Collagen and Calcium Binding EGF Domains 1 Proteine (CCBE1)

CCBE1 encodes a protein containing an emilin domain and two collagen stretches. Zusätzlich bieten wir Ihnen CCBE1 Antikörper (47) und CCBE1 Kits (5) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
CCBE1 147372 Q6UXH8
CCBE1 320924 Q3MI99
Ratte CCBE1 CCBE1 361341  
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Showing 4 out of 4 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
Details
Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage
$338.33
Details
Hefe Zebrafisch His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,041.50
Details

CCBE1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
,
Mouse (Murine)

Weitere Proteine zu Collagen and Calcium Binding EGF Domains 1 (CCBE1) Interaktionspartnern

Human Collagen and Calcium Binding EGF Domains 1 (CCBE1) Interaktionspartner

  1. the present results demonstrated that CCBE1 expression was downregulated in lung cancer, particularly in the presence of LNM.

  2. these data indicated that CCBE1 may be served as a new predictor of prognosis in post-operative gastrointestinal stromal tumor patients and may play an important role in stimulating tumor progression

  3. We identify CCBE1 as a direct target of miR (zeige MLXIP Proteine)-330-3p, and show that knockdown of CCBE1 results in a greater invasive capacity. Accordingly, in breast cancer patients CCBE1 is frequently downregulated, and its loss is associated with reduced distant relapse-free and overall survival.

  4. Collagen domains of CCBE1 are crucial for the activation of VEGFC (zeige VEGFC Proteine) in vitro and in vivo. The EGF (zeige EGF Proteine) domains of CCBE1 are dispensable for regulation of VEGFC (zeige VEGFC Proteine) processing in vitro, however, they are necessary for full lymphangiogenic activity of CCBE1 in vivo.

  5. CCBE1 enhances lymphangiogenesis via A disintegrin and metalloprotease with thrombospondin motifs-3-mediated vascular endothelial growth factor-C (zeige VEGFC Proteine) activation.

  6. Both siblings harbored a homozygous mutation in CCBE1.

  7. The study has shown that CCBE1 mutations are not a major contributor to non-immune hydrops fetalis.

  8. Human CCBE1 strongly enhances vascular endothelial growth factor-C-mediated lymphangiogenesis in a corneal micropocket assay

  9. Loss of CCBE1 expression may promote ovarian carcinogenesis by enhancing migration & cell survival. CCBE1 is a new candidate tumour suppressor in ovarian cancer.

  10. Homozygous cysteine to serine change and SNPS in CCBE1 were identified patients.

Mouse (Murine) Collagen and Calcium Binding EGF Domains 1 (CCBE1) Interaktionspartner

  1. Collagen domains of CCBE1 are crucial for the activation of VEGFC (zeige VEGFC Proteine) in vitro and in vivo. The EGF (zeige EGF Proteine) domains of CCBE1 are dispensable for regulation of VEGFC (zeige VEGFC Proteine) processing in vitro, however, they are necessary for full lymphangiogenic activity of CCBE1 in vivo.

  2. CCBE1 enhances lymphangiogenesis via A disintegrin and metalloprotease (zeige ADAMTS7 Proteine) with thrombospondin motifs-3-mediated vascular endothelial growth factor-C (zeige VEGFC Proteine) activation.

  3. Ccbe1 has an essential role in lymphangiogenesis [review]

  4. The secreted lymphangiogenic protein CCBE1 is essential for fetal but not postnatal erythropoiesis.

  5. Ccbe1 expression marks the cardiac and lymphatic progenitor lineages during early stages of mouse development

  6. Phenotypic analysis of murine Ccbe1 mutant embryos show a complete lack of definitive lymphatic structures, even though lymphatic endothelial cells are specified within the cardinal (zeige CARD8 Proteine) vein

Zebrafish Collagen and Calcium Binding EGF Domains 1 (CCBE1) Interaktionspartner

  1. Collagen domains of CCBE1 are crucial for the activation of VEGFC (zeige VEGFC Proteine) in vitro and in vivo. The EGF (zeige EGF Proteine) domains of CCBE1 are dispensable for regulation of VEGFC (zeige VEGFC Proteine) processing in vitro, however, they are necessary for full lymphangiogenic activity of CCBE1 in vivo.

  2. In the embryo, phenotypes driven by increased Vegfc (zeige VEGFC Proteine) are suppressed in the absence of Ccbe1, and Vegfc (zeige VEGFC Proteine)-driven sprouting is enhanced by local Ccbe1 overexpression. Moreover, Vegfc (zeige VEGFC Proteine)- and Vegfr3 (zeige FLT4 Proteine)-dependent Erk (zeige MAPK1 Proteine) signaling is impaired in the absence of Ccbe1.

CCBE1 Protein Überblick

Protein Überblick

This gene is thought to function in extracellular matrix remodeling and migration. It is predominantly expressed in the ovary, but down regulated in ovarian cancer cell lines and primary carcinomas, suggesting its role as a tumour suppressor. Mutations in this gene have been associated with Hennekam lymphangiectasia-lymphedema syndrome, a generalized lymphatic dysplasia in humans.

Genbezeichner und Symbole assoziert mit CCBE1

  • collagen and calcium binding EGF domains 1 (CCBE1)
  • collagen and calcium binding EGF domains 1 (Ccbe1)
  • collagen and calcium binding EGF domains 1 (ccbe1)
  • 4933426F18Rik Protein
  • 9430093N24Rik Protein
  • fof Protein
  • mKIAA1983 Protein
  • RGD1307670 Protein

Bezeichner auf Proteinebene für CCBE1

collagen and calcium-binding EGF domain-containing protein 1 , full of fluid protein homolog , collagen and calcium binding EGF domains 1 , full of fluid protein , LOW QUALITY PROTEIN: collagen and calcium-binding EGF domain-containing protein 1

GENE ID SPEZIES
147372 Homo sapiens
320924 Mus musculus
361341 Rattus norvegicus
455449 Pan troglodytes
534569 Bos taurus
555629 Danio rerio
610092 Canis lupus familiaris
702222 Macaca mulatta
770043 Gallus gallus
100593092 Nomascus leucogenys
100727972 Cavia porcellus
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