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The protein encoded by COG7 resides in the golgi, and constitutes one of the 8 subunits of the conserved oligomeric Golgi (COG) complex, which is required for normal golgi morphology and localization. Zusätzlich bieten wir Ihnen COG7 Antikörper (57) und und viele weitere Produktgruppen zu diesem Protein an.
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It has been demonstrated that the COG (zeige TG Proteine) complex cooperates with Rab1 (zeige RAB1A Proteine) and GOLPH3 (zeige GOLPH3 Proteine) to regulate Golgi trafficking, and that overexpression of Rab1 (zeige RAB1A Proteine) can rescue the cytokinesis and locomotor defects associated with loss of Cog7.
Cog7 is an upstream component in a gio-Rab11 pathway controlling membrane addition during cytokinesis.
Targeted silencing of components of lobe B of the COG (zeige TG Proteine) complex, namely COG5 (zeige COG5 Proteine), COG6 (zeige COG6 Proteine), COG7 and COG8 (zeige COG8 Proteine), inhibited HIV-1 replication
Cog5 (zeige COG5 Proteine)-Cog7 crystal structure reveals interactions essential for the function of a multisubunit tethering complex.
COG5 (zeige COG5 Proteine)- and COG7 subunits play distinctive roles in controlling Golgi structure and function
Retrograde transport of multiple Golgi proteins to the ER in COG-7-deficient patient fibroblasts via brefeldin A-induced tubules was significantly slower than occurs in normal fibroblasts.
A homozygous, intronic splice site mutation (c.169+4A>C) of the COG7 gene was identified in 3 patients with Congenital Disorder of Glycosylation type IIe.
A new mutation in COG7 extends the spectrum of COG (zeige TG Proteine) subunit deficiencies.
The protein encoded by this gene resides in the golgi, and constitutes one of the 8 subunits of the conserved oligomeric Golgi (COG) complex, which is required for normal golgi morphology and localization. Mutations in this gene are associated with the congenital disorder of glycosylation type IIe.
, component of oligomeric golgi complex 7
, conserved oligomeric Golgi complex subunit 7
, conserved oligomeric Golgi complex subunit 7-like
, COG complex subunit 7