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The protein encoded by COG7 resides in the golgi, and constitutes one of the 8 subunits of the conserved oligomeric Golgi (COG) complex, which is required for normal golgi morphology and localization. Zusätzlich bieten wir Ihnen COG7 Antikörper (58) und und viele weitere Produktgruppen zu diesem Protein an.
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It has been demonstrated that the COG complex cooperates with Rab1 and GOLPH3 to regulate Golgi trafficking, and that overexpression of Rab1 can rescue the cytokinesis and locomotor defects associated with loss of Cog7.
Cog7 is an upstream component in a gio-Rab11 pathway controlling membrane addition during cytokinesis.
Targeted silencing of components of lobe B of the COG complex, namely COG5, COG6, COG7 and COG8, inhibited HIV-1 replication
Cog5-Cog7 crystal structure reveals interactions essential for the function of a multisubunit tethering complex.
COG5- and COG7 subunits play distinctive roles in controlling Golgi structure and function
Retrograde transport of multiple Golgi proteins to the ER in COG-7-deficient patient fibroblasts via brefeldin A-induced tubules was significantly slower than occurs in normal fibroblasts.
A homozygous, intronic splice site mutation (c.169+4A>C) of the COG7 gene was identified in 3 patients with Congenital Disorder of Glycosylation type IIe.
A new mutation in COG7 extends the spectrum of COG subunit deficiencies.
The protein encoded by this gene resides in the golgi, and constitutes one of the 8 subunits of the conserved oligomeric Golgi (COG) complex, which is required for normal golgi morphology and localization. Mutations in this gene are associated with the congenital disorder of glycosylation type IIe.
, component of oligomeric golgi complex 7
, conserved oligomeric Golgi complex subunit 7
, conserved oligomeric Golgi complex subunit 7-like
, COG complex subunit 7