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The protein encoded by CNGA2 represents the alpha subunit of a cyclic nucleotide-gated olfactory channel. Zusätzlich bieten wir Ihnen Cyclic Nucleotide Gated Channel alpha 2 Antikörper (92) und viele weitere Produktgruppen zu diesem Protein an.
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The studies findings provides strong support for role of CNGA2 gene with pathogenicity of isolated congenital anosmia in humans. Together, these results indicate that mutations in key olfactory signaling pathway genes are responsible for human disease.
Identification of a novel X-linked stop mutation in CNGA2 (c.634C>T, p.R212*) in two brothers with isolated congenital anosmia.
The results showed that it is predominantly the charge of the E342 residue in the P-loop, rather than the pore helix dipoles, which controls the cation-anion selectivity of the CNGA2 channel.
CNGA2 channels play a key role in adenosine-induced endothelial Ca(2+) influx and vasorelaxation
Mediates epinephrine-induced endothelial calcium influx and subsequent vascular dilation.
In Cnga2 knock-out mice there was an overproduction of Amyloid beta protein, tau hyper-phosphorylation, and behavioral abnormalities.
This study found that Cnga2 mice showed increased anxiety- and depressive-like behaviors than their wide type siblings.
Retinoic acid receptor and CNGA2 channel signaling are part of a regulatory feedback loop controlling axonal convergence and survival of olfactory sensory neurons.
CNGA2 channels contribute to ATP-induced non-capacitative calcium influx in vascular endothelial cells. It is likely that ATP acts through P2Y(1)receptors and adenylyl cyclases to stimulate CNGA2.
important for odor discrimination and adaptation in behaving mice
Several odorants including putative pheromones can be detected and discriminated by CNGA2 knock-out mice behaviorally. These odors elicit responses in the olfactory epithelium, main olfactory bulb, and olfactory (piriform) cortex
Mice lacking functional CNGA2, which is required for odor-evoked MOE signaling, fail to mate or fight, suggesting a broad and essential role for the MOE in regulating these behaviors.
Function in the nose is unique to the main population of olfactory sensory neurons.
CNGA2 channels are not necessary for either the response of GnRH-1 neurons to cAMP increases or the basal rhythmic activity of GnRH-1 neurons.
The protein encoded by this gene represents the alpha subunit of a cyclic nucleotide-gated olfactory channel. The encoded protein contains a carboxy-terminal leucine zipper that mediates channel formation.
CNG channel alpha-2
, cyclic nucleotide gated channel 4
, cyclic nucleotide-gated cation channel 2
, cyclic nucleotide-gated channel alpha-2
, cyclic nucleotide-gated olfactory channel
, cyclic nucleotide-gated olfactory channel subunit OCNC1
, cyclic-nucleotide-gated cation channel 2
, cyclic-nucleotide-gated olfactory channel
, cAMP-gated channel
, cyclic nucleotide gated channel alpha 2