracellular concentration of Mg(2 (zeige MCOLN1 Proteine)+) thereby contributing to tumor progression and metastasis.

  3. Thus, sperm motility and Ca(2 (zeige CA2 Proteine)+) response were more severely affected in sperm from Cnnm2(+/Delta); Cnnm4 (zeige CNNM4 Proteine)(Delta/Delta) mice than in those from Cnnm4 (zeige CNNM4 Proteine)(Delta/Delta) mice, implicating CNNM2 in regulating these processes.

  4. analysis of structure of CNNM2 and its post-translational modifications

  5. ACDP2 may provide a regulated transporter for Mg2 (zeige MCOLN1 Proteine)+ and other divalent cations in epithelial ce

Cyclin M2 (CNNM2) Protein Überblick

Protein Überblick

This gene encodes a member of the ancient conserved domain containing protein family. Members of this protein family contain a cyclin box motif and have structural similarity to the cyclins. The encoded protein may play an important role in magnesium homeostasis by mediating the epithelial transport and renal reabsorption of Mg2+. Mutations in this gene are associated with renal hypomagnesemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Genbezeichner und Symbole assoziert mit Cyclin M2 Proteine (CNNM2)

  • cyclin and CBS domain divalent metal cation transport mediator 2 (CNNM2)
  • cyclin and CBS domain divalent metal cation transport mediator 2 (cnnm2)
  • metal transporter CNNM2 (LOC100059801)
  • cyclin M2 (Cnnm2)
  • cyclin and CBS domain divalent metal cation transport mediator 2 (Cnnm2)
  • Acdp2 Protein
  • acdp4 Protein
  • AU015877 Protein
  • AW048635 Protein
  • Clp2 Protein
  • cnnm4 Protein

Bezeichner auf Proteinebene für Cyclin M2 Proteine (CNNM2)

cyclin M2 , metal transporter CNNM4 , cyclin-M4 , ancient conserved domain-containing protein 4 , ancient conserved domain-containing protein 2 , metal transporter CNNM2 , ancient conserved domain protein 2 , cyclin-M2 , cyclin-like protein 2 , mACDP2

GENE ID SPEZIES
428975 Gallus gallus
450705 Pan troglodytes
100022652 Monodelphis domestica
100036645 Xenopus (Silurana) tropicalis
100059801 Equus caballus
100081019 Ornithorhynchus anatinus
100347338 Oryctolagus cuniculus
100440124 Pongo abelii
100484329 Ailuropoda melanoleuca
100540642 Meleagris gallopavo
100554221 Anolis carolinensis
100598160 Nomascus leucogenys
54805 Homo sapiens
94219 Mus musculus
294014 Rattus norvegicus
486866 Canis lupus familiaris
100155831 Sus scrofa
504632 Bos taurus
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