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The protein encoded by CNGA2 represents the alpha subunit of a cyclic nucleotide-gated olfactory channel. Zusätzlich bieten wir Ihnen Cyclic Nucleotide Gated Channel alpha 2 Antikörper (89) und viele weitere Produktgruppen zu diesem Protein an.
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Identification of a novel X-linked stop mutation in CNGA2 (c.634C>T, p.R212*) in two brothers with isolated congenital anosmia.
The results showed that it is predominantly the charge of the E342 residue in the P-loop, rather than the pore helix dipoles, which controls the cation-anion selectivity of the CNGA2 channel.
CNGA2 channels play a key role in adenosine-induced endothelial Ca(2 (zeige CA2 Proteine)+) influx and vasorelaxation
In Cnga2 knock-out mice there was an overproduction of Amyloid beta protein, tau hyper-phosphorylation, and behavioral abnormalities.
This study found that Cnga2 mice showed increased anxiety- and depressive-like behaviors than their wide type siblings.
Retinoic acid receptor (zeige RARA Proteine) and CNGA2 channel signaling are part of a regulatory feedback loop controlling axonal convergence and survival of olfactory sensory neurons.
CNGA2 channels contribute to ATP-induced non-capacitative calcium influx in vascular endothelial cells. It is likely that ATP acts through P2Y (zeige P2RY1 Proteine)(1)receptors and adenylyl cyclases to stimulate CNGA2.
Several odorants including putative pheromones can be detected and discriminated by CNGA2 knock-out mice behaviorally. These odors elicit responses in the olfactory epithelium, main olfactory bulb, and olfactory (piriform) cortex
Mice lacking functional CNGA2, which is required for odor-evoked MOE signaling, fail to mate or fight, suggesting a broad and essential role for the MOE in regulating these behaviors.
CNGA2 channels are not necessary for either the response of GnRH-1 (zeige GNRH1 Proteine) neurons to cAMP increases or the basal rhythmic activity of GnRH-1 (zeige GNRH1 Proteine) neurons.
The protein encoded by this gene represents the alpha subunit of a cyclic nucleotide-gated olfactory channel. The encoded protein contains a carboxy-terminal leucine zipper that mediates channel formation.
CNG channel alpha-2
, cyclic nucleotide gated channel 4
, cyclic nucleotide-gated cation channel 2
, cyclic nucleotide-gated channel alpha-2
, cyclic nucleotide-gated olfactory channel
, cyclic nucleotide-gated olfactory channel subunit OCNC1
, cyclic-nucleotide-gated cation channel 2
, cyclic-nucleotide-gated olfactory channel
, cAMP-gated channel
, cyclic nucleotide gated channel alpha 2